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Drug: Temodar
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Total 1478 results found since Jan 2013.
Inaugural Results of the Individualized Screening Trial of Innovative Glioblastoma Therapy: A Phase II Platform Trial for Newly Diagnosed Glioblastoma Using Bayesian Adaptive Randomization
CONCLUSION: The INSIGhT design enabled efficient simultaneous testing of three experimental agents using a shared control arm and adaptive randomization. Two investigational arms had superior PFS compared with the control arm, but none demonstrated an OS benefit. The INSIGhT design may promote improved and more efficient therapeutic discovery in glioblastoma. New arms have been added to the trial.PMID:37722087 | DOI:10.1200/JCO.23.00493
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Rifaquat Rahman Lorenzo Trippa Eudocia Q Lee Isabel Arrillaga-Romany Geoffrey Fell Mehdi Touat Christine McCluskey Jennifer Wiley Sarah Gaffey Jan Drappatz Mary R Welch Evanthia Galanis Manmeet S Ahluwalia Howard Colman L Burt Nabors Jaroslaw Hepel Heinri Source Type: research
Temozolomide-based sonodynamic therapy induces immunogenic cell death in glioma
CONCLUSIONS: TMZ-based SDT was capable of triggering ICD in glioma. The discovery of TMZ as a sonosensitizer have shown great promise in the treatment of GBM.PMID:37716612 | DOI:10.1016/j.clim.2023.109772
Source: Clinical Immunology - September 16, 2023 Category: Allergy & Immunology Authors: Yan Zhou Jiji Jiao Rongyan Yang Binli Wen Qiaoli Wu Lixia Xu Xiaoguang Tong Hua Yan Source Type: research
Treatment of inoperable large cell neuroendocrine lung cancer with single agent temozolomide
Acta Oncol. 2023 Sep 15:1-4. doi: 10.1080/0284186X.2023.2258444. Online ahead of print.NO ABSTRACTPMID:37713358 | DOI:10.1080/0284186X.2023.2258444
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Annika Marie Ørting Malene Martini Clausen Patrick Soldath Rene H Petersen Ulrich Knigge Mikkel Andreassen Andreas Kj ær Seppo W Langer Source Type: research
Cordycepin improves sensitivity to temozolomide in glioblastoma cells by down-regulating MYC
CONCLUSION: Cordycepin combined with temozolomide may down-regulate MYC through "MicroRNA in cancer, Proteoglycans in cancer, Pathways in cancer and PI3K-AKT signaling pathway", which in turn regulate the expression of MCL1, CTNNB1, MMP9, PDCD4, thus regulating cell proliferation, migration and apoptosis in glioblastoma.PMID:37695389 | DOI:10.1007/s00432-023-05347-0
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Shi-Xing Zheng Jing Chen Bing-Bo Zhuang Qiang Zhang Song-Sheng Shi Guo-Liang Zhang Source Type: research
Efficacy of Capecitabine and Temozolomide Regimen in Neuroendocrine Tumors: Data From the Turkish Oncology Group
CONCLUSIONS AND RELEVANCE: The substantial superior outcomes in patients receiving first-line CAPTEM treatment highlight its potential as an effective treatment strategy for patients with metastatic NET.PMID:37676712 | DOI:10.1093/oncolo/oyad257
Source: The Oncologist - September 7, 2023 Category: Cancer & Oncology Authors: Çağlar Ünal Abdulmunir Azizy Senem Karabulut Didem Ta ştekin Arif Aky ıldız Serkan Ya şar Şuayib Yalçın Ey üp Çoban T ürkkan Evrensel Ziya Kalkan Zeynep Oru ç S ümeyra Derin Zeynep Hande Turna Do ğan Bayram Fahriye Tu ğba Köş Mehmet Ali Source Type: research
Co-loading of Temozolomide with Oleuropein or rutin into polylactic acid core-shell nanofiber webs inhibit glioblastoma cell by controlled release
In this study, we developed a nanofiber-based local therapy against GB cells using Oleuropein (OL), and rutin and their combinations with Temozolomide (TMZ). The polylactic acid (PLA) core-shell nanofiber webs were encapsulated with OL (PLAOL), rutin (PLArutin), and TMZ (PLATMZ) by an electrospinning process. A SEM visualized the morphology and the total immersion method determined the release characteristics of PLA webs. Real-time cell tracking analysis for cell growth, dual Acridine Orange/Propidium Iodide staining for cell viability, a scratch wound healing assay for migration capacity, and a sphere formation assay for ...
Source: International Journal of Biological Macromolecules - September 6, 2023 Category: Biochemistry Authors: Melis Ercelik Cagla Tekin Fatma Nur Par ın Busra Mutlu Hazal Y ılmaz Dogan Gulcin Tezcan Secil Ak Aksoy Melisa Gurbuz Kenan Y ıldırım Ahmet Bekar Hasan Kocaeli Mevlut Ozgur Taskapilioglu P ınar Eser Berrin Tunca Source Type: research
Comparative analysis of α-pinene alone and combined with temozolomide in human glioblastoma cells
Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2252152. Online ahead of print.ABSTRACTα-Pinene (PEN) is a phyto compound present in terpene plants. In traditional medicine, PEN has been used for its anti-inflammatory, pain-relieving, and bronchodilator properties. The effect of PEN in combination with temozolomide (TMZ) in glioblastoma multiforme (GBM) cells has been evaluated. The action of the PEN + TMZ combination on cell migration, soft-agar, and cell death was determined in LN229 and U87MG human glioblastoma cells. In combination, PEN with TMZ showed a synergistic inhibitory effect in the GBM cells. The PEN...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Megha Gautam Reema Gabrani Source Type: research
Quality by design engineered, enhanced anticancer activity of temozolomide and resveratrol coloaded NLC and brain targeting via lactoferrin conjugation in treatment of glioblastoma
The objective of the work was to engineer lactoferrin conjugated temozolomide and resveratrol co-loaded NLC for the treatment of glioblastoma using intranasal delivery for brain targeting. Synergistic activity of temozolomide and resveratrol was determined using combination index method and 1:1 ratio was selected. QbD approach was used to formulate and optimize NLC, with minimum particle size, maximum transmittance and entrapment efficiency using Central Composite Rotable Design (CCRD) method. The optimized LTR-NLC had desired average particle size (209.3 nm), narrow PDI along, high percentage transmittance (>95%) and b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - August 30, 2023 Category: Drugs & Pharmacology Authors: Saurabh Mittal Sadia Shah Harlokesh Narayan Yadav Javed Ali Madan Mohan Gupta Sanjula Baboota Source Type: research
Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O < sup > 6 < /sup > -methylguanine-DNA methyltransferase gene in glioblastoma
CONCLUSION: This study provides novel mechanisms to understand methylation in GBM and identifies some biomarkers for the prognosis of two different GBM types, MGMT promoter unmethylated or methylated GBM, by using metabolomics and proteomics analyses.PMID:37641495 | DOI:10.1111/cns.14415
Source: CNS Neuroscience and Therapeutics - August 29, 2023 Category: Neuroscience Authors: Xi Chen Jinli Sun Yukui Li Weichao Jiang Zhangyu Li Jianyao Mao Liwei Zhou Sifang Chen Guowei Tan Source Type: research
