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Total 838 results found since Jan 2013.

Vitamin C and scar strength: analysis of a historical trial and implications for collagen-related pathologies
Am J Clin Nutr. 2021 Aug 16:nqab262. doi: 10.1093/ajcn/nqab262. Online ahead of print.ABSTRACTA double-blind controlled trial initiated in 1944 has led to the common narrative that a 10-mg daily vitamin C intake is adequate to prevent and treat impaired wound healing, and by inference, other collagen-related diseases such as heart disease or stroke. The WHO relies on this narrative to set the recommended nutrient intake for vitamin C. This narrative, however, is based on what is known as the eyeball method of data assessment. The 1944 trial published individual participant data on scar strength providing an opportunity to ...
Source: Am J Clin Nutr - August 16, 2021 Category: Nutrition Authors: Philippe P Hujoel Margaux L A Hujoel Source Type: research

28464 Hidradenitis suppurativa and association with stroke: Systematic review and meta-analysis
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by painful nodules, abscesses, sinus tract formation, and scarring. HS has a number of associations with systemic disorders, including cardiovascular disease and metabolic syndrome. However, the relationship between HS and strokes is not well established. To assess this potential association, a systematic review and meta-analysis was performed.
Source: Journal of the American Academy of Dermatology - August 8, 2021 Category: Dermatology Authors: Kevin Phan, William Ng, Belinda Lai, Amit Garg, Saxon D. Smith Source Type: research

28675 A case of systemic amyloidosis diagnosed by dermatologic consult
A 49-year-old male with PMH of hypertension and diabetes was admitted to the neurology ICU following thrombolytic therapy for left MCA occlusive thrombus. Dermatology was consulted for desquamation of the lower lip, lateral tongue, and bruising of the eyelid and cheeks. Patient originally presented to outside hospital with bilateral lower extremity swelling and shortness of breath. BNP and troponins were elevated, and ACS protocol was initiated. He had stroke-like symptoms while at the outside facility and CT showed MCA occlusive thrombus.
Source: Journal of the American Academy of Dermatology - August 8, 2021 Category: Dermatology Authors: Alison Huber, Dr. Emily Smith Source Type: research

Ras-like Gem GTPase induced by Npas4 promotes activity-dependent neuronal tolerance for ischemic stroke Neuroscience
Ischemic stroke, which results in loss of neurological function, initiates a complex cascade of pathological events in the brain, largely driven by excitotoxic Ca2+ influx in neurons. This leads to cortical spreading depolarization, which induces expression of genes involved in both neuronal death and survival; yet, the functions of these...
Source: Proceedings of the National Academy of Sciences - August 4, 2021 Category: Science Authors: Hiroo Takahashi, Ryo Asahina, Masayuki Fujioka, Takeshi K. Matsui, Shigeki Kato, Eiichiro Mori, Hiroyuki Hioki, Tohru Yamamoto, Kazuto Kobayashi, Akio Tsuboi Tags: Neuroscience Biological Sciences Source Type: research

The dream of a good night's sleep for our dermatology patients
Are you getting adequate sleep? Chances are that you are not and the repercussions could be profound. Sleep deprivation has been associated with insulin resistance, diabetes mellitus, obesity, hypertension, obstructive sleep apnea, anxiety and depression, and an increased risk of myocardial infarction and stroke. Quality of life (QoL) may suffer by poor job performance, an increased risk of accidents, and family stress.1
Source: Journal of the American Academy of Dermatology - August 2, 2021 Category: Dermatology Authors: Warren R. Heymann Tags: A clinician's perspective Source Type: research

Predisposing factors and management of hemodynamic depression following carotid artery stenting
Pachipala Sudheer, Ayush Agarwal, Venugopalan Y Vishnu, MV Padma SrivastavaAnnals of Indian Academy of Neurology 2021 24(3):315-318 Carotid artery stenting (CAS) involves dilatation of carotid bulb which can trigger a series of neuronal responses resulting in hemodynamic depression that might influence the outcome of the procedure. This is a frequent but underdiagnosed complication of CAS. Although it is mild, transient and self-limiting in majority of cases, it can result in significant morbidity and mortality if persistent. Neurologists should be aware of the predisposing factors and management of this common complicati...
Source: Annals of Indian Academy of Neurology - July 17, 2021 Category: Neurology Authors: Pachipala Sudheer Ayush Agarwal Venugopalan Y Vishnu MV Padma Srivastava Source Type: research

& #8216;More than just skin in the game & #8217;. DADA2 autoinflammatory syndrome and stroke in the young
Ashin Varghese, Joe Thomas, Boby Varkey MaramattomAnnals of Indian Academy of Neurology 2021 24(3):410-412 A 21-year-old man had a long-standing history of leg ulcers and hyperpigmention over the feet. Over a span of 8 months, he had an acute ischemic stroke followed by a basal ganglia hemorrhage. He was finally diagnosed with DADA2 syndrome after genetic sequencing. The implications of this new syndrome and its links to stroke in the young are presented in this article.
Source: Annals of Indian Academy of Neurology - July 17, 2021 Category: Neurology Authors: Ashin Varghese Joe Thomas Boby Varkey Maramattom Source Type: research

Haptoglobin gene polymorphism and ischemic stroke: A case control study
Divyani Garg, Saraswathy N Kallur, Barun Kumar, Rajinder K DhamijaAnnals of Indian Academy of Neurology 2021 24(3):447-448
Source: Annals of Indian Academy of Neurology - July 17, 2021 Category: Neurology Authors: Divyani Garg Saraswathy N Kallur Barun Kumar Rajinder K Dhamija Source Type: research

Circulating granulocyte colony-stimulating factor and functional outcome after ischemic stroke: an observational study
Discussion: Early post-stroke S-GCSF is increased in severe IS and associated with 3-month poor functional outcomes. The change in S-GCSF and the 3-month S-GCSF appear to be less-important, and S-GCSF likely reflects inflammation in large infarctions.PMID:34253146 | DOI:10.1080/01616412.2021.1948766
Source: Neurological Research - July 13, 2021 Category: Neurology Authors: Alexander Wall Olof Anger Katarina Jood Christian Blomstrand Ulf Andreasson Kaj Blennow Henrik Zetterberg J örgen Isgaard Christina Jern N David Åberg Johan Svensson Source Type: research

Heat shock proteins: a history of study in Russia
Cell Stress Chaperones. 2021 Jun 28. doi: 10.1007/s12192-021-01219-z. Online ahead of print.ABSTRACTThis review describes a brief history of the discovery and studies in Russia and associated countries of the main stress protein (Hsp70) that plays important roles both in the normal function of the cell and body as well as under various stressful stimuli. Research on this protein at the Institute of Molecular Biology (Moscow) began with the elucidation of its adaptive functions at the cellular level and at the level of the whole organism. These studies examined the function of Hsp70 under normal and extreme conditions using...
Source: Cell Stress and Chaperones - June 29, 2021 Category: Cytology Authors: Mikhail Borisovich Evgen'ev Source Type: research

Serial sarcomere number is substantially decreased within the paretic biceps brachii in individuals with chronic hemiparetic stroke Applied Biological Sciences
A muscle’s structure, or architecture, is indicative of its function and is plastic; changes in input to or use of the muscle alter its architecture. Stroke-induced neural deficits substantially alter both input to and usage of individual muscles. We combined in vivo imaging methods (second-harmonic generation microendoscopy, extended field-of-view ultrasound,...
Source: Proceedings of the National Academy of Sciences - June 25, 2021 Category: Science Authors: Amy N. Adkins, Julius P. A. Dewald, Lindsay P. Garmirian, Christa M. Nelson, Wendy M. Murray Tags: Applied Biological Sciences Source Type: research

Age and Life-Sustaining Treatment Preferences in Parkinson Disease
Conclusions Advancing age in PD may correlate with paradoxically more aggressive goals as it relates to life-sustaining treatment preferences including cardiopulmonary resuscitation. This may reflect a response to heightened concern among older adults with PD about the potential for compromised autonomy in the setting of aging.
Source: Neurology Clinical Practice - June 7, 2021 Category: Neurology Authors: Jackowiak, E., Szpara, A., Kotagal, V. Tags: Parkinson's disease/Parkinsonism, Palliative care Research Source Type: research

A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function Biophysics and Computational Biology
Changes in the molecular properties of cardiac myosin strongly affect the interactions of myosin with actin that result in cardiac contraction and relaxation. However, it remains unclear how myosin molecules work together in cardiac myofilaments and which properties of the individual myosin molecules impact force production to drive cardiac contractility....
Source: Proceedings of the National Academy of Sciences - June 4, 2021 Category: Science Authors: Yongtae Hwang, Takumi Washio, Toshiaki Hisada, Hideo Higuchi, Motoshi Kaya Tags: Biophysics and Computational Biology Biological Sciences Source Type: research