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Suggested teaching-learning methods for the competencies in "cell membrane" framed by the Australian research endeavor
Adv Physiol Educ. 2023 Dec 1;47(4):761. doi: 10.1152/advan.00155.2023.NO ABSTRACTPMID:37703407 | DOI:10.1152/advan.00155.2023
Source: Advances in Physiology Education - September 13, 2023 Category: Physiology Authors: Krishna Mohan Surapaneni Source Type: research
Advancing physiology education by encouraging student research through outreach activities
Adv Physiol Educ. 2023 Dec 1;47(4):751. doi: 10.1152/advan.00137.2023.NO ABSTRACTPMID:37703406 | DOI:10.1152/advan.00137.2023
Source: Advances in Physiology Education - September 13, 2023 Category: Physiology Authors: Krishna Mohan Surapaneni Source Type: research
"Integration" concepts of physiology as learning competencies across all professional years of medical education
Adv Physiol Educ. 2023 Dec 1;47(4):753. doi: 10.1152/advan.00158.2023.NO ABSTRACTPMID:37703405 | DOI:10.1152/advan.00158.2023
Source: Advances in Physiology Education - September 13, 2023 Category: Physiology Authors: Krishna Mohan Surapaneni Source Type: research
The bHLH Transcription Factor ASCL1 Promotes Differentiation of Endocrine Cells in the Stomach and is Regulated by Notch Signaling
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 12. doi: 10.1152/ajpgi.00043.2023. Online ahead of print.ABSTRACTNotch signaling regulates gastrointestinal stem cell proliferation and differentiation yet Notch-regulated transcriptional effectors of gastric epithelial cell differentiation are poorly understood. Here we tested the role of the bHLH transcription factor achaete-scute homolog 1 (ASCL1) in gastric epithelial cell differentiation, and its regulation by Notch. Newborn Ascl1 null mice showed a loss of expression of markers of neurogenin-3 dependent enteroendocrine cells, with normal expression of enterochromaffin...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Elise S Hibdon Theresa M Keeley Juanita L Merchant Linda C Samuelson Source Type: research
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality
We report that P2Y2 purinergic receptor knockout mice (P2Y2-/-) had attenuated inflammation and liver injury, with improved survival in response to LPS/Galactosamine (LPS/GalN; inflammatory liver injury) and cecal ligation and puncture (CLP; polymicrobial sepsis). P2Y2-/- livers had attenuated JNK activation, MMP-9 expression, and hepatocyte apoptosis in response to LPS/GalN; and attenuated iNOS and NLRP3 protein expression in response to CLP. Implicating liver injury in the disruption of amino acid homeostasis, CLP led to lower serum arginine and higher bacterial load and morbidity in the WT mice, whereas serum arginine l...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Athis R Arunachalam Sanju S Samuel Arunmani Mani Janielle P Maynard Kelsey M Stayer Eric Dybbro Subapradha Narayanan Aalekhya Biswas Saliha Pathan Krishnakant Soni Abu Hena Mostafa Kamal Chandra Shekar R Ambati Nagireddy Putluri Moreshwar S Desai Sundarar Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
The emerging roles of deep crypt secretory cells in colonic physiology
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 12. doi: 10.1152/ajpgi.00093.2023. Online ahead of print.ABSTRACTDeep crypt secretory (DCS) cells are a population of epithelial cells located at the colonic crypt base that share some similarities to Paneth and goblet cells. They were initially defined as c-Kit expressing cells, though subsequent work showed that they are more specifically marked by Reg4 in the murine colon. The best-understood function of DCS cells at present is supporting the stem cell niche by generating Notch and EGF ligands. However, as these cells also express immunoregulatory (e.g. Ccl6) and host de...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Michael A Schumacher Source Type: research
Novel algorithms for improved detection and analysis of fluorescent signal fluctuations
Pflugers Arch. 2023 Sep 13. doi: 10.1007/s00424-023-02855-3. Online ahead of print.ABSTRACTFluorescent dyes and genetically encoded fluorescence indicators (GEFI) are common tools for visualizing concentration changes of specific ions and messenger molecules during intra- as well as intercellular communication. Using advanced imaging technologies, fluorescence indicators are a prerequisite for the analysis of physiological molecular signaling. Automated detection and analysis of fluorescence signals require to overcome several challenges, including correct estimation of fluorescence fluctuations at basal concentrations of ...
Source: Pflugers Archiv : European Journal of Physiology - September 12, 2023 Category: Physiology Authors: Gebhard Stopper Laura C Caudal Phillip Rieder Davide Gobbo Laura Stopper Lisa Felix Katharina Everaerts Xianshu Bai Christine R Rose Anja Scheller Frank Kirchhoff Source Type: research
Skeletal muscle mitochondria in strength athletes: meeting energy needs with mitochondrial morphological changes
J Physiol. 2023 Sep 12. doi: 10.1113/JP285345. Online ahead of print.NO ABSTRACTPMID:37698494 | DOI:10.1113/JP285345
Source: The Journal of Physiology - September 12, 2023 Category: Physiology Authors: Alyse L Lodigiani Joseph C Morrison Source Type: research
The exercise pressor reflex - a pressure-raising mechanism with a limited role in regulating leg perfusion during locomotion in young healthy men
J Physiol. 2023 Sep 12. doi: 10.1113/JP284870. Online ahead of print.ABSTRACTWe investigated the role of the exercise pressor reflex (EPR) in regulating the haemodynamic response to locomotor exercise. Eight healthy participants (23 ± 3 years, V ̇ O 2 max ${\dot V_{{{\mathrm{O}}_{\mathrm{2}}}{\mathrm{max}}}}$ : 49 ± 6 ml/kg/min) performed constant-load cycling exercise (∼36/43/52/98% V ̇ O 2 max ${\dot V_{{{\mathrm{O}}_{\mathrm{2}}}{\mathrm{max}}}}$ ; 4 min each) without (CTRL) and with (FENT) lumbar intrathecal fentanyl attenuating group III/IV locomotor muscle afferent feedback and, thus, the EPR. To avoid differ...
Source: The Journal of Physiology - September 12, 2023 Category: Physiology Authors: Taylor S Thurston Joshua C Weavil Vincent P Georgescu Hsuan-Yu Wan Nathaniel M Birgenheier Candice K Morrissey Jacob E Jessop Markus Amann Source Type: research
Understanding the hypothalamic-brainstem bridge in the hypoxia puzzle
J Physiol. 2023 Sep 12. doi: 10.1113/JP285387. Online ahead of print.NO ABSTRACTPMID:37698923 | DOI:10.1113/JP285387
Source: The Journal of Physiology - September 12, 2023 Category: Physiology Authors: Daniel B Zoccal Source Type: research
The bHLH Transcription Factor ASCL1 Promotes Differentiation of Endocrine Cells in the Stomach and is Regulated by Notch Signaling
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 12. doi: 10.1152/ajpgi.00043.2023. Online ahead of print.ABSTRACTNotch signaling regulates gastrointestinal stem cell proliferation and differentiation yet Notch-regulated transcriptional effectors of gastric epithelial cell differentiation are poorly understood. Here we tested the role of the bHLH transcription factor achaete-scute homolog 1 (ASCL1) in gastric epithelial cell differentiation, and its regulation by Notch. Newborn Ascl1 null mice showed a loss of expression of markers of neurogenin-3 dependent enteroendocrine cells, with normal expression of enterochromaffin...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Elise S Hibdon Theresa M Keeley Juanita L Merchant Linda C Samuelson Source Type: research
P2Y2 purinergic receptor gene deletion protects mice from bacterial endotoxin and sepsis-associated liver injury and mortality
We report that P2Y2 purinergic receptor knockout mice (P2Y2-/-) had attenuated inflammation and liver injury, with improved survival in response to LPS/Galactosamine (LPS/GalN; inflammatory liver injury) and cecal ligation and puncture (CLP; polymicrobial sepsis). P2Y2-/- livers had attenuated JNK activation, MMP-9 expression, and hepatocyte apoptosis in response to LPS/GalN; and attenuated iNOS and NLRP3 protein expression in response to CLP. Implicating liver injury in the disruption of amino acid homeostasis, CLP led to lower serum arginine and higher bacterial load and morbidity in the WT mice, whereas serum arginine l...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Athis R Arunachalam Sanju S Samuel Arunmani Mani Janielle P Maynard Kelsey M Stayer Eric Dybbro Subapradha Narayanan Aalekhya Biswas Saliha Pathan Krishnakant Soni Abu Hena Mostafa Kamal Chandra Shekar R Ambati Nagireddy Putluri Moreshwar S Desai Sundarar Source Type: research
Farnesoid X receptor enhances epithelial ACE2 expression and inhibits viral-induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2
CONCLUSION: By virtue of its ability to modulate epithelial ACE2 expression and inhibit virus-mediated pro-inflammatory cytokine release, FXR represents a promising target for development of new approaches to prevent intestinal manifestations of SARS-CoV-2.PMID:37697930 | DOI:10.1152/ajpgi.00099.2023
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Jessica S Smyth Jennifer K Truong Anuradha Rao Jennifer Foulke-Abel Luciano Adorini Mark Donowitz Paul A Dawson Stephen J Keely Source Type: research
The emerging roles of deep crypt secretory cells in colonic physiology
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 12. doi: 10.1152/ajpgi.00093.2023. Online ahead of print.ABSTRACTDeep crypt secretory (DCS) cells are a population of epithelial cells located at the colonic crypt base that share some similarities to Paneth and goblet cells. They were initially defined as c-Kit expressing cells, though subsequent work showed that they are more specifically marked by Reg4 in the murine colon. The best-understood function of DCS cells at present is supporting the stem cell niche by generating Notch and EGF ligands. However, as these cells also express immunoregulatory (e.g. Ccl6) and host de...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Michael A Schumacher Source Type: research
