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Specialty: Cardiology

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Total 800 results found since Jan 2013.

Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques.
Conclusions: Hybrid PET/MR imaging with a 13nm DNP enables noninvasive assessment of inflammation in experimental atherosclerotic plaques and reports on therapeutic efficacy of anti-inflammatory therapy. PMID: 23300273 [PubMed - as supplied by publisher]
Source: Circulation Research - January 8, 2013 Category: Cardiology Authors: Majmudar MD, Yoo J, Keliher E, Truelove JJ, Iwamoto Y, Sena B, Dutta P, Borodovsky A, Fitzgerald K, Di Carli MF, Libby P, Anderson D, Swirski FK, Weissleder R, Nahrendorf M Tags: Circ Res Source Type: research

Dihydropyridine Ca2+ Channel Blockers Increase Cytosolic Ca2+ by Activating Ca2+-sensing Receptors in Pulmonary Arterial Smooth Muscle Cells.
Conclusions: The dihydropyridine derivatives increase [Ca(2+)](cyt) by potentiating the activity of CaSR in PASMC independently of their blocking (or activating) effect on Ca(2+) channels; therefore, it is possible that use the dihydropyridine Ca(2+) channel blockers (e.g., nifedipine) to treat IPAH patients with upregulated CaSR in PASMC may exacerbate pulmonary hypertension. PMID: 23300272 [PubMed - as supplied by publisher]
Source: Circulation Research - January 8, 2013 Category: Cardiology Authors: Yamamura A, Yamamura H, Guo Q, Zimnicka AM, Wang J, Ko EA, Smith KA, Pohl NM, Song S, Zeifman A, Makino A, Yuan JX Tags: Circ Res Source Type: research

Novel Role of Copper Transport Protein Antioxidant-1 in Neointimal Formation After Vascular Injury.
CONCLUSIONS: Atox1 is involved in neointimal formation after vascular injury through promoting VSMC migration and inflammatory cell recruitment in injured vessels. Thus, Atox1 is a potential therapeutic target for VSMC migration and inflammation-related vascular diseases. PMID: 23349186 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 24, 2013 Category: Cardiology Authors: Kohno T, Urao N, Ashino T, Sudhahar V, McKinney RD, Hamakubo T, Iwanari H, Ushio-Fukai M, Fukai T Tags: Arterioscler Thromb Vasc Biol Source Type: research

Induction of oxidative stress by oxidized LDL via meprin{alpha}-activated epidermal growth factor receptor in macrophages
Conclusion Meprinα promotes OxLDL-induced plaque formation and ROS release by transactivation of the EGFR, followed by activation of the PI3K/Rac1/p38 pathway.
Source: Cardiovascular Research - February 8, 2013 Category: Cardiology Authors: Gao, P., Wang, X.-m., Qian, D.-h., Qin, Z.-X., Jin, J., Xu, Q., Yuan, Q.-Y., Li, X.-J., Si, L.-Y. Tags: Vascular biology and angiogenesis Source Type: research

The Polarity Protein Scrib is Essential for Directed Endothelial Cell Migration.
Conclusions: Scrib is a novel regulator of integrin α5 turnover and sorting, which is required for oriented cell migration and sprouting angiogenesis. PMID: 23362312 [PubMed - as supplied by publisher]
Source: Circulation Research - January 29, 2013 Category: Cardiology Authors: Michaelis UR, Chavakis E, Kruse C, Jungblut B, Kaluza D, Wandzioch K, Manavski Y, Heide H, Santoni MJ, Potente M, Eble JA, Borg JP, Brandes RP Tags: Circ Res Source Type: research

A 28-kDa Splice Variant of NADPH Oxidase-4 Is Nuclear-Localized and Involved in Redox Signaling in Vascular Cells.
CONCLUSIONS: Nox4D is a nuclear-localized and functionally active splice variant of Nox4 that may have important pathophysiologic effects through modulation of nuclear signaling and DNA damage. PMID: 23393389 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - February 7, 2013 Category: Cardiology Authors: Anilkumar N, Jose GS, Sawyer I, Santos CX, Sand C, Brewer AC, Warren D, Shah AM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Cross-talk between TLR4-MyD88-NF-{kappa}B and SCAP-SREBP2 pathways mediates macrophage foam cell formation
This study was designed to investigate cross-talk between TLR4-MyD88-NF-B and SCAP-SREBP2 pathways in macrophage foam cell formation. phorbol 12-myristate 13-acetate-activated THP-1 macrophages were transfected with negative control or MyD88 small interfering (si)RNA. Transfected cells were incubated with LPS in the absence or presence of LDL or IB kinase (IKK) inhibitor (BMS-345541). Intracellular cholesterol content was assessed. mRNA and protein expression of LDLR, HMG-CoAR, SCAP, and SREBP2 were examined by real-time RT-PCR and Western blot analysis. Intracellular translocation of SCAP in the organelles was detected by...
Source: AJP: Heart and Circulatory Physiology - March 15, 2013 Category: Cardiology Authors: Li, L.-C., Varghese, Z., Moorhead, J. F., Lee, C.-T., Chen, J.-B., Ruan, X. Z. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy
Conclusion These findings are consistent with a model in which oxidative damage of the RyR2 targets it for turnover by presenilins and CMA, which could lead to removal of damaged or leaky RyR2 channels.
Source: Cardiovascular Research - April 23, 2013 Category: Cardiology Authors: Pedrozo, Z., Torrealba, N., Fernandez, C., Gatica, D., Toro, B., Quiroga, C., Rodriguez, A. E., Sanchez, G., Gillette, T. G., Hill, J. A., Donoso, P., Lavandero, S. Tags: ORIGINAL ARTICLES: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE Source Type: research

Novel Long Non-Coding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells.
Conclusions: These data provide novel insights into the epigenomic and transcriptomic effects of Ang II in VSMCs. They provide the first identification of Ang II-regulated lncRNAs, which suggests functional roles for these lncRNAs in mediating cellular responses to Ang II. Furthermore, we identify one Ang II-regulated lncRNA that is responsible for the production of two miRNAs implicated in VSMC proliferation. These newly identified non-coding transcripts could be exploited as novel therapeutic targets for Ang II-associated cardiovascular diseases. PMID: 23697773 [PubMed - as supplied by publisher]
Source: Circulation Research - May 22, 2013 Category: Cardiology Authors: Leung A, Trac C, Jin W, Lanting L, Akbany A, Sætrom P, Schones DE, Natarajan R Tags: Circ Res Source Type: research

Prelamin a accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.
Conclusions: Prelamin A promotes VSMC calcification and aging by inducing persistent DNA damage signaling, which acts upstream of VSMC osteogenic differentiation and the senescence-associated secretory phenotype. Agents that target the DNA damage response and prelamin A toxicity may be potential therapies for the treatment of vascular calcification. PMID: 23564641 [PubMed - in process]
Source: Circulation Research - May 10, 2013 Category: Cardiology Authors: Liu Y, Drozdov I, Shroff R, Beltran LE, Shanahan CM Tags: Circ Res Source Type: research

Androgen Receptor Promotes Gender-Independent Angiogenesis in Response to Ischemia and is Required for Activation of VEGF Receptor Signaling.
CONCLUSIONS: These results document a physiological role of AR in gender-independent angiogenic potency and provide evidence for a novel cross-talk between androgen/AR signaling and VEGF/KDR signaling pathways. PMID: 23723256 [PubMed - as supplied by publisher]
Source: Circulation - May 30, 2013 Category: Cardiology Authors: Yoshida S, Aihara KI, Ikeda Y, Sumitomo-Ueda Y, Uemoto R, Ishikawa K, Ise T, Yagi S, Iwase T, Mouri Y, Sakari M, Matsumoto T, Takeyama KI, Akaike M, Matsumoto M, Sata M, Walsh K, Kato S, Matsumoto T Tags: Circulation Source Type: research

Tertiary-Butylhydroquinone Upregulates Expression of ATP-Binding Cassette Transporter A1 via Nuclear Factor E2-Related Factor 2/Heme Oxygenase-1 Signaling in THP-1 Macrophage-Derived Foam Cells.
Conclusions: Nrf2/HO-1 signaling is required for the regulation by tBHQ of ABCA1 expression and cholesterol efflux in macrophage-derived foam cells and an antiatherogenic role of tBHQ is suggested. PMID: 23739547 [PubMed - as supplied by publisher]
Source: Circulation Journal - June 5, 2013 Category: Cardiology Authors: Lu Q, Tang SL, Liu XY, Zhao GJ, Ouyang XP, Lv YC, He PP, Yao F, Chen WJ, Tang YY, Zhang M, Zhang DW, Yin K, Tang CK Tags: Circ J Source Type: research

Increase in cardiac M2-muscarinic receptor expression is regulated by GATA binding protein 4 (GATA-4) in streptozotocin-induced diabetic rats
Conclusions: We suggest that hyperglycemia can cause a higher expression of M2-mAChR in cardiomyocytes mainly through ROS to enhance MEK/ERK for phosphorylation of GATA-4.
Source: International Journal of Cardiology - February 1, 2012 Category: Cardiology Authors: Guang-Yuan Mar, Po-Ming Ku, Li-Jen Chen, Kai-Chun Cheng, Yin-Xiao Li, Juei-Tang Cheng Tags: Original Articles Source Type: research

HMGCoA reductase inhibition reverses myocardial fibrosis and diastolic dysfunction through AMP-activated protein kinase activation in a mouse model of metabolic syndrome
Conclusion In this model of MS, statin treatment reverses myocardial remodelling and improves ventricular relaxation through AMPK-mediated anti-fibrotic effects.
Source: Cardiovascular Research - June 20, 2013 Category: Cardiology Authors: Hermida, N., Markl, A., Hamelet, J., Van Assche, T., Vanderper, A., Herijgers, P., van Bilsen, M., Hilfiker-Kleiner, D., Noppe, G., Beauloye, C., Horman, S., Balligand, J.-L. Tags: Cardiac biology and remodelling Source Type: research

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury
Conclusion These results demonstrate that nuclear receptor FXR acts as a novel functional receptor in cardiac tissue, regulates apoptosis in cardiomyocytes, and contributes to MI/R injury.
Source: European Heart Journal - June 21, 2013 Category: Cardiology Authors: Pu, J., Yuan, A., Shan, P., Gao, E., Wang, X., Wang, Y., Lau, W. B., Koch, W., Ma, X.-L., He, B. Tags: BASIC SCIENCE Source Type: research