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Total 101 results found since Jan 2013.
Targeted Delivery of siRNA against Hepatitis B Virus by PreS1 Peptide Molecular Ligand
ConclusionThe results indicated that PreS1‐9Arg may be a potential novel vector to deliver siRNA targeting liver cells.
Source: Hepatology Research - June 28, 2013 Category: Internal Medicine Authors: Wenjuan Huang, Xia Li, Min Yi, Sufen Zhu, Weixian Chen Tags: Original Article Source Type: research
PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide
PD-1-siRNA delivered by attenuated <i>Salmonella</i> enhances the antimelanoma effect of pimozide, Published online: 18 February 2019; doi:10.1038/s41419-019-1418-3PD-1-siRNA delivered by attenuated Salmonella enhances the antimelanoma effect of pimozide
Source: Cell death and disease - February 18, 2019 Category: Internal Medicine Authors: Tiesuo Zhao Tian Wei Jing Guo Yangeng Wang Xiangyi Shi Sheng Guo Xiaolong Jia Huijie Jia Zhiwei Feng Source Type: research
Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
Cell Death & Disease, Published online: 11 May 2020; doi:10.1038/s41419-020-2571-4Lipid-encapsulated siRNA for hepatocyte-directed treatment of advanced liver disease
Source: Cell death and disease - May 10, 2020 Category: Internal Medicine Authors: Marius Maximilian Woitok Miguel Eugenio Zoubek Dennis Doleschel Matthias Bartneck Mohamed Ramadan Mohamed Fabian Kie ßling Wiltrud Lederle Christian Trautwein Francisco Javier Cubero Source Type: research
The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior
Cell Death & Disease, Published online: 12 November 2021; doi:10.1038/s41419-021-04361-9The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior
Source: Cell death and disease - November 12, 2021 Category: Internal Medicine Authors: Yufeng Jia Xiao Zhuang Yi Zhang Ming Zhao Nuo Chen Wen Li Faliang Zhu Chun Guo Yan Li Qun Wang Yuan Li Lining Zhang Source Type: research
In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06159-3In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Lingfeng Yu Gentao Fan Qingyan Wang Yan Zhu Hao Zhu Jiang Chang Zhen Wang Shoubin Zhan Xianming Hua Diankun She Jianhao Huang Yicun Wang Jianning Zhao Chen-Yu Zhang Xi Chen Guangxin Zhou Source Type: research
Role of thymic stromal lymphopoietin in the pathogenesis of lumbar disc degeneration
This study aims to investigate the role of thymic stromal lymphopoietin (TSLP) in the pathogenesis of lumbar disc degeneration (LDD).
Methods: Nucleus pulposus tissues were collected from 77 LDD patients (the case group), in addition, normal tissues were extracted from 21 patients suffering from lumbar fractures (the control group). Immunohistochemistry was applied in order to detect TSLP positive expression. In accordance with varying transfection, the cells were divided into TSLP-siRNA, TSLP-siRNA + TSLPR-siRNA, control, blank, anti-TSLPR, and IgG groups. Western blotting was used in order to detect TSLP expression ...
Source: Medicine - July 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Xuefu Zhuyu Oral Liquid ( 血府逐瘀口服液) Prevents Apoptosis of Ischemic Myocardium Cells in Rats by Regulating SIRT1 and Its Pathway-Related Genes
ConclusionXFZY could prevent myocardial cells apoptosis probably by increasing the mRNA and protein expressions of SIRT1 and inhibiting the mRNA and protein expressions of P53, NF- K B, FoxO1, FoxO3 and FoxO4.
Source: Chinese Journal of Integrative Medicine - December 22, 2019 Category: Internal Medicine Source Type: research
Protecting liver sinusoidal endothelial cells suppresses apoptosis in acute liver damage
ConclusionHepatocyte apoptosis was reduced by the efficient suppression of LSEC apoptosis with a novel DDS. Protecting the sinusoidal structure by suppressing LSEC damage will be an effective treatment for acute liver failure. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - October 22, 2015 Category: Internal Medicine Authors: Tomohito Tanoi, Takafumi Tamura, Naoki Sano, Ken Nakayama, Kiyoshi Fukunaga, Yun‐Wen Zheng, Afsana Akhter, Yu. Sakurai, Yasuhiro Hayashi, Hideyoshi Harashima, Nobuhiro Ohkohchi Tags: Original Article Source Type: research
Targeting CCl4 ‐induced liver fibrosis by RNA interference ‐ mediated inhibition of Cyclin E1 in mice
Conclusion: Therapeutic targeting of CcnE1 in vivo using RNAi is feasible and has high anti‐fibrotic activity. This article is protected by copyright. All rights reserved.
Source: Hepatology - May 1, 2017 Category: Internal Medicine Authors: J örg‐Martin Bangen, Linda Hammerich, Roland Sonntag, Maike Baues, Ute Haas, Daniela Lambertz, Thomas Longerich, Twan Lammers, Frank Tacke, Christian Trautwein, Christian Liedtke Tags: Liver Injury and Regeneration Source Type: research
Targeting CCl4 ‐induced liver fibrosis by RNA interference–mediated inhibition of cyclin E1 in mice
Conclusion: Therapeutic targeting of CcnE1 in vivo using RNAi is feasible and has high antifibrotic activity. (Hepatology 2017).
Source: Hepatology - August 26, 2017 Category: Internal Medicine Authors: J örg‐Martin Bangen, Linda Hammerich, Roland Sonntag, Maike Baues, Ute Haas, Daniela Lambertz, Thomas Longerich, Twan Lammers, Frank Tacke, Christian Trautwein, Christian Liedtke Tags: Liver Injury and Regeneration Source Type: research
Theranostical nanosystem‐mediated identification of an oncogene and highly effective therapy in hepatocellular carcinoma
In conclusion, the theranostic siRNA nanomedicine examined here possesses great theranostic potential for combined gene therapy and MRI diagnosis of HCC. This article is protected by copyright. All rights reserved.
Source: Hepatology - December 1, 2015 Category: Internal Medicine Authors: Yu Guo, Jing Wang, Lu Zhang, Shunli Shen, Ruomi Guo, Yang Yang, Wenjie Chen, Yiru Wang, Guihua Chen, Xintao Shuai Tags: Hepatobiliary Malignancies Source Type: research
BRCA2 protects mammalian cells from heat shock.
CONCLUSION: BRCA2 has a protecting role against heat-induced cell death. BRCA2 might be a potential molecular target for hyperthermic cancer therapy.
PMID: 28891354 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - September 13, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Wnt2 knock down by RNAi inhibits the proliferation of in vitro-cultured human keloid fibroblasts
To study the effect of knocking down wingless-related MMTV integration site 2 (Wnt2) expression by RNAi on the growth and signaling pathways of ex vitro-cultured keloid fibroblasts (KFB).
Human KFB were isolated from 10 keloid patient specimens. The KFB cells were then transfected with 4 pairs of small interfering RNA (siRNA) targeting human Wnt2, respectively. Reverse transcriptase-polymerase chain reaction and Western blot analysis were conducted to verify the knock down of Wnt2, and the expression of β-catenin glycogen synthase kinase-3β (GSK-3β) and cyclin D1 were examined.
siRNA Wnt2 transfection (siWnt2) resulte...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Quality Improvement Study Source Type: research
Evaluation of the Consequence of CTNNB1 & amp; RAB1A Targeting on Hepatocellular Carcinoma Cell Line
ConclusionTargetingCTNNB1or RAB1A in HepG2 cell lines decreased the cell viability and proliferative activity. Moreover, targetingCTNNB1 was effective in decreasing cell proliferative activity compared to targetingRAB1A in HepG2 cell lines. So, targeting CTNNB1 may have a potential therapeutic effect in treatment of HCC.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Loss of SPARC in mouse skeletal muscle causes myofiber atrophy
Discussion: The loss of SPARC not only upregulates atrogin1 expression but also enhances TGFβ signaling, which may in turn cause muscle atrophy. © 2013 Wiley Periodicals, Inc.
Source: Muscle and Nerve - February 1, 2013 Category: Internal Medicine Authors: Katsuyuki Nakamura, Shin‐ichi Nakano, Takahiro Miyoshi, Keitaro Yamanouchi, Masugi Nishihara Tags: Research Article Source Type: research
