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Total 33096 results found since Jan 2013.
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Am J Physiol Renal Physiol. 2023 Oct 1;325(4):i-ii. doi: 10.1152/ajprenal.2023.325.4.AU.NO ABSTRACTPMID:37738000 | DOI:10.1152/ajprenal.2023.325.4.AU
Source: American Journal of Physiology. Renal Physiology - September 22, 2023 Category: Physiology Source Type: research
A deep learning-based approach for rectus abdominis segmentation and distance measurement in ultrasonography
Conclusion: Deep learning model Res-UNet has good reliability in RA segmentation and distance measurement in ultrasound images, with great potential in the clinical diagnosis of DRA.PMID:37736487 | PMC:PMC10509763 | DOI:10.3389/fphys.2023.1246994
Source: Physiological Research - September 22, 2023 Category: Physiology Authors: Fei Wang Rongsong Mao Laifa Yan Shan Ling Zhenyu Cai Source Type: research
Plasticity of gastrointestinal vagal afferents in terms of feeding-related physiology and pathophysiology
J Physiol. 2023 Sep 22. doi: 10.1113/JP284075. Online ahead of print.ABSTRACTGastrointestinal vagal afferents play an important role in communicating food related information from the gut to the brain. This information initiates vago-vagal reflexes essential for gut functions, including gut motility and secretions. These afferents also play a role in energy homeostasis, signalling the arrival, amount and nutrient composition of a meal to the central nervous system where it is processed ultimately leading to termination of a meal. Vagal afferent responses to food related stimuli demonstrate a high degree of plasticity, resp...
Source: The Journal of Physiology - September 22, 2023 Category: Physiology Authors: Amanda J Page Source Type: research
Integrated scheduling of production, inventory and imperfect maintenance based on mutual feedback of supplier and demander in distributed environment
AbstractThe previous research on distributed production scheduling focuses on supply side, ignoring the interconnection of supply side and demand side: the delivery time of spare parts from the supply side will influence the maintenance scheduling of distributed equipment of demand side, while the maintenance scheduling of distributed equipment will affect the scheduling decision of supply of spare parts. In addition, in practice, inventory is an important link between manufacturers and customers. Therefore, we firstly propose an optimal scheduling problem of integrated production, inventory and imperfect maintenance with ...
Source: European Journal of Applied Physiology - September 21, 2023 Category: Physiology Source Type: research
Kidney functional reserve, KFR, and damage biomarkers in subclinical chronic kidney disease complicated by acute kidney injury
Am J Physiol Renal Physiol. 2023 Sep 21. doi: 10.1152/ajprenal.00133.2023. Online ahead of print.ABSTRACTSignificant loss of kidney function is not easily identified by serum creatinine (sCr)-based measurements. In the presence of normal sCr, decreased KFR may identify significant loss of function. We evaluated KFR in experimental subclinical chronic kidney disease (sCKD) before and after brief ischemia-reperfusion injury (IRI). Using fluorescein isothiocyanate (FITC)-labelled sinistrin, GFR was measured transcutaneously before and after adenine induced sCKD, and 1 and 2 weeks after brief IRI, and compared with urinary kid...
Source: American Journal of Physiology. Renal Physiology - September 21, 2023 Category: Physiology Authors: Kylie M Taylor Amy Ym Au Sanjeeva Herath Lena Succar Jasmine Wong Jonathan Erlich Zoltan H Endre Source Type: research
Pharmacological inhibition of the MLL1-menin-interaction aggravates acute kidney injury induced by folic acid and ischemia/reperfusion in mice
In this study, we investigated the role and mechanisms of MLL1 in murine models of acute kidney injury (AKI) induced by folic acid (FA) and ischemia/reperfusion (I/R). Injury to the kidney elevated expression of MLL1, Menin, WDR5 and H3K4Me3, which was accompanied by increased serum creatinine (Scr) and blood urea nitrogen (BUN), renal tubular injury and apoptosis. Pharmacological inhibition of MLL1 activity with MI503 to disrupt the interaction between MLL1 with Menin further increased Scr and BUN levels, enhanced expression of neutrophil gelatinase associated lipocalin and kidney injury molecule-1, and induced more apopt...
Source: American Journal of Physiology. Renal Physiology - September 21, 2023 Category: Physiology Authors: Xiying Hou Binbin Cui Andong Qiu Na Liu Shougang Zhuang Source Type: research
Infusing Sociology into a Physiology Classroom: Teaching the Physiology of Obesity Through a Socioscientific Lens
Adv Physiol Educ. 2023 Sep 21. doi: 10.1152/advan.00093.2023. Online ahead of print.ABSTRACTConventional teaching about obesity, especially within a physiology-based course, tends to focus on the biological aspects. Unfortunately, framing obesity from a solely biological perspective ignores many factors that contribute to the condition, leaving students with an overly simplistic idea. We developed an introductory exercise physiology course that was co-taught with a physiologist and sociologist to provide health science majors with a more holistic view of complex socioscientific issues including obesity. From our course stu...
Source: Advances in Physiology Education - September 21, 2023 Category: Physiology Authors: Andrew M Petzold Shanna L Altrichter Source Type: research
Validated Checklist for Assessing Communication Skills in undergraduate medical students: Bridging the Gap for Effective Doctor-Patient Interactions
In conclusion, the developed checklist proves to be an effective and valid instrument for assessing communication skills in Phase I MBBS students. By integrating this tool into Observed Station Clinical Examinations, medical educators can comprehensively evaluate students' communication behaviors. Moreover, the checklist serves as a valuable resource for bridging the gap between theoretical knowledge and practical application, enabling future physicians to excel in doctor-patient interactions, a crucial aspect of patient-centered care.PMID:37732370 | DOI:10.1152/advan.00140.2023
Source: Advances in Physiology Education - September 21, 2023 Category: Physiology Authors: Archana Chauhan Jarina Begum Shaistha Saiyad Source Type: research
Development of critical thinking skills in human anatomy and physiology
Adv Physiol Educ. 2023 Sep 21. doi: 10.1152/advan.00131.2023. Online ahead of print.ABSTRACTApplication of knowledge skills are highly valued in clinical medicine as indicated by recent changes to licensure and entrance exams for nursing and physician programs (i.e., the NCLEX and MCAT). Such emphasis should be both welcomed and supported by approaches to teaching human anatomy and physiology that emphasize critical thinking skills built upon logic, reasoning, and judgement. The argument for development of these skills is not simply philosophical, rather, such emphasis is strongly supported by a 2016 Johns Hopkins study1 t...
Source: Advances in Physiology Education - September 21, 2023 Category: Physiology Authors: Erik P Silldorff Gerald D Robinson Source Type: research
Zwitterion-doped liquid crystal speckle reducers for immersive displays and vectorial imaging
Light Sci Appl. 2023 Sep 22;12(1):242. doi: 10.1038/s41377-023-01265-5.ABSTRACTLasers possess many attractive features (e.g., high brightness, narrow linewidth, well-defined polarization) that make them the ideal illumination source for many different scientific and technological endeavors relating to imaging and the display of high-resolution information. However, their high-level of coherence can result in the formation of noise, referred to as speckle, that can corrupt and degrade images. Here, we demonstrate a new electro-optic technology for combatting laser speckle using a chiral nematic liquid crystal (LC) dispersed...
Source: Appl Human Sci - September 21, 2023 Category: Physiology Authors: Yihan Jin Nathan P Spiller Chao He Grahame Faulkner Martin J Booth Steve J Elston Stephen M Morris Source Type: research
Temporal optimization of exercise to lower fasting glucose levels
This study examined the effect of exercise timing on evening and overnight glucose concentrations in individuals who were non-obese with normal fasting glucose levels (Non-Ob; n = 18) and individuals with obesity (OB) with impaired fasting glucose levels (OB+IFG) and without (n = 16 and n = 18, respectively). Subjects were studied on three occasions (no exercise (NOEX)), morning exercise (AMEX; 0700 h) and evening exercise (PMEX; 2000 h). The evening meal was provided (1800 h) and blood samples were taken from 1740 to 0700 h and morning endogenous glucose production (EGP) was measured. Glucose and insulin concentrations in...
Source: The Journal of Physiology - September 21, 2023 Category: Physiology Authors: Jill A Kanaley J W Porter N C Winn G Lastra A Chockalingam R J Pettit-Mee G F Petroski C Cobelli M Schiavon E J Parks Source Type: research
Benefits beyond cardiometabolic health: the potential of frequent high intensity 'exercise snacks' to improve outcomes for those living with and beyond cancer
J Physiol. 2023 Sep 21. doi: 10.1113/JP284985. Online ahead of print.ABSTRACTHigh intensity interval training (HIIT) has been shown to consistently elicit rapid and significant adaptations in a number of physiological systems, across many different healthy and clinical populations. In addition, there is increasing interest in how some acute, yet transient responses to high intensity exercise potentially reduce the risks of particular diseases. Recent work has shown that discrete, brief bouts of high intensity exercise (termed 'exercise snacks') can improve glucose control and vascular health and thus counter the negative c...
Source: The Journal of Physiology - September 21, 2023 Category: Physiology Authors: David G Jenkins James L Devin Kathryn L Weston Joseph G Jenkins Tina L Skinner Source Type: research
< em > Glucocorticoids, Their Uses, Sexual Dimorphisms, and Diseases: New Concepts, Mechanisms, and Discoveries < /em >
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00021.2023. Online ahead of print.ABSTRACTThe normal stress response in humans is governed by the hypothalamic-pituitary-adrenal (HPA) axis through heightened mechanisms during stress, raising blood levels of the glucocorticoid hormone cortisol. Glucocorticoids are quintessential compounds that balance the proper functioning of numerous systems in the mammalian body. They are also generated synthetically and are the preeminent therapy for inflammatory diseases. They act by binding to the nuclear receptor transcription factor, the glucocorticoid receptor (GR), which has two mai...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Genesee J Martinez Malik Appleton Zachary A Kipp Analia S Loria Booki Min Terry D Hinds Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
High levels of uric acid inhibit BAT thermogenic capacity through regulation of AMPK
Am J Physiol Endocrinol Metab. 2023 Sep 21. doi: 10.1152/ajpendo.00092.2023. Online ahead of print.ABSTRACTHyperuricemia (HUA) is strongly associated with the increasing prevalence of obesity, but the underlying mechanism remains elusive. Dysfunction of brown adipose tissue (BAT) could lead to obesity. However, studies on the role of HUA on BAT are lacking. Our retrospective clinical analysis showed that serum uric acid (UA) is significantly associated with BAT in humans. To investigate the role of UA in regulating BAT function, we used UA to treat primary brown adipocytes (BAC) in vitro and established HUA mice. In vitro ...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 21, 2023 Category: Physiology Authors: Meijuan Dong Kun An Li Mao Source Type: research
