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Specialty: Internal Medicine
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Total 101 results found since Jan 2013.
Bile acids stimulate cholangiocyte fluid secretion by activation of membraneTMEM16A Cl ‐ channels
Conclusion: Bile acids stimulate Cl‐ secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca2+]i. These studies suggest that TMEM16A channels may be targets to increase bile flow during cholestasis. This article is protected by copyright. All rights reserved.
Source: Hepatology - January 23, 2018 Category: Internal Medicine Authors: Qin Li, Amal Dutta, Charles Kresge, Abhijit Bugde, Andrew P. Feranchak Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Long noncoding RNA hypoxia-inducible factor 1 alpha-antisense RNA 1 promotes tumor necrosis factor-α-induced apoptosis through caspase 3 in Kupffer cells
This study elucidates a new role of HIF1A-AS1 in TNF-α-induced cell apoptosis and provides potential therapeutic targets for ACLF.
Source: Medicine - January 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome
We describe a fatal case of pediatric systemic capillary leak (Clarkson’s disease) associated with a point mutation in p190BRhoGAP. Dermal microvascular endothelial cells (ECs) isolated from this patient form monolayers with similar levels and distribution of junctional proteins and transendothelial electrical resistance compared with normal human dermal microvascular ECs. However, patient-derived ECs demonstrate a greater increase in permeability and impaired recovery of barrier function in response to tumor necrosis factor (TNF) compared with normal donor EC cultures. TNF transiently activates RhoB in ECs coinciden...
Source: The Journal of Experimental Medicine - November 29, 2017 Category: Internal Medicine Authors: Pierce, R. W., Merola, J., Lavik, J. P., Kluger, M. S., Huttner, A., Khokha, M. K., Pober, J. S. Tags: Cardiovascular Biology, Innate Immunity and Inflammation, Human Disease Genetics Brief Definitive Reports Source Type: research
Polo ‐like‐kinase 1 is a proviral host factor for hepatitis B virus replication
Conclusion: PLK1 is a proviral host factor that could be envisaged as a target for combined antiviral and antitumoral strategies against HBV infection and HBV‐mediated carcinogenesis. (Hepatology 2017).
Source: Hepatology - November 6, 2017 Category: Internal Medicine Authors: Ahmed Diab, Adrien Foca, Floriane Fusil, Thomas Lahlali, Pascal Jalaguier, Fouzia Amirache, Lia N'Guyen, Nathalie Isorce, Fran çois‐Loïc Cosset, Fabien Zoulim, Ourania Andrisani, David Durantel Tags: Viral Hepatitis Source Type: research
Cholangiocyte Autophagy Contributes to Hepatic Cystogenesis in Polycystic Liver Disease and Represents a Potential Therapeutic Target
Conclusion: Autophagy is increased in PLD cholangiocytes, contributes to hepatic cystogenesis, and represents a potential therapeutic target for disease treatment. This article is protected by copyright. All rights reserved.
Source: Hepatology - October 10, 2017 Category: Internal Medicine Authors: Anatoliy I. Masyuk, Tatyana V. Masyuk, Maria J. Lorenzo Pisarello, Jingyi (Francess) Ding, Lorena Loarca, Bing Q. Huang, Nicholas F. LaRusso Tags: Liver Biology and Pathobiology Source Type: research
Effects of TRPC1 on epithelial mesenchymal transition in human airway in chronic obstructive pulmonary disease
Conclusion:
Overexpression of TRPC1 in COPD promoted EMT process and TRPC1 may be a new and interesting focus for COPD new treatment in the future.
Source: Medicine - October 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
BRCA2 protects mammalian cells from heat shock.
CONCLUSION: BRCA2 has a protecting role against heat-induced cell death. BRCA2 might be a potential molecular target for hyperthermic cancer therapy.
PMID: 28891354 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - September 13, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Targeting CCl4 ‐induced liver fibrosis by RNA interference–mediated inhibition of cyclin E1 in mice
Conclusion: Therapeutic targeting of CcnE1 in vivo using RNAi is feasible and has high antifibrotic activity. (Hepatology 2017).
Source: Hepatology - August 26, 2017 Category: Internal Medicine Authors: J örg‐Martin Bangen, Linda Hammerich, Roland Sonntag, Maike Baues, Ute Haas, Daniela Lambertz, Thomas Longerich, Twan Lammers, Frank Tacke, Christian Trautwein, Christian Liedtke Tags: Liver Injury and Regeneration Source Type: research
Targeting senescent cholangiocytes and activated fibroblasts with Bcl ‐xL inhibitors ameliorates fibrosis in Mdr2‐/‐ mice
Conclusions: Bcl‐xL is a key survival factor in ASF as well as in senescent cholangiocytes. Treatment with the Bcl‐xL‐specific inhibitor A‐1331852 reduces liver fibrosis, possibly by a dual effect on activated fibroblasts and senescent cholangiocytes. This novel mechanism represents an attractive therapeutic strategy in biliary fibrosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - August 12, 2017 Category: Internal Medicine Authors: Anja Moncsek, Mohammed S. Al ‐Suraih, Christy E. Trussoni, Steven P. O'Hara, Patrick L. Splinter, Camille Zuber, Eleonora Patsenker, Piero V. Valli, Christian D. Fingas, Achim Weber, Yi Zhu, Tamar Tchkonia, James L. Kirkland, Gregory J. Gores, Beat Mül Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research
Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
Conclusion: Our data indicate that SIRT3 is a negative regulator of autophagy whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. (Hepatology 2017).
Source: Hepatology - July 20, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma
Conclusion: We conclude that miR-107 is likely to inhibit the occurrence and development of OS by down-regulating Dkk-1 via the Wnt/β-catenin signaling pathway, providing us with a new therapeutic target for the treatment of OS.
Source: Medicine - July 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Role of thymic stromal lymphopoietin in the pathogenesis of lumbar disc degeneration
This study aims to investigate the role of thymic stromal lymphopoietin (TSLP) in the pathogenesis of lumbar disc degeneration (LDD).
Methods: Nucleus pulposus tissues were collected from 77 LDD patients (the case group), in addition, normal tissues were extracted from 21 patients suffering from lumbar fractures (the control group). Immunohistochemistry was applied in order to detect TSLP positive expression. In accordance with varying transfection, the cells were divided into TSLP-siRNA, TSLP-siRNA + TSLPR-siRNA, control, blank, anti-TSLPR, and IgG groups. Western blotting was used in order to detect TSLP expression ...
Source: Medicine - July 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Circular RNA MTO1 acts as the sponge of miR ‐9 to suppress hepatocellular carcinoma progression
Conclusion: circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR‐9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment. The decrease of circMTO1 in HCC tissues may serve as a prognosis predictor for poor survival of patients. This article is protected by copyright. All rights reserved.
Source: Hepatology - May 18, 2017 Category: Internal Medicine Authors: Dan Han, Jiangxue Li, Huamin Wang, Xiaoping Su, Jin Hou, Yan Gu, Cheng Qian, Yun Lin, Xiang Liu, Mingyan Huang, Nan Li, Weiping Zhou, Yizhi Yu, Xuetao Cao Tags: Hepatobiliary Malignancies Source Type: research
Targeting CCl4 ‐induced liver fibrosis by RNA interference ‐ mediated inhibition of Cyclin E1 in mice
Conclusion: Therapeutic targeting of CcnE1 in vivo using RNAi is feasible and has high anti‐fibrotic activity. This article is protected by copyright. All rights reserved.
Source: Hepatology - May 1, 2017 Category: Internal Medicine Authors: J örg‐Martin Bangen, Linda Hammerich, Roland Sonntag, Maike Baues, Ute Haas, Daniela Lambertz, Thomas Longerich, Twan Lammers, Frank Tacke, Christian Trautwein, Christian Liedtke Tags: Liver Injury and Regeneration Source Type: research
SIRT3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity
Conclusion: our data identified SIRT3 to be a novel negative regulator of autophagy, whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 24, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
