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Specialty: Cardiology

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Total 800 results found since Jan 2013.

Involvement of lncR-30245 in Myocardial Infarction–Induced Cardiac Fibrosis Through Peroxisome Proliferator-Activated Receptor-γ–Mediated Connective Tissue Growth Factor Signalling Pathway
ConclusionOur study indicates that the lncR-30245/PPAR-γ/CTGF pathway mediates MI-induced cardiac fibrosis and might be a therapeutic target for various cardiac diseases associated with fibrosis.RésuméContexteLes longs ARN non codants (lncRNA) se révèlent actuellement comme des médiateurs importants de la physiopathologie cardiaque. Le but de la présente étude est d’examiner les effets d’un lncRNA (lncR-30245) sur la fibrogenèse cardiaque et les mécanismes sous-jacents.MéthodologieUn infarctus du myocarde (IM) et le facteur de croissance transformant β1 (TGF-β1) ont été utilisés pour produire des phéno...
Source: Canadian Journal of Cardiology - March 30, 2019 Category: Cardiology Source Type: research

Endothelial Foxp1 Regulates Pathological Cardiac Remodeling Through TGF- β1-Endothelin-1 Signal Pathway.
CONCLUSIONS: EC-Foxp1 regulates the TGF-β1-ET-1 pathway to control pathological cardiac fibrosis and hypertrophy, resulting in cardiac dysfunction. Therefore, targeting the EC-Foxp1-TGF-β1-ET-1 pathway might provide a future novel therapy for heart failure. PMID: 31177814 [PubMed - as supplied by publisher]
Source: Circulation - June 9, 2019 Category: Cardiology Authors: Liu J, Zhuang T, Pi J, Chen X, Zhang Q, Li Y, Wang H, Shen Y, Tomlinson B, Chan P, Yu Z, Cheng Y, Zheng X, Reilly M, Morrisey E, Zhang L, Liu Z, Zhang Y Tags: Circulation Source Type: research

The Human- and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling.
CONCLUSIONS: Collectively, we demonstrate that SMILR is a critical mediator of vascular smooth muscle cell proliferation via direct regulation of mitotic progression. Our data further reveals a potential SMILR-targeting intervention to limit atherogenesis and adverse vascular remodeling. PMID: 31339449 [PubMed - as supplied by publisher]
Source: Circulation Research - July 23, 2019 Category: Cardiology Authors: Mahmoud AD, Ballantyne MD, Miscianinov V, Pinel K, Hung J, Scanlon JP, Iyinikkel J, Kaczynski J, Tavares AA, Bradshaw AC, Mills NL, Newby DE, Caporali A, Gould GW, George S, Ulitsky I, Sluimer JC, Rodor J, Baker AH Tags: Circ Res Source Type: research

Future role of proprotein convertase subtilisin/kexin type 9 inhibitors in preventive cardiology
Purpose of review The use of therapeutic monoclonal antibodies to target proprotein convertase subtilisin/kexin type 9 (PCSK9) represents a novel approach to the management of hypercholesteremia and prevention of atherosclerotic cardiovascular disease. We review the most recent literature relevant to PCSK9 inhibition with emphasis on how recent results and ongoing trials have and will continue to shape the use of this new therapeutic class in preventive cardiology. Recent findings PCSK9 inhibitors reduce plasma lipoprotein(a) concentrations but a mechanistic understanding remains elusive. Evaluation of evolocumab for ...
Source: Current Opinion in Cardiology - August 8, 2019 Category: Cardiology Tags: PREVENTION: Edited by Ron Blankstein Source Type: research

Xanthoangelol Prevents Ox-LDL–Induced Endothelial Cell Injury by Activating Nrf2/ARE Signaling
Conclusions: These data suggest that XAG cytoprotects against Ox-LDL–induced cell injury through activating Nrf2/ARE–mediated antioxidative stress. Cumulatively, these findings show that EX has the potential to prevent and treat AS.
Source: Journal of Cardiovascular Pharmacology - August 1, 2019 Category: Cardiology Tags: Original Article Source Type: research

Dysfunction of B-cell lymphoma 2/adenovirus E1B 19KD interacting protein 3 in decidua is involved in the pathogenesis of preeclampsia
Conclusion: This study indicates that BNIP3 is particularly important for decidualization and may contribute to both the occurrence and development of preeclampsia via mTOR/p70s6k/BCL-2 signaling pathways.
Source: Journal of Hypertension - August 31, 2019 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Histone methylation and demethylation are implicated in the transient and sustained activation of the interleukin-1 β gene in murine macrophages
AbstractMacrophages play a crucial role in the development of atherosclerosis. To explore the mechanism by which macrophages attain a proinflammatory phenotype for a sustained period, we stimulated macrophages with lipopolysaccharide (LPS) and interferon- γ (IFN-γ) and measured the interleukin-1β (IL-1β) expression. The IL-1β expression increased transiently, and its expression lasted for, at least, 1 week after the cessation of LPS and IFN-γ stimulation. At the promoter region of theIL-1 β gene, the demethylation of histone H3 lysine 27 (H3K27) was significantly induced for 1  week after transient stimulation wit...
Source: Heart and Vessels - July 15, 2020 Category: Cardiology Source Type: research

NOD2 induces VCAM-1 and ET-1 gene expression via NF- κB in human umbilical vein endothelial cells with muramyl dipeptide stimulation.
CONCLUSION: Collectively, we confirmed NOD2 aggravated VCAM‑1 and ET‑1 gene expression through NF-κB in HUVECs treated with MDP. PMID: 33245410 [PubMed - as supplied by publisher]
Source: Herz - November 29, 2020 Category: Cardiology Tags: Herz Source Type: research

A Critical Review of the Efficacy and Safety of Inclisiran
AbstractThe association between low-density cholesterol (LDL-C) and cardiovascular disease (CVD) is well-established, with an emphasis on lowering LDL-C levels to reduce cardiovascular events. Statin therapy has been the traditional treatment for LDL-C reduction, in addition to lifestyle modifications, but studies have shown that a substantial proportion of patients does not reach target LDL-C goals despite receiving maximally tolerated statin medications. Additionally, statin therapy is associated with a few shortcomings as many patients initiated on these medications discontinue treatment within 1 year because of lack of...
Source: American Journal of Cardiovascular Drugs - May 6, 2021 Category: Cardiology Source Type: research

Reconstituted HDL-apoE3 promotes endothelial cell migration through ID1 and its downstream kinases ERK1/2, AKT and p38 MAPK
CONCLUSIONS: rHDL-apoE3 significantly enhanced EC migration in vitro, predominantly via overexpression of ID1 and subsequent activation of MEK1/2 and PI3K, and their downstream targets ERK1/2, AKT and p38 MAPK, respectively and improved vascular permeability in vivo. These novel insights into the rHDL-apoE3 functions suggest a potential clinical use to promote re-endothelialization and retard development of atherosclerosis.PMID:34875308 | DOI:10.1016/j.metabol.2021.154954
Source: Atherosclerosis - December 7, 2021 Category: Cardiology Authors: Eftaxia-Konstantina Valanti Katerina Dalakoura-Karagkouni Panagiotis Fotakis Elizabeth Vafiadaki Christos S Mantzoros Angeliki Chroni Vassilis Zannis Dimitris Kardassis Despina Sanoudou Source Type: research

Sirtuin1 contributes to the overexpression of Giα proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats
Conclusion: In summary, our results demonstrate that Sirt1 is overexpressed in VSMC from SHR which through augmenting oxidative stress contributes to the enhanced expression of Giα proteins, cell cycle proteins and resultant hyperproliferation of VSMC.
Source: Journal of Hypertension - December 10, 2021 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

MEF2A Is the Trigger of Resveratrol Exerting Protection on Vascular Endothelial Cell
In conclusion, resveratrol enhances MEF2A expression, and the upregulation of MEF2A is required for the endothelial protective benefits of resveratrol in vitro via activating SIRT1. Our work has also explored the in vivo relevance of this signaling pathway in experimental models of atherosclerosis and lipid dysregulation, setting the stage for more comprehensive phenotyping in vivo and further defining the molecular mechanisms.PMID:35047575 | PMC:PMC8762055 | DOI:10.3389/fcvm.2021.775392
Source: Atherosclerosis - January 20, 2022 Category: Cardiology Authors: Benrong Liu Lihua Pang Yang Ji Lei Fang Chao Wei Tian Jing Chen Changnong Chen Yun Zhong Wen-Chao Ou Yujuan Xiong Shi Ming Liu Source Type: research

Inhibition of semaphorin-3a alleviates lipopolysaccharide-induced vascular injury
This study aims to investigate the effects of inhibition of Sema3A on lipopolysaccharide (LPS)-induced vascular injury in mice. The mice were randomized into three groups: control, LPS, and LPS + siRNA. Mice in the combined group were given siRNA through fast tail vein injection, then LPS was injected intraperitoneally 7 days later, finally the mice were euthanized 24 h later. Vascular function and structure were assessed by vascular injury biomarkers and relevant stainings. LPS-induced vascular dysfunction and pathological injury were substantially improved by inhibition of Sema3A. Western blot and quantitative real-time ...
Source: Atherosclerosis - February 21, 2022 Category: Cardiology Authors: Yang Fu Jian-Wei Liu Ji Wu Zu-Xiang Wu Juan Li Hui-Fang Ji Ning-Peng Liang Hong-Jin Zhang Ze-Qun Lai Yi-Fei Dong Source Type: research

Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization
CONCLUSIONS: The above observations clearly reveal that PLCβ3-mediated NFATc1 activation-dependent CDC6 expression plays a crucial role in VEGFA/oxygen-induced retinopathy-induced retinal neovascularization.PMID:35236105 | DOI:10.1161/ATVBAHA.121.317182
Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 3, 2022 Category: Cardiology Authors: Raj Kumar Gadiparthi N Rao Source Type: research