Filtered By:
Drug: Temodar
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 1478 results found since Jan 2013.
FOXO1-miR-506 axis promotes chemosensitivity to temozolomide and suppresses invasiveness in glioblastoma through a feedback loop of FOXO1/miR-506/ETS1/FOXO1
J Zhejiang Univ Sci B. 2023 Aug 15;24(8):698-710. doi: 10.1631/jzus.B2200503.ABSTRACTTo explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments. Cell viability was tested by a cell counting kit-8 (CCK8) kit; migration and invasion were checked by the scratching assay; apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end lab...
Source: J Zhejiang Univ Sci ... - August 8, 2023 Category: Science Authors: Chao Chen Yu'e Liu Hongxiang Wang Xu Zhang Yufeng Shi Juxiang Chen Source Type: research
Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate
Autophagy. 2023 Aug 6:1-20. doi: 10.1080/15548627.2023.2242696. Online ahead of print.ABSTRACTGlioblastoma (GBM) is the most aggressive primary brain tumor, exhibiting a high rate of recurrence and poor prognosis. Surgery and chemoradiation with temozolomide (TMZ) represent the standard of care, but, in most cases, the tumor develops resistance to further treatment and the patients succumb to disease. Therefore, there is a great need for the development of well-tolerated, effective drugs that specifically target chemoresistant gliomas. NEO214 was generated by covalently conjugating rolipram, a PDE4 (phosphodiesterase 4) in...
Source: Autophagy - August 7, 2023 Category: Cytology Authors: Mengting Ou Hee-Yeon Cho Jie Fu Thu Zan Thein Weijun Wang Stephen D Swenson Radu O Minea Apostolos Stathopoulos Axel H Sch önthal Florence M Hofman Liling Tang Thomas C Chen Source Type: research
Global analysis of iron metabolism-related genes identifies potential mechanisms of gliomagenesis and reveals novel targets
CONCLUSION: The study presented a comprehensive view of key regulators underpinning iron metabolism in gliomas and provided new insights into novel therapeutic approaches.PMID:37545464 | DOI:10.1111/cns.14386
Source: CNS Neuroscience and Therapeutics - August 7, 2023 Category: Neuroscience Authors: Jiayue Zhang Liang Zhao Shurui Xuan Zhiyuan Liu Zhenkun Weng Yu Wang Kexiang Dai Aihua Gu Peng Zhao Source Type: research
