E-258 Endovascular approach to drug delivery to the brain

ConclusionsCPA delivery of AAV9 resulted in increased transduction of the parietal and cingulate cortex, comparable to that observed with CM injections. These results provide preliminary evidence that CPA infusion of gene therapy, and potentially other therapies such as antisense oligonucleotides or siRNA medications, is safe and provides widespread distribution throughout the brain.Abstract E-258 Figure 1Disclosures A. Malek: 4; C; CereVasc. H. Benatti: None. V. Anagnostakou: None. E. Hall: None. C. Heilman: 4; C; CereVasc. B. Beneduce: 4; C; CereVasc. A. Leporati: None. R. King: None. M. Gounis: 1; C; Research support from the NIH, the United States – Israel Binational Science Foundation, Anaconda, ApicBio, Arsenal Medical, Axovant, Balt, Cerenovus, Ceretrieve, CereVasc LLC, Cook Medical, Galaxy Th. 2; C; Consultant on a fee-per-hour basis for Alembic LLC, Astrocyte Pharmaceuticals, BendIt Technologies, Cerenovus, Imperative Care, Jacob’s Institute, Medtronic Neurovascular, Mivi Neurosciences, phenox G. 4; C; Imperative Care, InNeuroCo, Galaxy Therapeutics, and Neurogami, and Synchron. H. Gray-Edwards: None.

Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Malek, A., Benatti, H., Anagnostakou, V., Hall, E., Heilman, C., Beneduce, B., Leporati, A., King, R., Gounis, M., Gray-Edwards, H. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research