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Total 101 results found since Jan 2013.
Circulating “LncPPARδ” From Monocytes as a Novel Biomarker for Coronary Artery Diseases
Abstract: To investigate long noncoding RNA NONHSAT112178 (LncPPARδ) as a biomarker for coronary artery disease (CAD) in peripheral blood monocyte cells, RT-qPCR was performed to validate the microarray results, receiver operating characteristic curve was applied to study the potential of LncPPARδ as a biomarker. Diagnostic models from LncPPARδ alone or combination of risk factors were constructed by Fisher criteria. The expression of genes neighboring the LncPPARδ gene was examined with RT-qPCR in THP-1 cell line treated with LncPPARδ siRNA. Using a diagnostic model by Fisher criteria, the consideration of risk facto...
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research
Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma
Conclusions:
These preclinical studies suggest that targeting p53 through PLK-1 is an attractive chemotherapy strategy warranting further investigation in adrenocortical cancer.
Source: Clinical and Translational Medicine - January 11, 2016 Category: Internal Medicine Authors: Kimberly BusseyAditi BapatClaire LinnehanMelissa WandoloskiErica DastrupErik RogersPaul GonzalesMichael Demeure Source Type: research
Membrane Trafficking of Collecting Duct Water Channel Protein AQP2 Regulated by Akt/AS160.
In this study, we demonstrated that 1) small interfering RNA (siRNA)-mediated gene silencing of Akt1 significantly decreased Akt1 and phospho-AS160 protein expression; and 2) confocal laser scanning microscopy of AQP2 in mouse cortical collecting duct cells (M-1 cells) revealed AS160 knockdown by siRNA increased AQP2 expression in the plasma membrane compared with controls, despite the absence of dDAVP stimulation. Thus, the results suggest that PI3K/Akt pathways could play a role in AQP2 trafficking via the AS160 protein.
PMID: 21468198 [PubMed]
Source: Electrolyte and Blood Pressure - December 11, 2015 Category: Internal Medicine Tags: Electrolyte Blood Press Source Type: research
CONSORT: Sam68 Is Directly Regulated by MiR-204 and Promotes the Self-Renewal Potential of Breast Cancer Cells by Activating the Wnt/Beta-Catenin Signaling Pathway
Abstract: Breast cancer stem cells (BCSCs) are considered to be responsible for recurrence in breast cancer. The 68 kDa Src-associated protein in mitosis (Sam68) has been linked to the development and progression of breast cancer; however, the posttranscriptional regulation and role of Sam68 in BCSC self-renewal remain unclear.
Sam68 was ectopically overexpressed or knocked down using a siRNA; the self-renewal potential of breast cancer cell lines was assessed using flow cytometry, in vitro mammosphere culture and a xenograft model in NOD/SCID mice. Activation of beta-catenin was assessed by immunohistochemical staining,...
Source: Medicine - December 1, 2015 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Theranostical nanosystem‐mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma
In conclusion, the theranostic siRNA nanomedicine examined here possesses great theranostic potential for combined gene therapy and MRI diagnosis of HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 1, 2015 Category: Internal Medicine Authors: Yu Guo, Jing Wang, Lu Zhang, Shunli Shen, Ruomi Guo, Yang Yang, Wenjie Chen, Yiru Wang, Guihua Chen, Xintao Shuai Tags: Hepatobiliary Malignancies Source Type: research
Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis
Although much progress has been made in identifying the mechanisms that trigger endothelial activation and inflammatory cell recruitment during atherosclerosis, less is known about the intrinsic pathways that counteract these events. Here we identified NOTCH1 as an antagonist of endothelial cell (EC) activation. NOTCH1 was constitutively expressed by adult arterial endothelium, but levels were significantly reduced by high-fat diet. Furthermore, treatment of human aortic ECs (HAECs) with inflammatory lipids (oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine [Ox-PAPC]) and proinflammatory cytokines (TNF and IL...
Source: The Journal of Experimental Medicine - November 16, 2015 Category: Internal Medicine Authors: Briot, A., Civelek, M., Seki, A., Hoi, K., Mack, J. J., Lee, S. D., Kim, J., Hong, C., Yu, J., Fishbein, G. A., Vakili, L., Fogelman, A. M., Fishbein, M. C., Lusis, A. J., Tontonoz, P., Navab, M., Berliner, J. A., Iruela-Arispe, M. L. Tags: Articles Source Type: research
Protecting liver sinusoidal endothelial cells suppresses apoptosis in acute liver damage
ConclusionHepatocyte apoptosis was reduced by the efficient suppression of LSEC apoptosis with a novel DDS. Protecting the sinusoidal structure by suppressing LSEC damage will be an effective treatment for acute liver failure. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - October 22, 2015 Category: Internal Medicine Authors: Tomohito Tanoi, Takafumi Tamura, Naoki Sano, Ken Nakayama, Kiyoshi Fukunaga, Yun‐Wen Zheng, Afsana Akhter, Yu. Sakurai, Yasuhiro Hayashi, Hideyoshi Harashima, Nobuhiro Ohkohchi Tags: Original Article Source Type: research
Regulation of mechanosensitive biliary epithelial transport by the Epithelial Na+ Channel, ENaC
In conclusion, our studies represent the initial characterization of mechanosensitive Na+ currents activated by flow in biliary epithelium. Understanding the role of mechanosensitive transport pathways may provide strategies to modulate the volume and composition of bile during cholestatic conditions. This article is protected by copyright. All rights reserved.
Source: Hepatology - October 17, 2015 Category: Internal Medicine Authors: Qin Li, Charles Kresge, Abhijit Bugde, Michelle Lamphere, Jason Y. Park, Andrew P. Feranchak Tags: Liver Biology and Pathobiology Source Type: research
Glucagon‐like peptide‐1 preserves non‐alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress‐associated pathway
ConclusionGLP‐1 protected against NAFLD by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46.
Source: Hepatology Research - August 18, 2015 Category: Internal Medicine Authors: Na Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research
Fibroblast growth factor receptor 3 isoforms: novel therapeutic targets for hepatocellular carcinoma?
Conclusions. Deregulated FGFR3 variants exhibit specific effects in the malignant progression of HCC cells. Accordingly, blockade of FGFR3‐mediated signaling may be a promising therapeutic approach to antagonize growth and malignant behavior of HCC cells. This article is protected by copyright. All rights reserved.
Source: Hepatology - August 1, 2015 Category: Internal Medicine Authors: Jakob Paur, Lisa Nika, Christiane Maier, Alexander Moscu‐Gregor, Julia Kostka, Daniela Huber, Thomas Mohr, Petra Heffeter, Waltraud C. Schrottmaier, Sonja Kappel, Daniela Kandioler, Klaus Holzmann, Brigitte Marian, Walter Berger, Michael Grusch, Bettina Tags: Hepatobiliary Malignancies Source Type: research
Glucagon‐like peptide‐1 (GLP‐1) preserves non‐alcoholic fatty liver disease (NAFLD) through inhibition of the endoplasmic reticulum (ER) stress‐associated pathway
ConclusionGLP‐1 protected against non‐alcoholic fatty liver disease by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - July 4, 2015 Category: Internal Medicine Authors: Na. Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research
Specific hepatic delivery of procollagen α1(I) siRNA in lipid‐like nanoparticles resolves liver fibrosis
Conclusion: The data reported in the present study extensively show that LNP‐siCol1a1 specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 10, 2015 Category: Internal Medicine Authors: Carolina Jiménez Calvente, Alfica Sehgal, Yury Popov, Yong Ook Kim, Victor Zevallos, Ugur Sahin, Mustafa Diken, Detlef Schuppan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research
Mineralocorticoid receptor suppresses cancer progression and Warburg effect by modulating miR‐338‐3p‐PKLR axis in hepatocellular carcinoma
Conclusion: The present study reveals a novel role of MR in HCC development by modulating miR‐338‐3p‐PKLR axis with an ability to suppress the Warburg effect. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 1, 2015 Category: Internal Medicine Authors: Huizhen Nie, Jun Li, Xiao‐Mei Yang, Qing‐Zhen Cao, Ming‐Xuan Feng, Feng Xue, Lin Wei, Wenxin Qin, Jianren Gu, Qiang Xia, Zhi‐Gang Zhang Tags: Hepatobiliary Malignancies Source Type: research
Trefoil Factor 3 as a Novel Biomarker to Distinguish Between Adenocarcinoma and Squamous Cell Carcinoma
In conclusion, TFF3 is preferentially expressed in adenocarcinoma and may function as an additional biomarker for distinguishing adenocarcinoma from squamous cell carcinoma.
Source: Medicine - May 1, 2015 Category: Internal Medicine Tags: Article: Observational Study Source Type: research
Activation of Sphingosine Kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance
Conclusion: Sphk2 is transcriptionally upregulated by acute ER stress via activation of ATF4 and improves perturbed hepatic glucose and fatty acid metabolism. This article is protected by copyright. All rights reserved.
Source: Hepatology - March 22, 2015 Category: Internal Medicine Authors: Su‐Yeon Lee, In‐Kyung Hong, Bo‐Rahm Kim, Soon‐Mi Shim, Jae Sung Lee, Hui‐Young Lee, Cheol Soo Choi, Bo‐Kyung Kim, Tae‐Sik Park Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
