siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases?

siRNA-nanoparticle conjugate in gene silencing: A future cure to deadly diseases? Mater Sci Eng C Mater Biol Appl. 2017 Jul 01;76:1378-1400 Authors: Acharya R, Saha S, Ray S, Hazra S, Mitra MK, Chakraborty J Abstract Alzheimers, cancer, acquired immune deficiency syndrome (AIDS) are considered to be some of the most deadly diseases of the 21st century on account of their severity and rapid increase in the number of affected population and with scarce cases of recovery, they still remain a troubling paradox. Specifically, with millions of cancer patients worldwide and lack of proper cure for the same, understanding the deadly disease at the molecular level and planning a therapeutic strategy in the same line is the need of the hour. Further, the potential threat of prevalence and escalation of Alzheimer's and HIV (human immunodeficiency virus) infection by more than three times as of recent past, needs a medical breakthrough to arrive at a meaningful solution to tackle the present day scenario. It is evident that these diseases initiate and propagate based on certain genes and their expression which needs to be silenced by the help of small interfering RNA (siRNA) by at least 70%. For short term silencing of the protein coding genes, siRNA is the most appropriate tool. Hence, the present communication explores the possibility for treatment and cure of a plethora of deadly diseases, e.g., cancer, including Alzheimer's and AIDS to some ...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research