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Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads
This study offers potential applications of the model to investigate cardiac muscle response to hemodynamic coupling between systemic and pulmonary circulations in an in vitro setting.PMID:37712924 | DOI:10.1152/ajpheart.00272.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Amy S Garrett Jarrah Dowrick Andrew J Taberner June-Chiew Han Source Type: research
Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system
In this study, we utilize a well-established and validated one-dimensional blood flow and pulse wave computational model of the circulatory system in order to address how age-related changes in cardiac function and vasculature affect the underlying mechanisms involved in the LV-aorta-brain hemodynamic coupling. Our results reveal how LV contractility affects pulsatile energy transmission to the brain, even with preserved cardiac output. Our model demonstrates the existence of an optimal heart rate (near the normal human heart rate) that minimizes pulsatile energy transmission to the brain at different contractility levels....
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Arian Aghilinejad Faisal Amlani Sohrab P Mazandarani Kevin S King Niema M Pahlevan Source Type: research
Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation
Am J Physiol Heart Circ Physiol. 2023 Sep 15. doi: 10.1152/ajpheart.00199.2023. Online ahead of print.ABSTRACTCigarette smoke exposure is a well-known risk factor for developing numerous chronic health conditions, including pulmonary disease and cardiometabolic disorders. However, the cellular mechanisms mediating the toxicity of cigarette smoke in extra-pulmonary tissues are still poorly understood. Therefore, the purpose of this study was to characterize the acute dose-dependent toxicity of cigarette smoke on mitochondrial metabolism by determining the susceptibility and sensitivity of mitochondrial respiration from muri...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Stephen T Decker Alexs A Matias Adolfo E Cuadra Sean T Bannon Jack P Madden M Enes Erol Corinna Serviente Karine Fenelon Gwenael Layec Source Type: research
Sexual dimorphism in doxorubicin cardiotoxicity: two sides of a complex coin
Am J Physiol Heart Circ Physiol. 2023 Sep 15. doi: 10.1152/ajpheart.00566.2023. Online ahead of print.NO ABSTRACTPMID:37712921 | DOI:10.1152/ajpheart.00566.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Ambra Costa Pietro Ameri Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads
This study offers potential applications of the model to investigate cardiac muscle response to hemodynamic coupling between systemic and pulmonary circulations in an in vitro setting.PMID:37712924 | DOI:10.1152/ajpheart.00272.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Amy S Garrett Jarrah Dowrick Andrew J Taberner June-Chiew Han Source Type: research
Tissue Transglutaminase: A Multifunctional and Multisite Regulator in Health and Disease
In conclusion, TG2 provides a multifunctional and multisite response to physiological stress.PMID:37712623 | DOI:10.1152/physrev.00003.2023
Source: Physiological Reviews - September 15, 2023 Category: Physiology Authors: Zhouzhou Yao Yuhua Fan Lizhen Lin Rodney E Kellems Yang Xia Source Type: research
Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system
In this study, we utilize a well-established and validated one-dimensional blood flow and pulse wave computational model of the circulatory system in order to address how age-related changes in cardiac function and vasculature affect the underlying mechanisms involved in the LV-aorta-brain hemodynamic coupling. Our results reveal how LV contractility affects pulsatile energy transmission to the brain, even with preserved cardiac output. Our model demonstrates the existence of an optimal heart rate (near the normal human heart rate) that minimizes pulsatile energy transmission to the brain at different contractility levels....
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Arian Aghilinejad Faisal Amlani Sohrab P Mazandarani Kevin S King Niema M Pahlevan Source Type: research
Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation
Am J Physiol Heart Circ Physiol. 2023 Sep 15. doi: 10.1152/ajpheart.00199.2023. Online ahead of print.ABSTRACTCigarette smoke exposure is a well-known risk factor for developing numerous chronic health conditions, including pulmonary disease and cardiometabolic disorders. However, the cellular mechanisms mediating the toxicity of cigarette smoke in extra-pulmonary tissues are still poorly understood. Therefore, the purpose of this study was to characterize the acute dose-dependent toxicity of cigarette smoke on mitochondrial metabolism by determining the susceptibility and sensitivity of mitochondrial respiration from muri...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Stephen T Decker Alexs A Matias Adolfo E Cuadra Sean T Bannon Jack P Madden M Enes Erol Corinna Serviente Karine Fenelon Gwenael Layec Source Type: research
Sexual dimorphism in doxorubicin cardiotoxicity: two sides of a complex coin
Am J Physiol Heart Circ Physiol. 2023 Sep 15. doi: 10.1152/ajpheart.00566.2023. Online ahead of print.NO ABSTRACTPMID:37712921 | DOI:10.1152/ajpheart.00566.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Ambra Costa Pietro Ameri Source Type: research
Isolated cardiac muscle contracting against a real-time model of systemic and pulmonary cardiovascular loads
This study offers potential applications of the model to investigate cardiac muscle response to hemodynamic coupling between systemic and pulmonary circulations in an in vitro setting.PMID:37712924 | DOI:10.1152/ajpheart.00272.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Amy S Garrett Jarrah Dowrick Andrew J Taberner June-Chiew Han Source Type: research
Mechanistic insights on age-related changes in heart-aorta-brain hemodynamic coupling using a pulse wave model of the entire circulatory system
In this study, we utilize a well-established and validated one-dimensional blood flow and pulse wave computational model of the circulatory system in order to address how age-related changes in cardiac function and vasculature affect the underlying mechanisms involved in the LV-aorta-brain hemodynamic coupling. Our results reveal how LV contractility affects pulsatile energy transmission to the brain, even with preserved cardiac output. Our model demonstrates the existence of an optimal heart rate (near the normal human heart rate) that minimizes pulsatile energy transmission to the brain at different contractility levels....
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Arian Aghilinejad Faisal Amlani Sohrab P Mazandarani Kevin S King Niema M Pahlevan Source Type: research
Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation
Am J Physiol Heart Circ Physiol. 2023 Sep 15. doi: 10.1152/ajpheart.00199.2023. Online ahead of print.ABSTRACTCigarette smoke exposure is a well-known risk factor for developing numerous chronic health conditions, including pulmonary disease and cardiometabolic disorders. However, the cellular mechanisms mediating the toxicity of cigarette smoke in extra-pulmonary tissues are still poorly understood. Therefore, the purpose of this study was to characterize the acute dose-dependent toxicity of cigarette smoke on mitochondrial metabolism by determining the susceptibility and sensitivity of mitochondrial respiration from muri...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Stephen T Decker Alexs A Matias Adolfo E Cuadra Sean T Bannon Jack P Madden M Enes Erol Corinna Serviente Karine Fenelon Gwenael Layec Source Type: research
Sexual dimorphism in doxorubicin cardiotoxicity: two sides of a complex coin
Am J Physiol Heart Circ Physiol. 2023 Sep 15. doi: 10.1152/ajpheart.00566.2023. Online ahead of print.NO ABSTRACTPMID:37712921 | DOI:10.1152/ajpheart.00566.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 15, 2023 Category: Physiology Authors: Ambra Costa Pietro Ameri Source Type: research
