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Therapy: Gene Therapy

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Total 490 results found since Jan 2013.

Cold atmospheric plasma mediated cell membrane permeation and gene delivery-empirical interventions and pertinence
Adv Colloid Interface Sci. 2023 Aug 28;320:102989. doi: 10.1016/j.cis.2023.102989. Online ahead of print.ABSTRACTDelivery of genetic material to cells is an integral tool to analyze and reveal the genetic interventions in normal cellular processes and differentiation, disease development and for gene therapy. It has profound applications in pharmaceutical, agricultural, environmental and biotechnological sectors. The major methods relied for gene delivery or transfection requires either viral vectors or xenogenic carrier molecules, which renders probabilistic carcinogenic, immunogenic and toxic effects. A newly evolved phy...
Source: Advances in Colloid and Interface Science - September 7, 2023 Category: Chemistry Authors: P R Sreedevi K Suresh Source Type: research

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine ‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration.
Positron emission tomography is used to study the fate of polyplexes formed by siRNA and modified polyamines. Polyplexes are prepared with either radiolabeled siRNA or radiolabeled polyamines. By comparing biodistribution patterns of labeled siRNA and labeled polyamines conclusions are driven on the stability of the polyplexes in vivo. AbstractPolyamine-based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or ...
Source: Small - August 4, 2023 Category: Nanotechnology Authors: Cristina Simo, Cristian Salvador, Patrizia Andreozzi, Vanessa Gomez ‐Vallejo, Gabriela Romero, Damien Dupin, Jordi Llop, Sergio E. Moya Tags: Research Article Source Type: research

Carbon Dots with Guanidinium and Amino Acid Functional Groups for Targeted Small Interfering RNA Delivery toward Tumor Gene Therapy (Small 31/2023)
This study provides a versatile strategy for tumor-targeted gene therapy.
Source: Small - August 3, 2023 Category: Nanotechnology Authors: Huimin Xu, Jianqiao Chang, Hao Wu, Haoyu Wang, Wenjing Xie, Yunchao Li, Xiaohong Li, Yang Zhang, Louzhen Fan Tags: Frontispiece Source Type: research

E-258 Endovascular approach to drug delivery to the brain
ConclusionsCPA delivery of AAV9 resulted in increased transduction of the parietal and cingulate cortex, comparable to that observed with CM injections. These results provide preliminary evidence that CPA infusion of gene therapy, and potentially other therapies such as antisense oligonucleotides or siRNA medications, is safe and provides widespread distribution throughout the brain.Abstract E-258 Figure 1Disclosures A. Malek: 4; C; CereVasc. H. Benatti: None. V. Anagnostakou: None. E. Hall: None. C. Heilman: 4; C; CereVasc. B. Beneduce: 4; C; CereVasc. A. Leporati: None. R. King: None. M. Gounis: 1; C; Research support fr...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Malek, A., Benatti, H., Anagnostakou, V., Hall, E., Heilman, C., Beneduce, B., Leporati, A., King, R., Gounis, M., Gray-Edwards, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

The Role of Small Interfering RNAs in Hepatocellular Carcinoma
ConclusionsThis paper mainly reviews the research on HCC treatment based on siRNA in recent years, and summarizes and classifies the HCC treatment targets and siRNA delivery systems.
Source: Journal of Gastrointestinal Cancer - July 11, 2023 Category: Cancer & Oncology Source Type: research

Characterization of PDL1 enhanced siRNA/albumin liposome for effective therapeutic function in lung cancer
ConclusionThe results showed that the PDL1-targeted albumin liposome could be used as a high efficient delivery vector of siRNA, and was a high efficient and safe nano vector for tumor targeted gene therapy.
Source: Journal of Cancer Research and Clinical Oncology - July 1, 2023 Category: Cancer & Oncology Source Type: research

Simultaneous Delivery of Doxorubicin and EZH2 ‐Targeting siRNA by Vortex Magnetic Nanorods Synergistically Improved Anti‐Tumor Efficacy in Triple‐Negative Breast Cancer
A novel nanomedicine is synthesized based on Fe3O4 vortex nanorods loaded with doxorubicin (DOX) and EZH2 siRNAs and coated with a macrophage membrane. It shows a preferential tumor enrichment profile, thus leading to highly efficient drug delivery at the tumor site. Combining chemotherapy and gene therapy exhibits synergistic antitumor activity in a preclinical TNBC model. AbstractTriple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe3O4 vortex ...
Source: Small - June 28, 2023 Category: Nanotechnology Authors: Yunshu Lu, Fenfen Gu, Yuwei Ma, Ruonan Li, Yi Luo, Xianhong Da, Lan Jiang, Xiang Li, Yan Liu Tags: Research Article Source Type: research

Co-delivery of curcumin and si-STAT3 with a bioinspired tumor homing for polydopamine nanoparticles for synergistic osteosarcoma therapy
ConclusionThis study revealed that CPDA/siSTAT3@SCM NPs can target drug delivery by biomimetic multifunctional nanoparticles to treat OS through chemo-gene combined therapy.
Source: Cancer Nanotechnology - June 20, 2023 Category: Cancer & Oncology Source Type: research

The application of nucleic acid nanomaterials in the treatment of mitochondrial dysfunction
Curr Drug Metab. 2023 Jun 14. doi: 10.2174/1389200224666230614115655. Online ahead of print.ABSTRACTMitochondrial dysfunction is considered highly related to the development and progression of diseases, including cancer, metabolism disturbance, and neurodegeneration. Traditional pharmacological approach for mitochondrial dysfunction treatment has off-target and dose-dependent side effects, which leads to the emergence of mitochondrial gene therapy by regulating coding or noncoding genes by using nucleic acid sequences such as oligonucleotides, peptide nucleic acids, rRNA, siRNA, etc. To avoid size heterogeneity and potenti...
Source: Current Drug Metabolism - June 15, 2023 Category: Drugs & Pharmacology Authors: Lan Yao Hai Qing Tao Zhang Source Type: research