The UPR mediates fibrogenesis and collagen I secretion through regulating TANGO1

Conclusion: Loss of TANGO1 leads to procollagen I retention in the ER which promotes UPR‐mediated HSC apoptosis. TANGO1 regulation during HSC activation occurs through a UPR dependent mechanism that requires the transcription factor XBP‐1. Finally, TANGO1 is critical for fibrogenesis through mediating HSC homeostasis. Our work reveals a unique role for TANGO1 and the UPR in facilitating collagen I secretion and fibrogenesis. This article is protected by copyright. All rights reserved.

Source: Hepatology - November 4, 2016 Category: Internal Medicine Authors: Jessica L Maiers, Enis Kostallari, Malek Mushref, Thiago M de Assuncao, Haiyang Li, Robert C Huebert, Sheng Cao, Harmeet Malhi, Vijay H Shah Tags: Liver Biology and Pathobiology Source Type: research