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Total 33096 results found since Jan 2013.

Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets
Conclusion Our modeling of the modulation of the tick regulome in response to A. phagocytophilum infection provided new insights into the mechanisms that target specific functions in different tick tissues. These results supported the use of network analysis for the study of regulome response to infection. Although general mechanisms affected by A. phagocytophilum infection may be conserved even between tick and human cells (de la Fuente et al., 2016b), the effect of vector-pathogen co-evolution on pathogen isolates adaptation to grow in tick cells (Alberdi et al., 2015) may result in differences between isolates in the m...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Knockdown of mineralocorticoid or angiotensin II type 1 receptor gene expression in the paraventricular nucleus prevents angiotensin II hypertension in rats.
This article is protected by copyright. All rights reserved. PMID: 24973408 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 27, 2014 Category: Physiology Authors: Chen A, Huang BS, Wang HW, Ahmad M, Leenen FH Tags: J Physiol Source Type: research

Mineralocorticoid and angiotensin II type 1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarction.
This article is protected by copyright. All rights reserved. PMID: 24951624 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 20, 2014 Category: Physiology Authors: Huang BS, Chen A, Ahmad M, Wang HW, Leenen FH Tags: J Physiol Source Type: research

Gold nanorod delivery of LSD1 siRNA induces human mesenchymal stem cell differentiation.
In this study, we have developed poly-sodium 4-styrenesulfonate (PSS) and poly-allylamine hydrochloride (PAH) coated AuNR-based nanocarriers, which are capable of delivering small interfering RNA (siRNA) against LSD1 to induce the differentiation of human mesenchymal stem cells. To further study the mechanism, we tested the stemness and differentiation genes and found that they have been changed with LSD1 down-regulation. In addition, with the hepatocyte growth factor (HGF), LSD1 siRNA delivery by AuNRs could promote the differentiation of the human mesenchymal stem cells (human MSCs) into a hepatocyte lineage in vitro. Ou...
Source: Appl Human Sci - June 7, 2015 Category: Physiology Authors: Zhao X, Huang Q, Jin Y Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

Myosin light chain kinase controls voltage-dependent calcium channels in vascular smooth muscle.
This study was designed to investigate whether MLCK is involved in Ca(2+) regulation in resistance artery smooth muscle cell, which plays a major role in the control of blood pressure. As ML compounds were shown to have off-target effects, MLCK was downregulated by transfection with a small interfering RNA targeting MLCK (MLCK-siRNA) in rat small resistance mesenteric artery (RMA) and in the rat embryonic aortic cell line A7r5. Noradrenaline-induced contraction and Ca(2+) signal were significantly depressed in MLCK-siRNA compared to scramble-siRNA-transfected RMA. Contraction and Ca(2+) signal induced by high KCl and volta...
Source: Pflugers Archiv : European Journal of Physiology - October 27, 2013 Category: Physiology Authors: Martinsen A, Schakman O, Yerna X, Dessy C, Morel N Tags: Pflugers Arch Source Type: research

siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases?
Abstract Alzheimers, cancer, acquired immune deficiency syndrome (AIDS) are considered to be some of the most deadly diseases of the 21st century on account of their severity and rapid increase in the number of affected population and with scarce cases of recovery, they still remain a troubling paradox. Specifically, with millions of cancer patients worldwide and lack of proper cure for the same, understanding the deadly disease at the molecular level and planning a therapeutic strategy in the same line is the need of the hour. Further, the potential threat of prevalence and escalation of Alzheimer's and HIV (huma...
Source: Appl Human Sci - May 11, 2017 Category: Physiology Authors: Acharya R, Saha S, Ray S, Hazra S, Mitra MK, Chakraborty J Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

Dimethylaminoethyl modified curdlan nanoparticles for targeted siRNA delivery to macrophages.
Abstract Curdlan, an insoluble and neutral polysaccharide, was produced from Agrobacterium sp. ATCC 31750 and chemically modified with dimethylaminoethyl (DMAE) group to introduce gene binding ability. The resulting DMAE-curdlan was crosslinked with curdlan nanoparticles using epichlorohydrin. The prepared nanoparticles are spherical with an average diameter of 523 ± 195 nm, stable and are highly biocompatible with differentiated THP-1 macrophages with viability of above 90%. They are taken up more efficiently by RAW 264.7 macrophage cells than by L929 fibroblast cells. They increase the expression of M1 ma...
Source: Appl Human Sci - January 13, 2020 Category: Physiology Authors: Yunus Basha R, Venkatachalam G, Sampath Kumar TS, Doble M Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

Temporal effects of sugar intake on fly local search and honey bee dance behaviour
This study aimed to investigate the temporal dynamics of the initiation of sugar-elicited search and dance behaviour, using a comparative approach. Passive displacement experiments showed that feeding and the initiation of search could be spatially and temporally dissociated. Sugar intake increased the probability of initiating a search but the actual onset of walking triggers the path integration system to guide the search. When prevented from walking after feeding, flies and bees maintained their motivation for a path integration-based search for a duration of 3 min. In flies, turning and associated characters were signi...
Source: Physiological Research - August 25, 2023 Category: Physiology Authors: Manal Shakeel Axel Brockmann Source Type: research