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Total 33096 results found since Jan 2013.
The effect of exercise on vascular health in chronic kidney disease: a systematic review and meta-analysis of randomized controlled trials
Am J Physiol Renal Physiol. 2023 Sep 21. doi: 10.1152/ajprenal.00152.2023. Online ahead of print.ABSTRACTPatients with chronic kidney disease (CKD) are at increased risk of cardiovascular disease. This increased risk cannot be fully explained by traditional risk factors such as hypertension. Endothelial dysfunction and arterial stiffness have been suggested as factors which explain some of the increased risk, and are independently associated with important cardiovascular outcomes in CKD patients. Studies in other disease populations have shown positive effects of exercise on vascular dysfunction. The aim of this review was...
Source: American Journal of Physiology. Renal Physiology - September 21, 2023 Category: Physiology Authors: Mark D Davies Felicity Hughes Aamer Sandoo Abdulfattah Alejmi Jamie Hugo Macdonald Source Type: research
Does radiation therapy affect adhesion of tricalcium silicate cements to root dentin?
CONCLUSION: The push-out bond strength of Biodentine and MTA to root canal dentin decreased significantly post irradiation.PMID:37729257 | DOI:10.1590/1678-7757-2023-0118
Source: Appl Human Sci - September 20, 2023 Category: Physiology Authors: Lochan Khullar Nidambur Vasudev Ballal Tan F ırat Eyüboğlu Mutlu Özcan Source Type: research
The nervous system and adipose tissues: a tale of dialogues
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00115.2023. Online ahead of print.ABSTRACTWhite, beige and brown adipose tissues play a crucial role in maintaining energy homeostasis. Due to the heterogeneous and diffuse nature of fat pads, this balance requires a fine and coordinated control of many actors and therefore permanent dialogues between these tissues and the central nervous system. For about two decades many studies have been devoted to describe the neuro-anatomical and functional complexity involved to ensure this dialogue. Thus, if it is now clearly demonstrated that there is an efferent symp...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Anne Lorsignol Lise Rabiller Elodie Labit Louis Casteilla Luc Penicaud Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
Meal sugar-protein balance determines postprandial FGF21 response in humans
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00241.2023. Online ahead of print.ABSTRACTBiological mechanisms that regulate dietary balance remain unclear. FGF21 is suggested to contribute to such potential regulation considering that FGF21 1) is genetically associated with carbohydrate/sugar and protein intake in opposite directions, 2) is secreted after sugar ingestion and protein restriction, and 3) pharmacologically reduces sugar and increases protein intake in rodents. To gain insight of the nature of this potential regulation, we aimed to study macronutrient interactions in the secretory regulation...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Stina Ramne Lisanne Duizer Mette S Nielsen Niklas Rye J ørgensen Jens S Svenningsen Niels Grarup Anders Sj ödin Anne Raben Matthew P Gillum Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
Spatiotemporally quantitative < em > in vivo < /em > imaging of mitochondrial fatty acid β-oxidation at cellular-level resolution in mice
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00147.2023. Online ahead of print.ABSTRACTMitochondrial fatty acid β-oxidation (FAO) plays a key role in energy homeostasis. Several FAO evaluation methods are currently available, but they are not necessarily suitable for capturing the dynamics of FAO in vivo at a cellular-level spatial resolution and seconds-level time resolution. FAOBlue is a coumarin-based probe that undergoes β-oxidation to produce a fluorescent substrate, 7-hydroxycoumarin-3-(N-(2-hydroxyethyl))-carboxamide (7-HC). After confirming that 7-HC could be specifically detected using multip...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ayumi Matsumoto Isao Matsui Shohei Uchinomiya Yusuke Katsuma Seiichi Yasuda Hiroki Okushima Atsuhiro Imai Takeshi Yamamoto Akio Ojida Kazunori Inoue Yoshitaka Isaka Source Type: research
Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity
This study compared high-intensity interval training (HIIT) with more conventional moderate-intensity continuous training (MICT) on intramyocellular lipid content, as well as LD characteristics (size and number) and abundance within the intramyofibrillar (IMF) and subsarcolemmal (SS) regions of type I and type II skeletal muscle fibers in adults with obesity. Thirty-six adults with obesity (BMI=33±3 kg/m2) completed 12 weeks (4d/week) of either HIIT (10x1 min, 90% HRmax + 1 min active recovery; n=19) or MICT (45 min steady-state exercise, 70% HRmax; n=17), while on a weight-maintaining diet throughout training. Skeletal m...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Michael W Schleh Cheehoon Ahn Benjamin J Ryan Olivia K Chugh Austin T Luker Kathryn E Luker Jenna B Gillen Alison C Ludzki Douglas W Van Pelt Lisa M Pitchford Tao Zhang Thomas Rode Suzette M Howton Charles F Burant Jeffrey F Horowitz Source Type: research
Can the exercise pressor reflex still go with the flow?
J Physiol. 2023 Sep 20. doi: 10.1113/JP285530. Online ahead of print.NO ABSTRACTPMID:37728309 | DOI:10.1113/JP285530
Source: The Journal of Physiology - September 20, 2023 Category: Physiology Authors: Audrey J Stone Milena Samora Source Type: research
The nervous system and adipose tissues: a tale of dialogues
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00115.2023. Online ahead of print.ABSTRACTWhite, beige and brown adipose tissues play a crucial role in maintaining energy homeostasis. Due to the heterogeneous and diffuse nature of fat pads, this balance requires a fine and coordinated control of many actors and therefore permanent dialogues between these tissues and the central nervous system. For about two decades many studies have been devoted to describe the neuro-anatomical and functional complexity involved to ensure this dialogue. Thus, if it is now clearly demonstrated that there is an efferent symp...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Anne Lorsignol Lise Rabiller Elodie Labit Louis Casteilla Luc Penicaud Source Type: research
Mechanisms of action of incretin receptor based dual- and tri-agonists in pancreatic islets
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00236.2023. Online ahead of print.ABSTRACTSimultaneous activation of the incretin G protein coupled receptors via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism with molecules also capable of binding the glucagon receptor. In this scoping review we discuss the cellular mechanisms of action (MOA) underlying the actions of these novel and therapeutically important classes of peptide receptor agonists. Clinical efficacy studies of several UDRAs have demonstrate...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Franco Folli Giovanna Finzi Roberto Manfrini Alessandra Galli Francesca Casiraghi Lucia Centofanti Cesare Berra Paolo Fiorina Alberto Davalli Stefano La Rosa Carla Perego Paul B Higgins Source Type: research
Meal sugar-protein balance determines postprandial FGF21 response in humans
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00241.2023. Online ahead of print.ABSTRACTBiological mechanisms that regulate dietary balance remain unclear. FGF21 is suggested to contribute to such potential regulation considering that FGF21 1) is genetically associated with carbohydrate/sugar and protein intake in opposite directions, 2) is secreted after sugar ingestion and protein restriction, and 3) pharmacologically reduces sugar and increases protein intake in rodents. To gain insight of the nature of this potential regulation, we aimed to study macronutrient interactions in the secretory regulation...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Stina Ramne Lisanne Duizer Mette S Nielsen Niklas Rye J ørgensen Jens S Svenningsen Niels Grarup Anders Sj ödin Anne Raben Matthew P Gillum Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
Can the exercise pressor reflex still go with the flow?
J Physiol. 2023 Sep 20. doi: 10.1113/JP285530. Online ahead of print.NO ABSTRACTPMID:37728309 | DOI:10.1113/JP285530
Source: The Journal of Physiology - September 20, 2023 Category: Physiology Authors: Audrey J Stone Milena Samora Source Type: research
