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Cancer: Melanoma
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Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver.
Abstract
High circulating cholesterol is associated with hypercholesterolemia, atherosclerosis, and stroke. However, the relation between cholesterol and tumorigenesis/metastasis is controversial. The proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates low-density lipoprotein cholesterol homeostasis by targeting the low-density lipoprotein receptor (LDLR) for degradation. PCSK9 is mostly expressed in liver, which is one of the most common sites for metastatic disease. To reveal the function of PCSK9 and also evaluate the impact of cholesterol in liver metastasis development, B16F1 melanoma cells were i...
Source: Neoplasia - December 1, 2012 Category: Cancer & Oncology Authors: Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, Prat A Tags: Neoplasia Source Type: research
