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Total 838 results found since Jan 2013.

Pure-sensory stroke in pons presented isolated perioral sensory symptoms
Young Seo Kim, Hyun Young ParkAnnals of Indian Academy of Neurology 2021 24(1):84-84
Source: Annals of Indian Academy of Neurology - February 16, 2021 Category: Neurology Authors: Young Seo Kim Hyun Young Park Source Type: research

Bee sting-induced acute ischemic stroke: A new manifestation of kounis syndrome ?
Nicholas G Kounis, Ioanna Koniari, Panagiotis Plotas, Andreas Argyriou, George D Soufras, Grigorios Tsigkas, Periklis Davlouros, George HahalisAnnals of Indian Academy of Neurology 2021 24(1):118-120
Source: Annals of Indian Academy of Neurology - February 16, 2021 Category: Neurology Authors: Nicholas G Kounis Ioanna Koniari Panagiotis Plotas Andreas Argyriou George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis Source Type: research

Brain metastasis in a patient with multiple malignancies
Brain metastases originate from other primary cancers within the body, most commonly lung, breast, and melanoma. Because patients with brain metastasis, stroke, or intracranial hemorrhage may present with similar acute neurologic symptoms, clinicians must have a high suspicion for brain metastasis and perform an immediate workup to rule out life-threatening conditions. This case report focuses on the clinical symptoms, diagnostics, and treatment options for brain metastasis in a patient with multiple malignancies.
Source: Journal of the American Academy of Physician Assistants - February 1, 2021 Category: Primary Care Tags: Case Report Source Type: research

Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration Neuroscience
Identifying molecular mediators of neural circuit development and/or function that contribute to circuit dysfunction when aberrantly reengaged in neurological disorders is of high importance. The role of the TWEAK/Fn14 pathway, which was recently reported to be a microglial/neuronal axis mediating synaptic refinement in experience-dependent visual development, has not been explored...
Source: Proceedings of the National Academy of Sciences - February 1, 2021 Category: Science Authors: David Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong–Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihaly Haȷos, Linda C. Burkly Tags: Neuroscience Biological Sciences Source Type: research

Targeted Cancer Therapies.
Abstract Targeted cancer therapies involve chemotherapeutic agents that attack, directly or indirectly, a specific genetic biomarker found in a given cancer. Targeted oncology includes monoclonal antibodies, small molecule inhibitors, antibody-drug conjugates, and immunotherapy. For example, the monoclonal antibodies trastuzumab and pertuzumab target human epidermal growth factor receptor 2 (HER2) and are used when treating HER2-positive breast cancer. Although targeted oncology has improved survival by years for some incurable cancers such as metastatic breast and lung cancer, as few as 8% of patients with advanc...
Source: American Family Physician - January 30, 2021 Category: Primary Care Authors: Smith CEP, Prasad V Tags: Am Fam Physician Source Type: research

Patent foramen ovale closure in the management of cryptogenic stroke: a review of current literature and guideline statements.
CONCLUSION: PFO closure can be considered for the prevention of recurrent cryptogenic stroke in patients aged ≤60 years after a thorough evaluation and discussion about benefits and potential risks (including but not limited to atrial fibrillation) of the procedure. Accumulating evidence supports prognostic, quality of life, and economic benefit from percutaneous PFO closure with newer generation closure devices in the right subset of patients. PMID: 33460329 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - January 20, 2021 Category: Research Tags: Curr Med Res Opin Source Type: research

Management of Patients With a Patent Foramen Ovale With History of Stroke or TIA
This Clinical Guidelines Synopsis summarizes the American Academy of Neurology ’s practice advisory update on management of patients with a patent foramen ovale who have a history of stroke or transient ischemic attack.
Source: JAMA - January 5, 2021 Category: General Medicine Source Type: research

Poststroke acute dysexecutive syndrome, a disorder resulting from minor stroke due to disruption of network dynamics Neuroscience
Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be responsible. Nine patients with recent minor strokes and...
Source: Proceedings of the National Academy of Sciences - December 29, 2020 Category: Science Authors: Elisabeth B. Marsh, Christian Brodbeck, Rafael H. Llinas, Dania Mallick, Joshua P. Kulasingham, Jonathan Z. Simon, Rodolfo R. Llinas Tags: Biological Sciences Source Type: research

Guidelines for screening and managing hypertension in children
This article reviews the definition of pediatric hypertension, describes why the guidelines were updated, and defines treatment protocol. By familiarizing themselves with and applying these guidelines, clinicians will be able to appropriately screen and manage hypertension in children to prevent morbidity into adulthood.
Source: Journal of the American Academy of Physician Assistants - December 24, 2020 Category: Primary Care Tags: CME: Pediatrics Source Type: research

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice Neuroscience
Intracerebral hemorrhage (ICH) is a devastating form of stroke affecting millions of people worldwide. Parenchymal hematoma triggers a series of reactions leading to primary and secondary brain injuries and permanent neurological deficits. Microglia and macrophages carry out hematoma clearance, thereby facilitating functional recovery after ICH. Here, we elucidate a pivotal...
Source: Proceedings of the National Academy of Sciences - December 22, 2020 Category: Science Authors: Jing Xu, Zhouqing Chen, Fang Yu, Huan Liu, Cheng Ma, Di Xie, Xiaoming Hu, Rehana K. Leak, Sherry H. Y. Chou, R. Anne Stetler, Yejie Shi, Jun Chen, Michael V. L. Bennett, Gang Chen Tags: Biological Sciences Source Type: research

Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade Medical Sciences
Stroke is a leading cause of death and disability. Recovery depends on a delicate balance between inflammatory responses and immune suppression, tipping the scale between brain protection and susceptibility to infection. Peripheral cholinergic blockade of immune reactions fine-tunes this immune response, but its molecular regulators are unknown. Here, we report...
Source: Proceedings of the National Academy of Sciences - December 22, 2020 Category: Science Authors: Katarzyna Winek, Sebastian Lobentanzer, Bettina Nadorp, Serafima Dubnov, Claudia Dames, Sandra Jagdmann, Gilli Moshitzky, Benjamin Hotter, Christian Meisel, David S. Greenberg, Sagiv Shifman, Jochen Klein, Shani Shenhar-Tsarfaty, Andreas Meisel, Hermona S Tags: Biological Sciences Source Type: research

Status epilepticus in neonates and infants
Rajni Farmania, Divyani Garg, Suvasini SharmaAnnals of Indian Academy of Neurology 2020 23(6):747-754 Status epilepticus (SE) is a common neurological emergency in childhood associated with high mortality and morbidity. Acute management of seizures along with aggressive evaluation for establishing the underlying cause are crucial determinants of outcome. Neonatal status epilepticus carries the burden of poor neurological outcomes and may lead to global developmental delay as well as persistent seizures. The aetiology and pathophysiological mechanisms of SE in neonates and young infants differ compared to older children an...
Source: Annals of Indian Academy of Neurology - December 18, 2020 Category: Neurology Authors: Rajni Farmania Divyani Garg Suvasini Sharma Source Type: research

Assessing autonomic nervous function by heart rate variability and heart rate turbulence in patients with acute ischemic stroke
Conclusions: Combined evaluation of HRV and HRT parameters may provide important information regarding the alterations in the ANS in patients with AIS. The utility of HRT in the determination of ANS alterations in patients with AIS should be investigated in larger future prospective studies.
Source: Annals of Indian Academy of Neurology - December 8, 2020 Category: Neurology Authors: Mustafa Candemir Halil Onder Source Type: research

Economic Burden of Acute Stroke Care in Beneficiaries and Non-Beneficiaries under Social Security Schemes at Tertiary Care Hospitals of Western Rajasthan
Conclusion: Public health insurance scheme reduces direct cost of acute stroke care significantly. Severity of stroke and prolonged hospital stay were main cost-driven variables.
Source: Annals of Indian Academy of Neurology - December 8, 2020 Category: Neurology Authors: Divya Goswami Kuldeep Singh Pankaj Bhardwaj Samhita Panda Akhil Goel Nitin Joshi Subhkaran Khichar Inder Puri Source Type: research

Systematic development of structured semi-interactive stroke prevention package for secondary stroke prevention
Conclusion: An implementable complex multilingual patient education material could be developed in a stepwise manner. The efficacy of the package to prevent major adverse cardiovascular events is being tested in the SPRINT INDIA study.
Source: Annals of Indian Academy of Neurology - December 8, 2020 Category: Neurology Authors: Mahesh Pundlik Kate Shweta Jain Verma Deepti Arora PN Sylaja MV Padma Rohit Bhatia Dheeraj Khurana Arvind Sharma Pawan Kumar Ojha Vishnu Renjith Girish Baburao Kulkarni Mohammad Sadiq S Jabeen NC Borah Biman Kanti Ray Meenakshi Sharma Jeyaraj Durai Pandia Source Type: research