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Total 91 results found since Jan 2013.

Risk of Ischemic and Hemorrhagic Strokes in Occult and Manifest Cancers Clinical Sciences
Conclusions—Cancer, occult and manifest, is associated with increased risks for stroke. The increased risk is linked mainly to cancers related to smoking.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Klaus Kaae Andersen, Tom Skyhoȷ Olsen Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort
Conclusion In this prospective cohort of community-dwelling adults we observed that cancer survivors had more than a 2.5-fold increased risk of sepsis. Public health efforts should attempt to mitigate sepsis risk by awareness and appropriate treatment (e.g., antibiotic administration) to cancer survivors with suspected infection regardless of the number of years since cancer remission.
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Cystatin C takes part in melanoma-microglia cross-talk:  possible implications for brain metastasis
AbstractThe development of melanoma brain metastasis is largely dependent on mutual interactions between the melanoma cells and cells in the brain microenvironment. Here, we report that the extracellular cysteine protease inhibitor cystatin C (CysC) is involved in these interactions. Microglia-derived factors upregulated CysC secretion by melanoma. Similarly, melanoma-derived factors upregulated CysC secretion by microglia. Whereas CysC enhanced melanoma cell migration through a layer of brain endothelial cells, it inhibited the migration of microglia cells toward melanoma cells. CysC was also found to promote the formatio...
Source: Clinical and Experimental Metastasis - May 2, 2018 Category: Cancer & Oncology Source Type: research

Stroke-like symptoms and leptomeningeal FLAIR hyperintensity in a neurofibromatosis type 1 patient with primary leptomeningeal melanoma
Source: Acta Neurologica Belgica - April 23, 2018 Category: Neurology Source Type: research

Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy
CONCLUSION. Our findings uncover a major cause of sporadic VMs of different clinical types and thereby offer the potential of personalized medical treatment by repurposing existing licensed cancer therapies. FUNDING. This work was funded or supported by grants from the AVM Butterfly Charity, the Wellcome Trust (UK), the Medical Research Council (UK), the UK National Institute for Health Research, the L’Oreal-Melanoma Research Alliance, the European Research Council, and the National Human Genome Research Institute (US).
Source: Journal of Clinical Investigation - March 12, 2018 Category: Biomedical Science Authors: Lara Al-Olabi, Satyamaanasa Polubothu, Katherine Dowsett, Katrina A. Andrews, Paulina Stadnik, Agnel P. Joseph, Rachel Knox, Alan Pittman, Graeme Clark, William Baird, Neil Bulstrode, Mary Glover, Kristiana Gordon, Darren Hargrave, Susan M. Huson, Thomas Source Type: research

UCLA helps many to live long and prosper
In Westwood, more than 100 faculty experts from 25 departments have embarked on anall-encompassing push to cut the health and economic impacts of depression in half by the year 2050. The mammoth undertaking will rely on platforms developed by the new Institute for Precision Health, which will harness the power of big data and genomics to move toward individually tailored treatments and health-promotion strategies.On the same 419 acres of land, researchers across the spectrum, from the laboratory bench to the patient bedside, are ushering in a potentially game-changing approach to turning the body ’s immune defenses again...
Source: UCLA Newsroom: Health Sciences - November 9, 2017 Category: Universities & Medical Training Source Type: news

In Defense of Progesterone: A Review of the Literature.
Conclusions • Physicians should have no hesitation prescribing natural progesterone. The evidence is clear that progesterone does not cause breast cancer. Indeed, progesterone is protective and preventative of breast cancer. PMID: 29055286 [PubMed - as supplied by publisher]
Source: Alternative Therapies in Health and Medicine - October 21, 2017 Category: Complementary Medicine Authors: Lieberman A, Curtis L Tags: Altern Ther Health Med Source Type: research

Juvenile melanomas: Western Australian Melanoma Advisory Service experience.
CONCLUSIONS: Juvenile melanoma remains a rarity in Western Australia despite a very high incidence of adult melanoma. Unlike in adults, no definitive risk factors have been established. A significant proportion of this cohort had a pre-existing naevus and while most melanomas occurred in sun-exposed areas in light-skinned individuals the association between sunburn and melanoma was not strong. PMID: 28809039 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - August 15, 2017 Category: Dermatology Authors: Xu JX, Koek S, Lee S, Hanikeri M, Lee M, Beer T, Saunders C Tags: Australas J Dermatol Source Type: research

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence
Conclusions: Population level of iAs% and DMA%, but not MMA%, were associated with arsenic exposure levels. Overall, study findings suggest that higher MMA% was associated with an increased risk of cancer and cardiovascular disease, while lower MMA% was associated with an increased risk of diabetes and metabolic syndrome. Additional population-based studies and experimental studies are needed to further evaluate and understand the role of arsenic exposure in arsenic metabolism and the role of arsenic metabolism in disease development. https://doi.org/10.1289/EHP577 Received: 01 June 2016 Revised: 26 February 2017 Acce...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

High-resolution magnetic resonance imaging of intracranial aneurysms treated by flow diversion
Conclusion HRMRI is a useful tool to evaluate aneurysm treatment by flow diversion and may represent an alternative to repeat digital subtraction angiography.
Source: Interdisciplinary Neurosurgery - July 13, 2017 Category: Neurosurgery Source Type: research

Juvenile melanomas: Western Australian Melanoma Advisory Service experience
ConclusionsJuvenile melanoma remains a rarity in Western Australia despite a very high incidence of adult melanoma. Unlike in adults, no definitive risk factors have been established. A significant proportion of this cohort had a pre‐existing naevus and while most melanomas occurred in sun‐exposed areas in light‐skinned individuals the association between sunburn and melanoma was not strong.
Source: Australasian Journal of Dermatology - May 1, 2017 Category: Dermatology Authors: Jie Xin Xu, Sharnice Koek, Samantha Lee, Mark Hanikeri, Mark Lee, Trevor Beer, Christobel Saunders Tags: Original Research Source Type: research

Neurologic manifestations of geriatric patients with cancer (P6.188)
Conclusions:Neurologic manifestations are reported in about 40% of patients with cancer, approximately half of living patients with cancer are over 65 years of age, this increase merits the medical and related personnel to be prepared and recognize, diagnose and treat this highly morbid conditions. Neurologic manifestations and diagnoses in patients with cancer are different in the elderly and should be treated individually; the present work offers information regarding clinical symptoms and neurologic diagnoses in this population.Disclosure: Dr. Cacho Diaz has nothing to disclose. Dr. Lorenzana-Mendoza has nothing to disc...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Diaz, B. C., Lorenzana-Mendoza, N., Soto, G. R., Gomez, A. H. Tags: Neurologic Complications of Cancer Source Type: research

Is red hair gene linked to increased risk of Parkinson's?
Conclusion This study looked at the role the red hair gene MC1R plays in the brains of mice. The findings suggest the gene has a part to play in keeping certain nerve cells in the brain alive. The cells in question are those that die off in Parkinson's disease and cause the condition's characteristic movement problems. These findings in mice are likely to need further investigation in human cells and tissue in lab studies. Exactly what causes brain cells to die, causing Parkinson's disease, is unknown. As with many conditions, it's thought both genetic and environmental factors could play a role. Research like this helps...
Source: NHS News Feed - March 6, 2017 Category: Consumer Health News Tags: Cancer Genetics/stem cells Source Type: news

7 Foot Problems That Can Be Serious
If you want to know the state of your health, try looking down. “There’s no question it’s extremely important that people pay attention to their feet,” says Terry Philbin, D.O., spokesperson for the American Academy of Orthopedic Surgeons (AAOS) and a foot and ankle specialist at the Orthopedic Foot and Ankle Center in Westerville, Ohio. The condition of your feet can give you clues to a host of medical issues, such as diabetes, arthritis, and even heart disease. Read on to find out what to look for and what it may mean. 1. Pain “There’s no pain that should be ignored,” says Jane ...
Source: Healthy Living - The Huffington Post - November 12, 2016 Category: Consumer Health News Source Type: news

3 Major Health Problems That Disproportionately Affect Vets
Veterans are more likely to report very good or excellent health than their civilian counterparts, so they may not realize that they’re also at greater risk than civilians for some long-term health problems. Of course, many veterans have acute physical health problems, like wounds and amputations, and trauma-based mental health issues like depression and PTSD. Indeed, mental health issues affect 30 percent of Vietnam veterans, 20 percent of Iraqi veterans and about 10 percent of Gulf War and Afghanistan veterans. Less known are some of the ordinary, chronic conditions that disproportionately affect ser...
Source: Healthy Living - The Huffington Post - November 11, 2016 Category: Consumer Health News Source Type: news