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Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients
CONCLUSIONS AND RELEVANCE: In an exploratory analysis of patients who received red blood cell transfusions, patients who underwent transfusion with red blood cells from donors who later developed multiple spontaneous ICHs were at significantly increased risk of spontaneous ICH themselves. This may suggest a transfusion-transmissible agent associated with some types of spontaneous ICH, although the findings may be susceptible to selection bias and residual confounding, and further research is needed to investigate if transfusion transmission of cerebral amyloid angiopathy might explain this association.PMID:37698562 | DOI:1...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Jingcheng Zhao Klaus Rostgaard Elsa Lauwers Torsten Dahl én Sisse Rye Ostrowski Christian Erikstrup Ole Birger Pedersen Bart de Strooper Robin Lemmens Henrik Hjalgrim Gustaf Edgren Source Type: research

High consumption of dairy products and risk of major adverse coronary events and stroke in a Swedish population
Br J Nutr. 2023 Sep 6:1-28. doi: 10.1017/S0007114523001939. Online ahead of print.ABSTRACTThe association between consumption of dairy products and risk of cardiovascular diseases (CVD) has been inconsistent. There is a lack of studies in populations with high intakes of dairy products. We aimed to examine the association between intake of dairy products and risk of incident major adverse coronary events and stroke in the Swedish Malmö Diet and Cancer cohort study. We included 26,190 participants without prevalent CVD or diabetes. Dietary habits were obtained from a modified diet history and endpoint data were extracted f...
Source: The British Journal of Nutrition - September 6, 2023 Category: Nutrition Authors: Justine Dukuzimana Suzanne Janzi Caroline Habberstad Shunming Zhang Yan Born é Emily Sonestedt Source Type: research

News at a glance: A win for obesity drugs, NIH unionization roadblocks, and Mexican fireflies under threat
CONSERVATION Researchers raise alarm over threat to Mexican fireflies Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species Photinus palaciosi . Endemic to Mexico’s Tlaxcala forests, P. palaciosi is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: ScienceNOW - August 10, 2023 Category: Science Source Type: news

News at a glance: A win for obesity drugs, a new infectious disease institute head, and Mexican fireflies under threat
CONSERVATION Researchers raise alarm over threat to Mexican fireflies Scientists from the International Union for Conservation of Nature (IUCN) last week delivered a letter to the Mexican government requesting it regulate tourism centered on the threatened firefly species Photinus palaciosi . Endemic to Mexico’s Tlaxcala forests, P. palaciosi is one of the few species that glow in synchrony, offering an annual spectacle that attracts thousands of visitors during summer mating season. The letter describes how littering, artificial light, and noise interfere with the insects’ courtship and eg...
Source: Science of Aging Knowledge Environment - August 10, 2023 Category: Geriatrics Source Type: research

Proton Pump Inhibitor and Clopidogrel Use After Percutaneous Coronary Intervention and Risk of Major Cardiovascular Events
ConclusionsIn patients who receive clopidogrel after PCI, concomitant use of PPI seems to increase the risk of major cardiovascular events.
Source: Cardiovascular Drugs and Therapy - November 11, 2022 Category: Cardiology Source Type: research

Mortality and Morbidity Effects of Long-Term Exposure to Low-Level PM < sub > 2.5 < /sub > , BC, NO < sub > 2 < /sub > , and O < sub > 3 < /sub > : An Analysis of European Cohorts in the ELAPSE Project
CONCLUSIONS: Long-term exposure to PM2.5, NO2, and BC was positively associated with natural-cause and cause-specific mortality in the pooled cohort and the administrative cohorts. Associations were found well below current limit values and guidelines for PM2.5 and NO2. Associations tended to be supralinear, with steeper slopes at low exposures with no indication of a threshold. Two-pollutant models documented the importance of characterizing the ambient mixture with both NO2 and PM2.5. We mostly found negative associations with O3. In two-pollutant models with NO2, the negative associations with O3 were attenuated to esse...
Source: Cancer Control - September 15, 2022 Category: Cancer & Oncology Authors: Brunekreef Bert Strak Maciej Chen Jie J Andersen Zorana Atkinson Richard Bauwelinck Mariska Bellander Tom Boutron Marie-Christine Brandt J ørgen Carey Iain Cesaroni Giulia Forastiere Francesco Fecht Daniela Gulliver John Hertel Ole Hoffmann Barbara de Ho Source Type: research

Anemia is associated with increased risk of non-vertebral osteoporotic fractures in elderly men: the MrOS Sweden cohort
ConclusionsAnemia is associated with an increased risk for any fracture and non-vertebral osteoporotic fracture in elderly men with a long follow-up time. The cause is probably multifactorial and our results support that anemia can be used as a predictor for future fracture.
Source: Archives of Orthopaedic and Trauma Surgery - June 23, 2022 Category: Orthopaedics Source Type: research

Incident cardiovascular disease and long-term exposure to source-specific air pollutants in a Swedish cohort
CONCLUSION: In an area with low to moderate air pollution exposure, we observed significant associations of long-term residential NOx with increased risk of incident CHF and fatal MI, but not with coronary events and stroke.PMID:35074356 | DOI:10.1016/j.envres.2022.112698
Source: Environmental Research - January 25, 2022 Category: Environmental Health Authors: Hanne Krage Carlsen Eva M Andersson Peter Moln ár Anna Oudin Yiyi Xu Janine Wichmann M årten Spanne Emilie Stroh Gunnar Engstr öm Leo Stockfelt Source Type: research

A third of dying patients do not have end-of-life discussions with a physician: A nationwide registry study
Palliat Support Care. 2021 Jun 23:1-6. doi: 10.1017/S1478951521000973. Online ahead of print.ABSTRACTOBJECTIVE: The aim of the study was to explore the proportion of adult patients and next-of-kin who had end-of-life (EOL) discussions and associated factors.METHOD: A retrospective nationwide registry study was reported with data from the Swedish Register of Palliative Care. All patients in Sweden in hospitals, nursing homes, own homes, community, and palliative care units during 2015-2017 and their next-of-kin were included. Data were reported to the register by healthcare staff, based on diseased patients' records regardi...
Source: Palliative and Supportive Care - June 23, 2021 Category: Palliative Care Authors: Christina Melin-Johansson Josefin Sveen Malin L övgren Camilla Udo Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Diet and Lifestyle as Risk Factors for Carotid Artery Disease: A Prospective Cohort Study
Conclusions: In conclusion, the present study found a trend toward a protective effect of higher intake of vegetables and fruit against incident CAD. More prospective studies investigating the association between diet and CAD and stroke are needed in order to give firm recommendations.Cerebrovasc Dis
Source: Cerebrovascular Diseases - October 19, 2020 Category: Neurology Source Type: research

Risk factors for severe bleeding events during warfarin treatment: the influence of sex, age, comorbidity and co-medication
ConclusionMost of the well-established risk factors were found to be significantly associated with bleeding events in our study. We additionally found that women had a lower incidence of bleeding. Potential biases are selection effects, residual confounding and unmeasured frailty.
Source: European Journal of Clinical Pharmacology - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Risk of Ischemic Stroke and Major Bleeding in Patients With Atrial Fibrillation and Cancer
Background: Atrial fibrillation (AF) is an important risk factor for ischemic stroke. Cancer may increase the risk both of ischemic stroke and of bleeding. Less is known about risk of ischemic stroke and bleeding among cancer patients with AF, complicating the prevention of ischemic stroke in these patients. Methods: Register based cohort study comprising all Swedish patients hospitalized with a primary diagnosis of AF from July 1, 2005 until December 31, 2014. Patients with cancer diagnosis were compared to the rest of the cohort.
Source: Journal of Stroke and Cerebrovascular Diseases - December 26, 2019 Category: Neurology Authors: Sara Aspberg, Liyang Yu, Bruna Gigante, Karin E Smedby, Daniel E Singer Source Type: research

Self-rated health and venous thromboembolism among middle-aged women: a population-based cohort study
This study supports previous results with varico se veins and waist circumference as strong predictors of VTE. Poor self-rated health does not seem to be a valid predictor of VTE. Among lifestyle-related parameters, smoking was significantly associated with risk of VTE. We could also confirm the effect of the other already known risk factors.
Source: Journal of Thrombosis and Thrombolysis - November 18, 2019 Category: Hematology Source Type: research

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