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Specialty: Internal Medicine
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Total 101 results found since Jan 2013.
A Novel Role of Astrocyte Elevated Gene ‐1 (AEG‐1) in Regulating Non‐alcoholic Steatohepatitis (NASH)
Conclusion: AEG‐1 might be a key molecule regulating initiation and progression of NASH. AEG‐1 inhibitory strategies might be developed as a potential therapeutic intervention in NASH patients. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 24, 2017 Category: Internal Medicine Authors: Jyoti Srivastava, Chadia L. Robertson, Kareem Ebeid, Mikhail Dozmorov, Devaraja Rajasekaran, Rachel Mendoza, Ayesha Siddiq, Maaged A. Akiel, Nidhi Jariwala, Xue ‐Ning Shen, Jolene J. Windle, Mark A. Subler, Nitai D. Mukhopadhyay, Shah Giashuddin, Shobha Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Efficient replication of blood borne Hepatitis C Virus in human fetal liver stem cells
Conclusion: Our data showed that the entire bbHCV life cycle could be naturally imitated in hFLSCs. This model is expected to provide a powerful tool for exploring the process and the mechanism of bbHCV infection at the cellular level, and evaluating the treatment and preventive strategies of bbHCV infection. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 13, 2017 Category: Internal Medicine Authors: Xuan Guo, Shu Wang, Zhi ‐Gang Qiu, Ya‐Ling Dou, Wei‐Li Liu, Dong Yang, Zhi‐Qiang Shen, Zhao‐Li Chen, Jing‐Feng Wang, Bin‐ Zhang, Xin‐Wei Wang, Xiang‐Fei Guo, Xue‐Lian Zhang, Min Jin, Jun‐Wen Li Tags: Viral Hepatitis Source Type: research
Targeting β‐catenin in hepatocellular cancers induced by co‐expression of mutant β‐catenin and K‐Ras in mice
In conclusion, we show that Ras activation downstream of c‐Met is sufficient to induce clinically relevant HCC in cooperation with mutant β‐catenin. β‐Catenin suppression by a clinically relevant modality is effective in treatment of β‐catenin‐positive, GS‐positive HCCs. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 15, 2016 Category: Internal Medicine Authors: Junyan Tao, Rong Zhang, Sucha Singh, Minakshi Poddar, Emily Xu, Michael Oertel, Xin Chen, Shanthi Ganesh, Marc Abrams, Satdarshan P. Monga Tags: Hepatobiliary Malignancies Source Type: research
The UPR mediates fibrogenesis and collagen I secretion through regulating TANGO1
Conclusion: Loss of TANGO1 leads to procollagen I retention in the ER which promotes UPR‐mediated HSC apoptosis. TANGO1 regulation during HSC activation occurs through a UPR dependent mechanism that requires the transcription factor XBP‐1. Finally, TANGO1 is critical for fibrogenesis through mediating HSC homeostasis. Our work reveals a unique role for TANGO1 and the UPR in facilitating collagen I secretion and fibrogenesis. This article is protected by copyright. All rights reserved.
Source: Hepatology - November 4, 2016 Category: Internal Medicine Authors: Jessica L Maiers, Enis Kostallari, Malek Mushref, Thiago M de Assuncao, Haiyang Li, Robert C Huebert, Sheng Cao, Harmeet Malhi, Vijay H Shah Tags: Liver Biology and Pathobiology Source Type: research
Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression
ConclusionsSignal transducer and activator of transcription 5 plays an important role in hepatic fat metabolism through regulation of CD36, and is a potential therapeutic candidate for liver steatosis.
Source: Hepatology Research - October 17, 2016 Category: Internal Medicine Authors: Atsushi Hosui, Tomohide Tatsumi, Hayato Hikita, Yoshinobu Saito, Naoki Hiramatsu, Masahiko Tsujii, Lothar Hennighausen, Tetsuo Takehara Tags: Original Article Source Type: research
Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer
This study supports the notion that inhibition of ADAM28 may be a potential novel therapeutic strategy for human prostate cancer.
Source: Medicine - October 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Hepatic Stellate Cells Induce HCC Cell Resistance to Sorafenib through the Laminin ‐332/α3 Integrin Axis recovery of FAK Ubiquitination
Conclusion. This study unveils a novel mechanism of sorafenib resistance depending on the α3β1/Ln‐332 axis and requiring FAK ubiquitination, providing new insights into personalizing therapy for patients with HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - September 16, 2016 Category: Internal Medicine Authors: Amalia Azzariti, Serena Mancarella, Letizia Porcelli, Anna Elisa Quatrale, Alessandra Caligiuri, Luigi Lupo, Francesco Dituri, Gianluigi Giannelli Tags: Hepatobiliary Malignancies Source Type: research
Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease
Conclusion: Rubicon is overexpressed and plays a pathogenic role in NAFLD by accelerating hepatocellular lipoapoptosis and lipid accumulation, as well as inhibiting autophagy. Rubicon may be a novel therapeutic target for regulating NAFLD development and progression. This article is protected by copyright. All rights reserved.
Source: Hepatology - September 15, 2016 Category: Internal Medicine Authors: Satoshi Tanaka, Hayato Hikita, Tomohide Tatsumi, Ryotaro Sakamori, Yasutoshi Nozaki, Sadatsugu Sakane, Yuto Shiode, Tasuku Nakabori, Yoshinobu Saito, Naoki Hiramatsu, Keisuke Tabata, Tsuyoshi Kawabata, Maho Hamasaki, Hidetoshi Eguchi, Hiroaki Nagano, Tamo Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
MicroRNA-9 regulates the development of knee osteoarthritis through the NF-kappaB1 pathway in chondrocytes
This study was aimed to investigate the association between the mechanism of miR-9 targeting nuclear factor kappa-B1 (NF-κB1) and the proliferation and apoptosis of knee OA chondrocytes.
Cartilage samples were collected from 25 patients with knee OA and 10 traumatic amputees, and another 15 OA rat models, together with 15 rats without knee OA lesions were also established. MiR-9 expressions in both knee OA cartilage and normal cartilage samples were detected using quantitative real-time PCR. The expressions of related genes (NF-κB1, IL-6, and MMP-13) in the two groups were also detected. Dual luciferase reporter gene as...
Source: Medicine - September 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
STAT5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression
CONCLUSIONS: STAT5 plays an important role in hepatic fat metabolism through regulation of CD36, and is a potential therapeutic candidate for liver steatosis.
Source: Hepatology Research - August 31, 2016 Category: Internal Medicine Authors: Atsushi Hosui, Tomohide Tatsumi, Hayato Hikita, Yoshinobu Saito, Naoki Hiramatsu, Masahiko Tsujii, Lothar Hennighausen, Tetsuo Takehara Tags: Original Article Source Type: research
The Myeloid HSF1 ‐Β‐Catenin Axis Regulates NLRP3 Inflammasome Activation in Mouse Liver Ischemia/Reperfusion Injury
Conclusions: The myeloid HSF1‐β‐catenin axis controlled NLRP3 activation by modulating the XBP1 signaling pathway. HSF1 activation promoted β‐catenin, which in turn inhibited XBP1, leading to NLRP3 inactivation and reduced IR‐induced liver injury. Our findings demonstrated that HSF1‐β‐catenin signaling is a novel regulator of innate immunity in liver inflammatory injury and implied the therapeutic potential for the management of sterile liver inflammation in transplant recipients. This article is protected by copyright. All rights reserved.
Source: Hepatology - July 29, 2016 Category: Internal Medicine Authors: Shi Yue, Jianjun Zhu, Ming Zhang, Changyong Li, Xingliang Zhou, Min Zhou, Michael Ke, Ronald W. Busuttil, Qilong Ying, Jerzy W. Kupiec ‐Weglinski, Qiang Xia, Bibo Ke Tags: Liver Injury and Regeneration Source Type: research
Receptor interacting protein 3 protects mice from high fat diet‐induced liver injury
Conclusion: Absence of RIP3, a key mediator of necroptosis, exacerbated HFD‐induced liver injury, associated with increased inflammation and hepatocyte apoptosis, as well as early fibrotic responses. These findings indicate that shifts in the mode of hepatocellular death can influence disease progression and have therapeutic implications because manipulation of hepatocyte cell death pathways is being considered as a target for treatment of NAFLD. This article is protected by copyright. All rights reserved.
Source: Hepatology - June 14, 2016 Category: Internal Medicine Authors: Sanjoy Roychowdhury, Rebecca L. McCullough, Carlos Sanz‐Garcia, Paramananda Saikia, Naim Alkhouri, Ammar Matloob, Katherine Pollard, Megan R. McMullen, Colleen M. Croniger, Laura E. Nagy Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons
Abstract: Tricyclic antidepressant amitriptyline (AM) has been shown to exert neurotrophic activity on neurons. We thus explored whether AM may aid the neuronal development and protect anesthesia-induced neuro-injury in young spinal cord dorsal root ganglion (DRG) neurons.
The DRG explants were prepared from 1-day-old rats. The effect of AM on aiding DRG neural development was examined by immunohistochemistry at dose-dependent manner. AM-induced changes in gene and protein expressions, and also phosphorylation states of tyrosine kinases receptor A (TrkA) and B (TrkB) in DRG, were examined by quantitative real-time polymer...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysisof Observ Studiesin Epidemiology Source Type: research
Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice
Conclusion: In conclusion, our results strongly suggest that HHcy activated the AHR‐CD36 pathway by increasing hepatic LXA4 content, which resulted in HS. (Hepatology 2016; 00:000–000)
Source: Hepatology - April 4, 2016 Category: Internal Medicine Authors: Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
Hyperhomocysteinemia Activates the Aryl Hydrocarbon Receptor‐CD36 Pathway to Promote Hepatic Steatosis in Mice
In conclusion, our results strongly suggest that HHcy activated the AHR‐CD36 pathway by increasing hepatic LXA4 content, which resulted in hepatic steatosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - February 29, 2016 Category: Internal Medicine Authors: Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
