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Drug: Temodar
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Total 1478 results found since Jan 2013.
Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance
CONCLUSIONS: The direct intracranial infusion of shikonin has potential as a local therapy for patients with glioblastoma.PMID:37557011 | DOI:10.1016/j.biopha.2023.115296
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 9, 2023 Category: Drugs & Pharmacology Authors: Ryosuke Maeoka Yukiteru Ouji Tsutomu Nakazawa Ryosuke Matsuda Takayuki Morimoto Shohei Yokoyama Shuichi Yamada Fumihiko Nishimura Ichiro Nakagawa Young-Soo Park Masahide Yoshikawa Hiroyuki Nakase Source Type: research
FOXO1-miR-506 axis promotes chemosensitivity to temozolomide and suppresses invasiveness in glioblastoma through a feedback loop of FOXO1/miR-506/ETS1/FOXO1
J Zhejiang Univ Sci B. 2023 Aug 15;24(8):698-710. doi: 10.1631/jzus.B2200503.ABSTRACTTo explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments. Cell viability was tested by a cell counting kit-8 (CCK8) kit; migration and invasion were checked by the scratching assay; apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end lab...
Source: J Zhejiang Univ Sci ... - August 8, 2023 Category: Science Authors: Chao Chen Yu'e Liu Hongxiang Wang Xu Zhang Yufeng Shi Juxiang Chen Source Type: research
Targeting MAGI2-AS3-modulated Akt-dependent ATP-binding cassette transporters as a possible strategy to reverse temozolomide resistance in temozolomide-resistant glioblastoma cells
In conclusion, MAGI2-AS3 reverses TMZ resistance in glioma cells by inactivating the Akt pathway.PMID:37551766 | DOI:10.1002/ddr.22101
Source: Cell Research - August 8, 2023 Category: Cytology Authors: Zhongjun Chen Jingmin Zhou Yu Liu Hongzao Ni Botao Zhou Source Type: research
FOXO1-miR-506 axis promotes chemosensitivity to temozolomide and suppresses invasiveness in glioblastoma through a feedback loop of FOXO1/miR-506/ETS1/FOXO1
J Zhejiang Univ Sci B. 2023 Aug 15;24(8):698-710. doi: 10.1631/jzus.B2200503.ABSTRACTTo explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis, migration, invasion, autophagy, and temozolomide (TMZ) sensitivity in the U251 cell line using in vitro and in vivo experiments. Cell viability was tested by a cell counting kit-8 (CCK8) kit; migration and invasion were checked by the scratching assay; apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end lab...
Source: J Zhejiang Univ Sci ... - August 8, 2023 Category: Science Authors: Chao Chen Yu'e Liu Hongxiang Wang Xu Zhang Yufeng Shi Juxiang Chen Source Type: research
