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Total 101 results found since Jan 2013.
Increased duodenal iron absorption through upregulation of DMT1 due to enhancement of IRP1 activity in patients with NASH
Conclusion: In spite of elevation of serum hepcidin, iron absorption from the gastrointestinal tract increased through upregulation of DMT1, via IRP1 activation by humoral factor(s) in the sera of patients with NASH. This article is protected by copyright. All rights reserved.
Source: Hepatology - March 7, 2015 Category: Internal Medicine Authors: Toshifumi Hoki, Koji Miyanishi, Shingo Tanaka, Kohichi Takada, Yutaka Kawano, Akira Sakurada, Masanori Sato, Tomohiro Kubo, Tsutomu Sato, Yasushi Sato, Rishu Takimoto, Masayoshi Kobune, Junji Kato Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
MiR‐486 regulates metastasis and chemosensitivity in hepatocellular carcinoma by targeting CLDN10 and CITRON
ConclusionsOur data indicated that miR‐486 may function as a novel tumor suppressor in HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - February 5, 2015 Category: Internal Medicine Authors: Huiyan Sun, Chunping Cui, Fengjun Xiao, Hua Wang, Jun Xu, Xuefeng Shi, Yuefeng Yang, Qunwei Zhang, Xiaofei Zheng, Xiaoming Yang, Chutse Wu, Lisheng Wang Tags: Original Article Source Type: research
Liver X receptors balance lipid stores in hepatic stellate cells via Rab18, a retinoid responsive lipid droplet protein
Conclusion: Retinoid and cholesterol metabolism are linked in stellate cells by the LD associated protein, Rab18. Retinoid overload helps explain the pro‐fibrotic phenotype of Lxrαβ‐/‐ mice and we establish a pivotal role for Rab18 GTPase activity and membrane insertion in wild‐type stellate cell activation. Interference with Rab18 may have significant therapeutic benefit in ameliorating liver fibrosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 6, 2014 Category: Internal Medicine Authors: Fiona O'Mahony, Kevin Wroblewski, Sheila M. O'Byrne, Hongfeng Jiang, Kara Clerkin, Jihane Benhammou, William S. Blaner, Simon W. Beaven Tags: Liver Biology and Pathobiology Source Type: research
Role of transcription factor CCAAT/enhancer‐binding protein alpha in human fetal liver cell types in vitro
ConclusionWe demonstrated that the effects of C/EBPα are specific for the different human fetal liver cell types, using an advanced 3‐D perfusion bioreactor as a human in vivo‐like model.
Source: Hepatology Research - October 9, 2014 Category: Internal Medicine Authors: Jörg C. Gerlach, Patrick Over, Hubert G. Foka, Morris E. Turner, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: Original Article Source Type: research
Shp/Npas2 axis in regulating the oscillation of liver lipid metabolism
Conclusion: Shp and Npas2 crosstalk is essential to maintain hepatic lipid homeostasis. (Hepatology 2014)
Source: Hepatology - September 12, 2014 Category: Internal Medicine Authors: Sang Min Lee, Yuxia Zhang, Hiroyuki Tsuchiya, Rana Smalling, Anton M. Jetten, Li Wang Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Role ofTranscription Factor CCAAT/Enhancer Binding Protein Alphain Human Fetal LiverCell Typesin vitro
ConclusionsWe demonstrated that the effects of C/EBPα are specific for the different human fetal liver cell types, using an advanced three‐dimensional perfusion bioreactor as a humanin vivo‐like model.
Source: Hepatology Research - September 5, 2014 Category: Internal Medicine Authors: Jörg C. Gerlach, Patrick Over, Hubert G. Foka, Morris E. Turner, Robert L. Thompson, Bruno Gridelli, Eva Schmelzer Tags: Original Article Source Type: research
Livin is associated with the invasive and oncogenic phenotypes of human hepatocellular carcinoma cells
ConclusionThese results suggest that Livin is associated with invasive and oncogenic phenotypes of human HCC cells.
Source: Hepatology Research - July 22, 2014 Category: Internal Medicine Authors: Sung‐Bum Cho, Wan‐Sik Lee, Young‐Lan Park, Nuri Kim, Hyung‐Hoon Oh, Mi‐Young Kim, Chan‐Young Oak, Cho‐Yun Chung, Hyung‐Chul Park, Jong‐Sun Kim, Dae‐Seong Myung, Sang‐Hoon Kim, Kyung‐Hwa Lee, Sung‐Kyu Choi, Young‐Eun Joo Tags: Original Article Source Type: research
Activation of the developmental pathway Neurogenin‐3/microRNA‐7a regulates cholangiocyte proliferation in response to injury
ABSTRACT
Background/aims: The activation of the biliary stem‐cell signalling pathway Hes‐1/PDX‐1 in mature cholangiocytes determines cell proliferation. Neurogenin‐3 (Ngn‐3) is required for pancreas development and ductal cell neogenesis. PDX‐1‐dependent activation of Ngn‐3 initiates the differentiation program, by inducting microRNA (miR)‐7 expression. Here, we investigated the role Ngn‐3 on cholangiocyte proliferation. Methods: Expression levels of Ngn‐3 and miR‐7 isoforms were tested in cholangiocytes from normal and cholestatic human livers. Ngn‐3 was knocked‐down in vitro in normal rat chol...
Source: Hepatology - June 13, 2014 Category: Internal Medicine Authors: Marco Marzioni, Laura Agostinelli, Cinzia Candelaresi, Stefania Saccomanno, Samuele De Minicis, Luca Maroni, Eleonora Mingarelli, Chiara Rychlicki, Luciano Trozzi, Jesus M. Banales, Antonio Benedetti, Gianluca Svegliati Baroni Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Perturbation of specific pro-mineralizing signalling pathways in human and murine pseudoxanthoma elasticum
Conclusions:
Our study shows that we cannot simply extrapolate knowledge on cell signalling in vascular soft tissue calcification to a multisystem ectopic mineralisation disease as PXE. Contrary, we demonstrate a specific set of perturbed signalling pathways in PXE patients and the knock-out mouse model. Based on our findings and previously reported data, we propose a preliminary cell model of ECM calcification in PXE.
Source: Orphanet Journal of Rare Diseases - April 29, 2014 Category: Internal Medicine Authors: Mohammad HosenPaul CouckeOlivier Le SauxAnne De PaepeOlivier Vanakker Source Type: research
RNA interference against cancer/testis genes identifies dual specificity phosphatase 21 as a potential therapeutic target in human hepatocellular carcinoma
Conclusion: DUSP21 plays an important role in sustaining HCC cell proliferation and may thus act as a potential therapeutic target in HCC treatment. (Hepatology 2013;)
Source: Hepatology - December 18, 2013 Category: Internal Medicine Authors: Qing Deng, Kun‐Yu Li, Hui Chen, Ji‐Hong Dai, Yang‐Yang Zhai, Qun Wang, Niu Li, Yu‐Ping Wang, Ze‐Guang Han Tags: Hepatobiliary Malignancies Source Type: research
Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR{gamma} activation
Tumor metastasis and lack of NKG2D ligand (NKG2DL) expression are associated with poor prognosis in patients with colon cancer. Here, we found that spironolactone (SPIR), an FDA-approved diuretic drug with a long-term safety profile, can up-regulate NKG2DL expression in multiple colon cancer cell lines by activating the ATM–Chk2-mediated checkpoint pathway, which in turn enhances tumor elimination by natural killer cells. SPIR can also up-regulate the expression of metastasis-suppressor genes TIMP2 and TIMP3, thereby reducing tumor cell invasiveness. Although SPIR is an aldosterone antagonist, its antitumor effects a...
Source: The Journal of Experimental Medicine - November 18, 2013 Category: Internal Medicine Authors: Leung, W.-H., Vong, Q. P., Lin, W., Janke, L., Chen, T., Leung, W. Tags: Articles Source Type: research
Signal transducer and activator of transcription 3 is a proviral host factor for hepatitis C virus
Conclusion: We have demonstrated that STAT3 plays a role in the life cycle of HCV and have clarified the role of STAT3 as a proviral host factor. (HEPATOLOGY 2013)
Source: Hepatology - October 1, 2013 Category: Internal Medicine Authors: Erin M. McCartney, Karla J. Helbig, Sumudu K. Narayana, Nicholas S. Eyre, Amanda L. Aloia, Michael R. Beard Tags: Viral Hepatitis Source Type: research
Protein kinase a‐dependent pSer675‐β‐catenin, a novel signaling defect in a mouse model of congenital hepatic fibrosis
Conclusion: These data show that in fibrocystin‐defective cholangiocytes, cAMP/PKA signaling stimulates pSer675‐phosphorylation of β‐catenin and Rac‐1 activity. In the presence of activated Rac‐1, pSer675‐β‐catenin is translocated to the nucleus, becomes transcriptionally active, and is responsible for increased motility of Pkhd1del4/del4 cholangiocytes. β‐Catenin‐dependent changes in cell motility may be central to the pathogenesis of the disease and represent a potential therapeutic target. (Hepatology 2013)
Source: Hepatology - September 30, 2013 Category: Internal Medicine Authors: Carlo Spirli, Luigi Locatelli, Carola M. Morell, Romina Fiorotto, Stuart D. Morton, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Gankyrin promotes tumor growth and metastasis through activation of IL‐6/STAT3 signaling in human cholangiocarcinoma
Conclusion: Gankyrin is crucial for CCA carcinogenesis and metastasis by activating IL‐6/STAT3 signaling pathway through downregulating Rb protein. (Hepatology 2013;)
Source: Hepatology - August 26, 2013 Category: Internal Medicine Authors: Tongsen Zheng, Xuehui Hong, Jiabei Wang, Tiemin Pei, Yingjian Liang, Dalong Yin, Ruipeng Song, Xuan Song, Zhaoyang Lu, Shuyi Qi, Jiaren Liu, Boshi Sun, Changming Xie, Shangha Pan, Yuejin Li, Xiaohe Luo, Shuai Li, Xiang Fang, Nishant Bhatta, Hongchi Jiang, Tags: Hepatobiliary Malignancies Source Type: research
RNA interference against cancer/testis genes identifies DUSP21 as a potential therapeutic target in human hepatocellular carcinoma
Conclusion: DUSP21 plays an important role in sustaining HCC cell proliferation and may thus act as a potential therapeutic target in HCC treatment. (Hepatology 2013;)
Source: Hepatology - August 8, 2013 Category: Internal Medicine Authors: Qing Deng, Kun‐Yu Li, Hui Chen, Ji‐Hong Dai, Yang‐Yang Zhai, Qun Wang, Niu Li, Yu‐Ping Wang, Ze‐Guang Han Tags: Hepatobiliary Malignancies Source Type: research
