Comparative analysis of α-pinene alone and combined with temozolomide in human glioblastoma cells

Nat Prod Res. 2023 Sep 4:1-6. doi: 10.1080/14786419.2023.2252152. Online ahead of print.ABSTRACTα-Pinene (PEN) is a phyto compound present in terpene plants. In traditional medicine, PEN has been used for its anti-inflammatory, pain-relieving, and bronchodilator properties. The effect of PEN in combination with temozolomide (TMZ) in glioblastoma multiforme (GBM) cells has been evaluated. The action of the PEN + TMZ combination on cell migration, soft-agar, and cell death was determined in LN229 and U87MG human glioblastoma cells. In combination, PEN with TMZ showed a synergistic inhibitory effect in the GBM cells. The PEN + TMZ treatment showed a higher fluorescent intensity and reduced the percentage of wound area closure compared to the compound alone. The compounds in combination also resulted in a reduction in single-cell colony formation. To conclude, the study showed that plant-derived PEN enhanced the effectiveness of standard chemotherapeutic, TMZ, in LN229 and U87MG cells.PMID:37665021 | DOI:10.1080/14786419.2023.2252152

Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Megha Gautam Reema Gabrani Source Type: research