Inhibition of FGFR3 upregulates MHC ‐I and PD‐L1 via TLR3/NF‐kB pathway in muscle‐invasive bladder cancer

ConclusionTogether, our results suggest that FGFR3 might involve in immunosuppression by inhibition of NF-kB pathway in BC. Considering that TLR3 agonists are currently approved for clinical treatment as immunoadjuvants, our study might provide more insights for improving the efficacy of immunotherapy in MIBC.

Source: Cancer Medicine - June 7, 2023 Category: Cancer & Oncology Authors: WenBo Wu, Lei Chen, GaoZhen Jia, QiLin Tang, BangMin Han, ShuJie Xia, Qi Jiang, HaiTao Liu Tags: RESEARCH ARTICLE Source Type: research