Prelamin a accelerates vascular calcification via activation of the DNA damage response and senescence-associated secretory phenotype in vascular smooth muscle cells.

Conclusions: Prelamin A promotes VSMC calcification and aging by inducing persistent DNA damage signaling, which acts upstream of VSMC osteogenic differentiation and the senescence-associated secretory phenotype. Agents that target the DNA damage response and prelamin A toxicity may be potential therapies for the treatment of vascular calcification.
PMID: 23564641 [PubMed - in process]

Source: Circulation Research - May 10, 2013 Category: Cardiology Authors: Liu Y, Drozdov I, Shroff R, Beltran LE, Shanahan CM Tags: Circ Res Source Type: research