Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin‐8 channels

Conclusion: Hepatocyte mtAQP8 channels facilitate the mitochondrial uptake of ammonia and its metabolism into urea, mainly under glucagon stimulation. This mechanism may be relevant to hepatic ammonia detoxification and in turn, avoid the deleterious effects of hyperammonemia. (HEPATOLOGY 2013.)

Source: Hepatology - January 8, 2013 Category: Internal Medicine Authors: Leandro R. Soria, Julieta Marrone, Giuseppe Calamita, Raúl A. Marinelli Tags: Liver Biology and Pathobiology Source Type: research