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Total 160 results found since Jan 2013.

Attenuated Salmonella-delivered PD-1 siRNA enhances the antitumor effects of EZH2 inhibitors in colorectal cancer
This study suggests an emerging strategy based on a combination of EZH2 inhibitor and immunotherapy based on PD-1 inhibition.PMID:37708707 | DOI:10.1016/j.intimp.2023.110918
Source: International Immunopharmacology - September 14, 2023 Category: Allergy & Immunology Authors: Mengmeng Lv Sheng Guo Xinyu Zhang Yan Zou Qiang Chen Chongyi Zang Shuo Huang Yuhan Hu Yanling Wang Qianqing Wang Jiateng Zhong Source Type: research

AURKA inhibitor-induced PD-L1 upregulation impairs antitumor immune responses
DiscussionOur data demonstrated that MLN8237 improved the effect of immunology-related therapy on tumor cells by interacting with anti-PD-L1 antibody, which contributed to producing creative sparks for exploring the possible solutions to overcoming drug resistance to tumor targeted therapy.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research

Lipid-Polymer Hybrid Nanoparticles with Both PD-L1 Knockdown and Mild Photothermal Effect for Tumor Photothermal Immunotherapy
In this study, dopamine-modified polyethylenimine (PEI) was prepared to fabricate an IR780 and siPD-L1 codelivery lipid-polymer hybrid nanoparticle (lip@PSD-siP) for the photothermal immunotherapy of CRC. The modification of dopamine can significantly reduce the cytotoxicity of PEI. lip@PSD-siP can be effectively taken up by CT26 cells and successfully escaped from lysosomes after entering the cells for 4 h. After CT26 cells were transfected with lip@PSD-siP, the PD-L1 positive cell rate decreased by 82.4%, and its PD-L1 knockdown effect was significantly stronger than the positive control Lipo3000-siP. In vivo studies sho...
Source: Cancer Control - August 22, 2023 Category: Cancer & Oncology Authors: Di Chuan Rangrang Fan Bo Chen Yangmei Ren Min Mu Haifeng Chen Bingwen Zou Haohao Dong Aiping Tong Gang Guo Source Type: research

Ultrasound-Mediated PLGA-PEI Nanobubbles Carrying STAT6 SiRNA Enhances NSCLC Treatment via Repolarizing Tumor-associated Macrophages from M2 to M1 Phenotypes
CONCLUSION: UMND enhanced PLGA-PEI NBs-STAT6 siRNA to repolarize TAMs from the M2 to the M1 phenotype, thus treating NSCLC. These findings provide a promising therapeutic approach for enhancing NSCLC immunotherapy.PMID:37491853 | DOI:10.2174/1567201820666230724151545
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hong Shu Wenhao Lv Zhi-Jian Ren Hui Li Tiantian Dong Yao Zhang Fang Nie Source Type: research

Inhibition of FGFR3 upregulates MHC ‐I and PD‐L1 via TLR3/NF‐kB pathway in muscle‐invasive bladder cancer
ConclusionTogether, our results suggest that FGFR3 might involve in immunosuppression by inhibition of NF-kB pathway in BC. Considering that TLR3 agonists are currently approved for clinical treatment as immunoadjuvants, our study might provide more insights for improving the efficacy of immunotherapy in MIBC.
Source: Cancer Medicine - June 7, 2023 Category: Cancer & Oncology Authors: WenBo Wu, Lei Chen, GaoZhen Jia, QiLin Tang, BangMin Han, ShuJie Xia, Qi Jiang, HaiTao Liu Tags: RESEARCH ARTICLE Source Type: research

Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery
Biomaterials. 2023 May 15;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Online ahead of print.ABSTRACTTherapeutic nucleic acids (TNAs) comprise an alternative to conventional drugs for cancer therapy. Recently, stable nucleic acid lipid particles (SNALPs) have been explored to deliver TNA efficiently and safely both in vitro and in vivo. Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as to whether...
Source: Biomaterials - May 27, 2023 Category: Materials Science Authors: Yue Qin Adam A Walters Nadia Rouatbi Julie Tzu-Wen Wang Hend Mohamed Abdel-Bar Khuloud T Al-Jamal Source Type: research

Integrating machine learning and single-cell trajectories to analyze T-cell exhaustion to predict prognosis and immunotherapy in colon cancer patients
ConclusionIn this study, we systematically explored the T-cell exhaustion trajectory in COAD and developed a TES model to assess prognosis and provide guidelines for the treatment decision. This discovery gave rise to a fresh concept for novel therapeutic procedures for the clinical treatment of COAD.
Source: Frontiers in Immunology - May 3, 2023 Category: Allergy & Immunology Source Type: research

Comprehensive Analysis of NABP2 as a Prognostic Biomarker and Its Correlation with Immune Infiltration in Hepatocellular Carcinoma
CONCLUSION: Based on these findings, NABP2 appears to be a candidate biomarker for HCC prognosis and immunotherapy.PMID:37113629 | PMC:PMC10128078 | DOI:10.2147/JIR.S403370
Source: Cell Research - April 28, 2023 Category: Cytology Authors: Bowen Li Jinghang Liu Liangzhi Xu Qi Xu Zhaohui Liu Tiande Liu Source Type: research

IDO2-siRNA carried by Salmonella combined with nifuroxazide attenuates melanoma growth
CONCLUSION: In conclusion, IDO2-siRNA combined with nifuroxazide therapy could serve a significant role in the treatment of melanoma-bearing mice, enhance the tumor immunity and provide an experimental basis for identifying a novel combination method for the treatment of melanoma clinically.PMID:36999419 | DOI:10.2174/1874467217666230329102030
Source: Cancer Control - March 31, 2023 Category: Cancer & Oncology Authors: Tiesuo Zhao Mengmeng Guo Haoqi Chen Lin Zhou Jing Guo Shenzhen Liu Zizhong Wang Wenshuai Huang Qiang Zhang Jiateng Zhong Mingyong Wang Huijie Jia Yongxi Zhang Source Type: research

Cationic lipid-assisted nanoparticles for simultaneous delivery of CD47 siRNA and R848 to promote antitumor immune responses
Discussion: To our best knowledge, our study pioneered co-delivery system for hydrophilic siCD47 and hydrophobic R848. It can maximize break tumor immune escape caused by CD47 and simultaneously enhance antigen presentation by activating DCs for effector T cell killing while regulating the tumor microenvironment as expected. Not only does it conform to the reports of previous basic research, but also it can break the bottleneck of their clinical application hopefully. Collectively, our findings could lay the foundation for future therapeutic strategies of TNBC.
Source: Frontiers in Pharmacology - March 31, 2023 Category: Drugs & Pharmacology Source Type: research

T7 peptide-decorated exosome-based nanocarrier system for delivery of Galectin-9 siRNA to stimulate macrophage repolarization in glioblastoma
ConclusionOverall, T7-Exo/siGalectin-9 promotes macrophage repolarization and restricts the immunosuppression of GBM, thus providing novel insights into and drug delivery system of immunotherapy for GBM.Graphical abstract
Source: Journal of Neuro-Oncology - March 1, 2023 Category: Cancer & Oncology Source Type: research