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Specialty: Internal Medicine
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Total 101 results found since Jan 2013.
In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Cell Death & Disease, Published online: 22 September 2023; doi:10.1038/s41419-023-06159-3In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy
Source: Cell death and disease - September 22, 2023 Category: Internal Medicine Authors: Lingfeng Yu Gentao Fan Qingyan Wang Yan Zhu Hao Zhu Jiang Chang Zhen Wang Shoubin Zhan Xianming Hua Diankun She Jianhao Huang Yicun Wang Jianning Zhao Chen-Yu Zhang Xi Chen Guangxin Zhou Source Type: research
Current and future options in cholesterol lowering treatments
Eur J Intern Med. 2023 Feb 20:S0953-6205(23)00050-X. doi: 10.1016/j.ejim.2023.02.010. Online ahead of print.ABSTRACTThe relative risk reduction of cardiovascular events is proportional to the absolute reduction in LDL-C levels, the primary target of therapy, no matter the way of reduction. During the last decades, the therapeutic regimens for reducing the LDL-C levels have been immerged and improved, with favorable effects on the atherosclerotic process and clinical benefits of various cardiovascular outcomes. From a practical view of point, this review is focusing only on the current available lipid lowering agents: stati...
Source: European Journal of Internal Medicine - February 22, 2023 Category: Internal Medicine Authors: Avishay Elis Source Type: research
High expression of PYK2 is associated with poor prognosis and cancer progression in early-stage cervical carcinoma
Proline-rich tyrosine kinase-2 (PYK2), also known as calcium dependent tyrosine kinase, regulates different signal transduction cascades that control cell proliferation, migration, and invasion. However, the role of PYK2 in cervical cancer remains to be elucidated. The current study retrospectively included 134 patients with cervical cancer from December 2007 to September 2014. PYK2 expression was detected in tissue microarray and cervical cancer cell lines. Statistical analysis was performed to evaluate its clinicopathological significance. Small interfering RNA (siRNA) was employed to suppress endogenous PYK2 expression ...
Source: Medicine - October 14, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Clinical significance and prospective molecular mechanism of NUF2 in gastric cancer exploration: A comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases
Nuf2 is a combination of silica and spindle microtubules during the cells in the cells, participating in regulatory cell proliferation and apoptosis. Previous studies have shown that the growth of gastric cancer (GC) cells is significantly inhibited after siRNA-mediated Nuf2 gene knockout. However, the expression, survival and molecular mechanism of nuf2 in patients with GC are still unclear.
Source: Medicine - July 1, 2022 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Danlou Tablet Improves Chronic Intermittent Hypoxia-Induced Dyslipidemia and Arteriosclerosis by HIF-1 α-Angptl4 mRNA Signaling Pathway
ConclusionDLT had positive effects in improving dyslipidemia and arteriosclerosis by inhibiting Angptl4 protein level through HIF-1 α-Angptl4 mRNA signaling pathway.
Source: Chinese Journal of Integrative Medicine - May 25, 2022 Category: Internal Medicine Source Type: research
Positive Topline Results for siRNA in Raised Lipoprotein(a) Positive Topline Results for siRNA in Raised Lipoprotein(a)
Significant reductions in Lp(a) were sustained out to 150 days in patients without cardiovascular disease in top-line phase 1 results from the APOLLO study, released by Silence Therapeutics.Medscape Medical News
Source: Medscape Internal Medicine Headlines - February 10, 2022 Category: Internal Medicine Tags: Cardiology News Source Type: news
Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells
CONCLUSION: Our results indicate that UCP2 protects against HS-induced vascular endothelial damage and that it enhances mitochondrial function. These findings reveal that UCP2 can be a potential contributor to mechanism-based therapeutic strategies for HS.PMID:35129048 | DOI:10.1080/02656736.2022.2032846
Source: International Journal of Hyperthermia - February 7, 2022 Category: Internal Medicine Authors: Wei Huang Liangfeng Mao Weidang Xie Sumin Cai Qiaobing Huang Yanan Liu Zhongqing Chen Source Type: research
The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior
Cell Death & Disease, Published online: 12 November 2021; doi:10.1038/s41419-021-04361-9The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior
Source: Cell death and disease - November 12, 2021 Category: Internal Medicine Authors: Yufeng Jia Xiao Zhuang Yi Zhang Ming Zhao Nuo Chen Wen Li Faliang Zhu Chun Guo Yan Li Qun Wang Yuan Li Lining Zhang Source Type: research
The effect of Epitranscriptomic writer (METTL3) silencing on Hepatocellular carcinoma cell line
ConclusionsKnockdown ofMETTL3 in HepG2 cell lines successively reduced cell viability and active proliferative cell count.METTL3 may be involved in liver tumorigenesis and its targeting may be of therapeutic benefit.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Evaluation of the Consequence of CTNNB1 & amp; RAB1A Targeting on Hepatocellular Carcinoma Cell Line
ConclusionTargetingCTNNB1or RAB1A in HepG2 cell lines decreased the cell viability and proliferative activity. Moreover, targetingCTNNB1 was effective in decreasing cell proliferative activity compared to targetingRAB1A in HepG2 cell lines. So, targeting CTNNB1 may have a potential therapeutic effect in treatment of HCC.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
DEAH-box polypeptide 32 promotes hepatocellular carcinoma progression via activating the β-catenin pathway
CONCLUSION: DHX32 was an attractive regulator of HCC progression and indicated DHX32 canserve as a potential biomarker and therapeutic target for HCC patients.PMID:33729094 | DOI:10.1080/07853890.2021.1898674
Source: Annals of Medicine - March 17, 2021 Category: Internal Medicine Authors: Xiaoyun Hu Guosheng Yuan Qi Li Jing Huang Xiao Cheng Jinzhang Chen Source Type: research
Paeoniflorin inhibits the macrophage-related rosacea-like inflammatory reaction through the suppressor of cytokine signaling 3-apoptosis signal-regulating kinase 1-p38 pathway
In conclusion, the pathogenesis of rosacea involves abnormal macrophage infiltration within the lesions. PF inhibits the macrophage-related rosacea-like inflammatory response through the SOCS3-ASK1-p38 pathway, demonstrating its potential application as a novel drug for rosacea therapy.
Source: Medicine - January 22, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
