Fibroblast growth factor receptor 3 isoforms: novel therapeutic targets for hepatocellular carcinoma?

Conclusions. Deregulated FGFR3 variants exhibit specific effects in the malignant progression of HCC cells. Accordingly, blockade of FGFR3‐mediated signaling may be a promising therapeutic approach to antagonize growth and malignant behavior of HCC cells. This article is protected by copyright. All rights reserved.

Source: Hepatology - August 1, 2015 Category: Internal Medicine Authors: Jakob Paur, Lisa Nika, Christiane Maier, Alexander Moscu‐Gregor, Julia Kostka, Daniela Huber, Thomas Mohr, Petra Heffeter, Waltraud C. Schrottmaier, Sonja Kappel, Daniela Kandioler, Klaus Holzmann, Brigitte Marian, Walter Berger, Michael Grusch, Bettina Tags: Hepatobiliary Malignancies Source Type: research