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Total 33096 results found since Jan 2013.

Spatiotemporally quantitative < em > in vivo < /em > imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00147.2023. Online ahead of print.ABSTRACTMitochondrial fatty acid β-oxidation (FAO) plays a key role in energy homeostasis. Several FAO evaluation methods are currently available, but they are not necessarily suitable for capturing the dynamics of FAO in vivo at a cellular-level spatial resolution and seconds-level time resolution. FAOBlue is a coumarin-based probe that undergoes β-oxidation to produce a fluorescent substrate, 7-hydroxycoumarin-3-(N-(2-hydroxyethyl))-carboxamide (7-HC). After confirming that 7-HC could be specifically detected using multip...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ayumi Matsumoto Isao Matsui Shohei Uchinomiya Yusuke Katsuma Seiichi Yasuda Hiroki Okushima Atsuhiro Imai Takeshi Yamamoto Akio Ojida Kazunori Inoue Yoshitaka Isaka Source Type: research

Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity
This study compared high-intensity interval training (HIIT) with more conventional moderate-intensity continuous training (MICT) on intramyocellular lipid content, as well as LD characteristics (size and number) and abundance within the intramyofibrillar (IMF) and subsarcolemmal (SS) regions of type I and type II skeletal muscle fibers in adults with obesity. Thirty-six adults with obesity (BMI=33±3 kg/m2) completed 12 weeks (4d/week) of either HIIT (10x1 min, 90% HRmax + 1 min active recovery; n=19) or MICT (45 min steady-state exercise, 70% HRmax; n=17), while on a weight-maintaining diet throughout training. Skeletal m...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Michael W Schleh Cheehoon Ahn Benjamin J Ryan Olivia K Chugh Austin T Luker Kathryn E Luker Jenna B Gillen Alison C Ludzki Douglas W Van Pelt Lisa M Pitchford Tao Zhang Thomas Rode Suzette M Howton Charles F Burant Jeffrey F Horowitz Source Type: research

Hypoxic sensitivity and burden predict propensity for respiratory plasticity in humans
J Physiol. 2023 Sep 18. doi: 10.1113/JP285492. Online ahead of print.NO ABSTRACTPMID:37723606 | DOI:10.1113/JP285492
Source: The Journal of Physiology - September 19, 2023 Category: Physiology Authors: Ken D O'Halloran Source Type: research

Effects of < em > in utero < /em > exposure to fluoxetine on the gastrointestinal tract of rat offspring
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 19. doi: 10.1152/ajpgi.00223.2022. Online ahead of print.ABSTRACTPerinatal exposure to selective serotonin reuptake inhibitors (SSRIs) has been shown to disrupt the development of serotonergic signaling pathways. Serotonin (5-hydroxytryptamine; 5-HT) signaling is critical for gastrointestinal homeostasis; changes in 5-HT expression and regulation have been associated with gastrointestinal diseases of motility and inflammation. We tested the hypothesis that perinatal exposure to the SSRI, fluoxetine, can influence the development of the gastrointestinal tract in exposed offs...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 19, 2023 Category: Physiology Authors: Katherine L Prowse Harriett Law Sergio Raez-Villanueva Filip Markovic Megan Wang Rajka Borojevic Sean P Parsons Alexander D Vincent Alison C Holloway Elyanne M Ratcliffe Source Type: research

Mechanisms of cardiac collapse at high temperature in a marine teleost (Girella nigrians)
Comp Biochem Physiol A Mol Integr Physiol. 2023 Sep 17:111512. doi: 10.1016/j.cbpa.2023.111512. Online ahead of print.ABSTRACTHeat-induced mortality in ectotherms may be attributed to impaired cardiac performance, specifically a collapse in maximum heart rate (fHmax), although the physiological mechanisms driving this phenomenon are still unknown. Here, we tested two proposed factors which may restrict cardiac upper thermal limits: noxious venous blood conditions and oxygen limitation. We hypothesized elevated blood [K+] (hyperkalemia) and low oxygen (hypoxia) would reduce cardiac upper thermal limits in a marine teleost (...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - September 19, 2023 Category: Physiology Authors: Gail D Schwieterman Emily A Hardison Georgina K Cox Jacey C Van Wert Kim Birnie-Gauvin Erika J Eliason Source Type: research

The separation and identification of circulating small extracellular vesicles from endurance-trained, strength-trained and recreationally active men
This study examined the abundance, and a targeted metabolomic profile, of small EVs separated from the blood of endurance athletes, strength athletes and recreationally active controls at rest (∼40 h after the most recent exercise session) on two separate but identical lab visits. No differences were observed in the abundance or metabolomic profile of small EV preparations between the groups or between the lab visits within each group. Further research should determine whether the bioactive cargoes (e.g. RNA, protein and additional metabolites) carried within EVs are altered in individuals with divergent histories of exe...
Source: The Journal of Physiology - September 19, 2023 Category: Physiology Authors: Ian A J Darragh Niamh McNamee R óisín Daly Sarai Martinez Pacheco Lorraine O'Driscoll Brendan Egan Source Type: research

Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype
J Physiol. 2023 Sep 19. doi: 10.1113/JP285104. Online ahead of print.ABSTRACTCurrently, all salivary ducts (intercalated, striated and collecting) are assumed to function broadly in a similar manner, reclaiming ions that were secreted by the secretory acinar cells while preserving fluid volume and delivering saliva to the oral cavity. Nevertheless, there has been minimal investigation into the structural and functional differences between distinct types of salivary duct cells. Therefore, in this study, the expression profile of proteins involved in stimulus-secretion coupling, as well as the function of the intercalated du...
Source: The Journal of Physiology - September 19, 2023 Category: Physiology Authors: Amanda M Wahl Takahiro Takano Shan Su Blake M Warner Paola Perez James Sneyd David I Yule Source Type: research

Diet composition during the early post-nursing period: in male mice, macronutrients matter
J Physiol. 2023 Sep 18. doi: 10.1113/JP285540. Online ahead of print.NO ABSTRACTPMID:37723409 | DOI:10.1113/JP285540
Source: The Journal of Physiology - September 18, 2023 Category: Physiology Authors: Elliott S Neal Dayna A Zimmerman Rebecca L Brady Source Type: research

The mega-evolution of life with its three memory systems depends on sender-receiver communication and problem-solving. A narrative review
J Physiol. 2023 Sep 18. doi: 10.1113/JP284412. Online ahead of print.ABSTRACTIt should be the ultimate goal of any theory of evolution to delineate the contours of an integrative system to answer the question: How does life (in all its complexity) evolve (which can be called mega-evolution)? But how to plausibly define 'life'? My answer (1994-2023) is: 'life' sounds like a noun, but denotes an activity, and thus is a verb. Life (L) denotes nothing else than the total sum (∑) of all acts of communication (transfer of information) (C) executed by any type of senders-receivers at all their levels (up to at least 15) of comp...
Source: The Journal of Physiology - September 18, 2023 Category: Physiology Authors: Arnold De Loof Source Type: research

The Therapeutic Role of Inspiratory Muscle Training in The Management of Asthma: A Narrative Review
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00325.2022. Online ahead of print.ABSTRACTAsthma is a disorder of the airways characterized by chronic airway inflammation, hyperresponsiveness, and variable recurring airway obstruction. Treatment options for asthma include pharmacological strategies, while non-pharmacological strategies are limited. Established pharmacological approaches to treating asthma may cause unwanted side effects and do not always afford adequate protection against asthma, possibly due to an individual's variable response to medications. A potential non-pharmacological inte...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Abigail S Sogard Timothy D Mickleborough Source Type: research

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00137.2023. Online ahead of print.ABSTRACTPostnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-l...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Alisha A Ziegler Samuel B R Lawton Connie C Grobe John J Reho Bonnie P Freudinger Colin M L Burnett Pablo Nakagawa Justin L Grobe Jeffrey L Segar Source Type: research

Ponderings on Peer Review: Part 3. Grant Critiques
The objective of stage 1 of the process is to establish the scientific merit of the grant proposal. For that phase, I discuss grant review panels, reviewer qualifications and responsibilities, how reviewers are identified and selected, pre-review meeting activities, activities during the review panel meeting, grant review criteria and scoring scales, and post-meeting activities. I also note 2 mechanisms that provide "pre-peer review" advice and recommendations for grant applications under development. I then describe the events associated with stage 2 of the peer review process in which grant funding agencies consider appl...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Douglas R Seals Source Type: research

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