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Total 101 results found since Jan 2013.

Vitamin D receptor gene silencing effects on differentiation of myogenic cell lines
Conclusions:. Our results suggest that myoblasts require signals transmitted through VDR for differentiation into myocytes and emphasize the importance of VDR expression in skeletal muscles for maintaining muscle volume in the elderly. © 2013 Wiley Periodicals, Inc.
Source: Muscle and Nerve - July 19, 2013 Category: Internal Medicine Authors: Masahiko Tanaka, Koshi N. Kishimoto, Hiroshi Okuno, Hideo Saito, Eiji Itoi Tags: Research Article Source Type: research

Targeted Delivery of siRNA against Hepatitis B Virus by PreS1 Peptide Molecular Ligand
ConclusionThe results indicated that PreS1‐9Arg may be a potential novel vector to deliver siRNA targeting liver cells.
Source: Hepatology Research - June 28, 2013 Category: Internal Medicine Authors: Wenjuan Huang, Xia Li, Min Yi, Sufen Zhu, Weixian Chen Tags: Original Article Source Type: research

PKA dependent p‐Ser‐675β‐catenin, a novel signaling defect in a mouse model of Congenital Hepatic Fibrosis
Conclusions: These data show that in fibrocystin‐defective cholangiocytes, cAMP/PKA signaling stimulates pSer‐675phosphorylation of β‐catenin and Rac‐1 activity. In the presence of activated Rac‐1, pSer‐675‐β‐catenin is translocated to the nucleus, becomes transcriptionally active, and is responsible for increased motility of Pkhd1del4/del4 cholangiocytes. β‐catenin dependent changes in cell motility may be central to the pathogenesis of the disease and represent a potential therapeutic target.. (HEPATOLOGY 2013.)
Source: Hepatology - June 6, 2013 Category: Internal Medicine Authors: Carlo Spirli, Luigi Locatelli, Carola M. Morell, Romina Fiorotto, Stuart D. Morton, Massimiliano Cadamuro, Luca Fabris, Mario Strazzabosco Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Signal transducer and activator of transcription 3 (STAT3) is a pro‐viral host factor for hepatitis C virus
Conclusion: We have demonstrated that STAT3 plays a role in the life cycle of HCV and have clarified the role of STAT3 as a pro‐viral host factor. (HEPATOLOGY 2013.)
Source: Hepatology - May 22, 2013 Category: Internal Medicine Authors: Erin M. McCartney, Karla J. Helbig, Sumudu K. Narayana, Nicholas S. Eyre, Amanda L. Aloia, Michael R. Beard Tags: Viral Hepatitis Source Type: research

MicroRNA‐140‐5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellular carcinoma
Conclusion: These data elucidated a tumor suppressor role for miR‐140‐5p in HCC development and progression with therapeutic potential. Our correlation studies in clinical HCC samples further suggest that miR‐140‐5p could be a valuable biomarker for HCC prognosis. (Hepatology 2013 )
Source: Hepatology - May 14, 2013 Category: Internal Medicine Authors: Hao Yang, Feng Fang, Ruimin Chang, Lianyue Yang Tags: Hepatobiliary Malignancies Source Type: research

Intellectual disability associated with a homozygous missense mutation in THOC6
Conclusion: Our findings associate a missense mutation in THOC6 with intellectual disability, suggesting the THO/TREX complex plays an important role in neurodevelopment.
Source: Orphanet Journal of Rare Diseases - April 26, 2013 Category: Internal Medicine Authors: Chandree BeaulieuLijia HuangA InnesMarie-Andree AkimenkoErik PuffenbergerCharles SchwartzPaul JerryCarole OberRobert HegeleD McLeodJeremy SchwartzentruberJacek MajewskiDennis BulmanJillian ParboosinghKym Boycott Source Type: research

Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
In this study we examined the pathobiological functions and molecular mechanisms of Hh signaling pathway in HCC cells. Treatment of cultured human HCC cells (Huh7, Hep3B and HepG2) with the Hh signaling ligand (recombinant Shh) or agonist, SAG and purmorphamine, prevented the induction of autophagy. In contrast, GANT61 (a small molecule inhibitor of Gli1 and Gli2) induced autophagy, as determined by immunobloting for microtubule‐associated protein light chain 3 (LC3) and p62, GFP‐LC3 puncta, monodansylcadaverine (MDC) staining and transmission electron microscopy. Hh inhibition‐induced autophagy was associated with u...
Source: Hepatology - March 16, 2013 Category: Internal Medicine Authors: Ying Wang, Chang Han, Lu Lu, Susan Magliato, Tong Wu Tags: Hepatobiliary Malignancies Source Type: research

Epigenetic regulation of methionine adenosyltransferase 1A; a role for microRNA‐based treatment in liver cancer?
In conclusion, upregulation of miR‐664, miR‐485‐3p, and miR‐495 contributes to lower MAT1A expression in HCC, and enhanced tumorigenesis may provide potential targets for HCC therapy. (HEPATOLOGY 2013.)
Source: Hepatology - March 6, 2013 Category: Internal Medicine Authors: Jens U. Marquardt, Peter R. Galle Tags: Hepatology Elsewhere Source Type: research

MicroRNA‐140‐5p suppresses tumor growth and metastasis by targeting TGFBR1 and FGF9 in hepatocellular carcinoma
Abstract By comparing the expression profiles of miRNAs in different HCC subtypes, we identified miR‐140‐5p as a HCC related miRNA. We found that miR‐140‐5p was significantly decreased in HCC tissues and all of six liver cancer cell lines examined and its expression levels were correlated with multiple nodules, vein invasion, capsular formation, and differentiation, as well as overall and disease‐free survival of HCC. We also found that miR‐140‐5p suppressed HCC cell proliferation and HCC metastasis. Multi‐pathway reporter arrays suggested that miR‐140‐5p inhibited TGF‐βand MAPK/ERK signaling. TGFBR1...
Source: Hepatology - February 1, 2013 Category: Internal Medicine Authors: Hao Yang, Feng Fang, Ruimin Chang, Lianyue Yang Tags: Hepatobiliary Malignancies Source Type: research

Loss of SPARC in mouse skeletal muscle causes myofiber atrophy
Discussion: The loss of SPARC not only upregulates atrogin1 expression but also enhances TGFβ signaling, which may in turn cause muscle atrophy. © 2013 Wiley Periodicals, Inc.
Source: Muscle and Nerve - February 1, 2013 Category: Internal Medicine Authors: Katsuyuki Nakamura, Shin‐ichi Nakano, Takahiro Miyoshi, Keitaro Yamanouchi, Masugi Nishihara Tags: Research Article Source Type: research

Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin‐8 channels
Conclusion: Hepatocyte mtAQP8 channels facilitate the mitochondrial uptake of ammonia and its metabolism into urea, mainly under glucagon stimulation. This mechanism may be relevant to hepatic ammonia detoxification and in turn, avoid the deleterious effects of hyperammonemia. (HEPATOLOGY 2013.)
Source: Hepatology - January 8, 2013 Category: Internal Medicine Authors: Leandro R. Soria, Julieta Marrone, Giuseppe Calamita, Raúl A. Marinelli Tags: Liver Biology and Pathobiology Source Type: research