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Therapy: Gene Therapy

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Total 490 results found since Jan 2013.

Progress on siRNA-based gene therapy targeting secondary injury after intracerebral hemorrhage
Gene Therapy, Published online: 10 November 2021; doi:10.1038/s41434-021-00304-3Progress on siRNA-based gene therapy targeting secondary injury after intracerebral hemorrhage
Source: Gene Therapy - November 10, 2021 Category: Genetics & Stem Cells Authors: Daniyah A. Almarghalani Zahoor A. Shah Source Type: research

Endogenous microRNA triggered enzyme-free DNA logic self-assembly for amplified bioimaging and enhanced gene therapy via in situ generation of siRNAs
Small interfering RNA (siRNA) has emerged as a kind of promising therapeutic agents for cancer therapy. However, the off-target effect and degradation are the main challenges for siRNAs delivery. Herein, an en...
Source: Journal of Nanobiotechnology - September 26, 2021 Category: Nanotechnology Authors: Qinghua Jiang, Shuzhen Yue, Kaixin Yu, Tian Tian, Jian Zhang, Huijun Chu, Zhumei Cui and Sai Bi Tags: Research Source Type: research

Cetuximab-siRNA Conjugate Linked Through Cationized Gelatin Knocks Down KRAS G12C Mutation in NSCLC Sensitizing the Cells Toward Gefitinib
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211041453. doi: 10.1177/15330338211041453.ABSTRACTDelivery of small-interfering RNA (siRNA) has been of great interest in the past decade for effective gene silencing. To overcome synthetic and regulatory challenges posed by nanoparticle-mediated siRNA delivery, antibody-siRNA conjugate (ARC) platform is emerging as a potential siRNA delivery system suitable for clinical translation. Herein, we have developed a delivery technology based on the ARC platform for stable delivery of siRNA called as Gelatin-Antibody Delivery System (GADS). In GADS, positively charged gelatin act...
Source: Technology in Cancer Research and Treatment - September 20, 2021 Category: Cancer & Oncology Authors: K Sreedurgalakshmi R Srikar K Harikrishnan Lakshmi Srinivasan Reena Rajkumari Source Type: research

Genes, Vol. 12, Pages 1290: siRNA Mediate RNA Interference Concordant with Early On-Target Transient Transcriptional Interference
Clarke Exogenous siRNAs are commonly used to regulate endogenous gene expression levels for gene function analysis, genotype–phenotype association studies and for gene therapy. Exogenous siRNAs can target mRNAs within the cytosol as well as nascent RNA transcripts within the nucleus, thus complicating siRNA targeting specificity. To highlight challenges in achieving siRNA target specificity, we targeted an overlapping gene set that we found associated with a familial form of multiple synostosis syndrome type 4 (SYSN4). In the affected family, we found that a previously unknown non-coding gene TOSPEAK/C8orf37AS1 was ...
Source: Genes - August 23, 2021 Category: Genetics & Stem Cells Authors: Zhiming Fang Zhongming Zhao Valsamma Eapen Raymond A. Clarke Tags: Article Source Type: research

Silencing Survivin: a Key Therapeutic Strategy for Cardiac Hypertrophy
In this study, we investigated the involvement of SURV in intracellular signaling of hypertrophic cardiomyocytes and the impact of its transcriptional silencing, laying the foundation for novel target gene therapy in cardiac hypertrophy. Oligonucleotide-based molecules, like theranostic optical nanosensors (molecular beacons) and siRNAs, targeting SURV and OPN mRNAs, were developed. Their diagnostic and therapeutic potential was evaluated in vitro in hypertrophic FGF23-induced human cardiomyocytes and in vivo in transverse aortic constriction hypertrophic mouse model. Engineered erythrocyte was used as shuttle to selective...
Source: Journal of Cardiovascular Translational Research - August 18, 2021 Category: Cardiology Source Type: research

The involvement of epithelial-to-mesenchymal transition in doxorubicin resistance: Possible molecular targets
Eur J Pharmacol. 2021 Jul 13:174344. doi: 10.1016/j.ejphar.2021.174344. Online ahead of print.ABSTRACTConsidering the fact that cancer cells can switch among various molecular pathways and mechanisms to ensure their progression, chemotherapy is no longer effective enough in cancer therapy. As an anti-tumor agent, doxorubicin (DOX) is derived from Streptomyces peucetius and can induce cytotoxicity by binding to topoisomerase enzymes to suppress DNA replication, leading to apoptosis and cell cycle arrest. However, efficacy of DOX in suppressing cancer progression is restricted by development of drug resistance. Cancer cells ...
Source: European Journal of Pharmacology - July 16, 2021 Category: Drugs & Pharmacology Authors: Sepideh Mirzaei Asal Jalal Abadi Mohammad Hossein Gholami Farid Hashemi Amirhossein Zabolian Kiavash Hushmandi Ali Zarrabi Maliheh Entezari Amir Reza Aref Haroon Khan Milad Ashrafizadeh Saeed Samarghandian Source Type: research

Heat-induced manganese-doped magnetic nanocarriers combined with Yap-siRNA for MRI/NIR-guided mild photothermal and gene therapy of hepatocellular carcinoma
Publication date: 15 December 2021Source: Chemical Engineering Journal, Volume 426Author(s): Qian Zhang, Weiyong Zhao, Jin Cheng, Zhoufeng Deng, Ping Zhang, Amin Zhang, Zhi Xu, Shaojun Pan, Xinmei Liao, Daxiang Cui
Source: Chemical Engineering Journal - June 20, 2021 Category: Chemistry Source Type: research

Host-Guest Interaction-Based Dual response core/shell nanoparticles as efficient siRNA carrier for killing breast cancer cells
Colloids Surf B Biointerfaces. 2021 Jun 11;205:111918. doi: 10.1016/j.colsurfb.2021.111918. Online ahead of print.ABSTRACTHow to overcome multiple obstacles to achieve the efficient and safe delivery of therapeutic genes is still the key to gene therapy. To address this issue, a cationic carrier consisting of polyamide-amine (HPAA-peptide-Fc) modified by an enzyme-responsive polypeptide as the core and hyperbranched polyglycerol derivative (CD-HPG) as the shell was synthesized by self-assembly. The obtained HPAA-peptide-HPG could form the compact nanocomplex with siPlk1, thus confirming the stable load of genes and subsequ...
Source: Colloids and Surfaces - June 18, 2021 Category: Biotechnology Authors: Jinglan Liang Chengguang Wu Xiaoyan Zhou Yunfeng Shi Jun Xu Xiang Cai Tingling Fu Dong Ma Wei Xue Source Type: research

Regulation of The Methylation and Expression Levels of the BMPR2 Gene by SIN3a As A Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension
Conclusions: Altogether, our study unveiled the protective/beneficial role of SIN3a in pulmonary hypertension. We also identified a novel and distinct molecular mechanism by which SIN3a regulates BMPR2 in hPASMC. Our study also identified lung-targeted SIN3a gene therapy using AAV1 as a new promising therapeutic strategy for treating patients with PAH.PMID:34078089 | DOI:10.1161/CIRCULATIONAHA.120.047978
Source: Circulation - June 3, 2021 Category: Cardiology Authors: Malik Bisserier Prabhu Mathiyalagan Shihong Zhang Firas Elmastour Peter Dorfm üller Marc Humbert Gregory David Sima Tarzami Thomas Weber Fr édéric Perros Yassine Sassi Susmita Sahoo Lahouaria Hadri Source Type: research

Contactless delivery of plasmid encoding EGFP in vivo by high-intensity pulsed electromagnetic field
In conclusion, feasibility of HI-PEMF was demonstrated for transfection of different tissues (muscle, skin, tumor) and could have great potential in gene therapy and in DNA vaccination.PMID:34058542 | DOI:10.1016/j.bioelechem.2021.107847
Source: Bioelectrochemistry - May 31, 2021 Category: Biochemistry Authors: Matej Kranjc Simona Kranjc Brezar Gregor Ser ša Damijan Miklav čič Source Type: research