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Total 59 results found since Jan 2013.

Assessment of cervical lymph node metastasis based on total RNA from saliva and tumor tissue in patients with oral squamous cell carcinoma: An observational study
Conclusion: Saliva and tumor tissue RNA can be a good marker for pretreatment assessment of lymph node metastasis in patients with OSCC. Although the diagnostic accuracy which range from 63% to 65%, further characterization and study of specific mRNA, siRNA and miRNA may come out with high diagnostic accuracy.
Source: Journal of Oral and Maxillofacial Pathology - September 8, 2020 Category: ENT & OMF Authors: Kiran B Jadhav Vandana Shah Ghansham Parmar Nirali Chauhan Naveen Shah Nidhi Gupta Source Type: research

Glyoxal and Methylglyoxal as E-cigarette Vapor Ingredients-Induced Pro-Inflammatory Cytokine and Mucins Expression in Human Nasal Epithelial Cells.
CONCLUSIONS: GO and MGO induced pro-inflammatory cytokines and MUC5AC/5B expression via ERK1/2, p38 MAPK, and NF-κB in human nasal epithelial cells. These results suggested that GO and MGO may be involved in mucus hypersecretion-related airway diseases. PMID: 32746708 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - August 2, 2020 Category: ENT & OMF Authors: Kwak S, Choi YS, Na HG, Bae CH, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Ladinin-1 is involved in cell motility and proliferation of oral squamous cell carcinoma cells
ConclusionsLAD1 is potentially involved in modulation of actin dynamics in oral SCC cells, affecting their motility and proliferation at the interface between cancer and non-cancerous tissue.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Opg and bcl-2 promote ameloblastoma cell tumorigenesis and predict prognosis for ameloblastoma patients
Publication date: July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 1Author(s): Ms. Jueyoung Kim, Ms. Jinsun Kim, Dr. Shadavlonjid Bazarsad, Prof. Sung-won Cho, Prof. Jin KimAmeloblastoma is the most frequent odontogenic epithelial tumor in the jaw. Though ameloblastoma belongs to benign odontogenic tumors, it exhibits a locally aggressive behavior with high recurrence rate. However, molecular markers predicting the recurrence have not been reported yet. The aim of this study was to find the prognostic markers in ameloblastoma. To detect apoptosis-related genes showing diffe...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Impacts of CD40- and CD86-Silenced Antigen-Specific B Cells on the Control of Allergies.
CONCLUSION: This study showed, for the first time, that siRNA-induced CD86-silenced B cells significantly inhibited allergic responses and symptoms antigen-specifically, and that siRNA-induced CD40-/CD86-silenced antigen-specific B cells are a more useful antigen-specific therapy than CD40- or CD86-silenced B cells alone for the control of allergies. Furthermore, it was shown that CD40-/CD86-silenced B cells have stronger inhibition of IgE production and allergic symptoms than CD40-/CD86-silenced DCs. PMID: 31064207 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - May 7, 2019 Category: ENT & OMF Authors: Suzuki M, Matsumoto T, Toyoda K, Nakamura Y, Murakami S Tags: Am J Rhinol Allergy Source Type: research

Inhibition of Histone Methyltransferase G9a Attenuates Noise-Induced Cochlear Synaptopathy and Hearing Loss
In this study, we investigated the effect of G9a (KMT1C, EHMT2), a major histone lysine methyltransferase encoded by the humanEHMT2 gene and responsible for histone H3 lysine 9 dimethylation (H3K9me2) on noise-induced permanent hearing loss (NIHL) in adult CBA/J mice. The conditions of noise exposure used in this study led to losses of cochlear synapses and outer hair cells (OHCs) and permanent auditory threshold shifts. Inhibition of G9a with its specific inhibitor BIX 01294 or with siRNA significantly attenuated these pathological features. Treatment with BIX 01294 also prevented the noise-induced decrease of KCNQ4 immun...
Source: JARO - Journal of the Association for Research in Otolaryngology - February 1, 2019 Category: ENT & OMF Source Type: research

Endoplasmic Reticulum Stress Induces MUC5AC and MUC5B Expression in Human Nasal Airway Epithelial Cells.
Conclusion: These results demonstrate that ER stress plays an important role in the regulation of MUC5AC and MUC5B via the activations of XBP-1, CHOP, and ATF6 in human nasal airway epithelial cells. PMID: 30336657 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - October 20, 2018 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Interleukin (IL) 36 gamma induces mucin 5AC, oligomeric mucus/gel-forming expression via IL-36 receptor-extracellular signal regulated kinase 1 and 2, and p38-nuclear factor kappa-light-chain-enhancer of activated B cells in human airway epithelial cells.
CONCLUSION: These results indicated that IL-36 gamma induced MUC5AC expression via the IL-36 receptor-mediated ERK1/2 and p38/NF-kappa B pathway in human airway epithelial cells. PMID: 29644902 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - March 1, 2018 Category: ENT & OMF Authors: Bae CH, Choi YS, Na HG, Song SY, Kim YD Tags: Am J Rhinol Allergy Source Type: research

Clusterin Induces MUC5AC Expression via Activation of NF- κB in Human Airway Epithelial Cells.
Conclusion: These results suggest that nCLU induces MUC5AC expression via the activation of NF-κB signaling pathway in human airway epithelial cells. PMID: 29316784 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - January 12, 2018 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Nanoparticle delivery of RNA ‐based therapeutics to alter the vocal fold tissue response to injury
ConclusionsThe current study is the first to demonstrate targeted gene manipulation in the VFs as well as the potential utility of lipitoid for localized delivery of genetic material in vivo. Ideally, these data will serve as a platform for future investigation regarding the functional implications of therapeutic gene manipulation in the VFs. Level of EvidenceNA Laryngoscope, 2017
Source: The Laryngoscope - December 14, 2017 Category: ENT & OMF Authors: Nao Hiwatashi, Iv Kraja, Peter A. Benedict, Gregory R. Dion, Renjie Bing, Bernard Rousseau, Milan R. Amin, Danielle M. Nalband, Kent Kirshenbaum, Ryan C. Branski Tags: Laryngology Source Type: research

SMAD3 expression and regulation of fibroplasia in vocal fold injury
ConclusionCumulatively, these data support SMAD3 as a potential master regulator of TGF‐β‐mediated fibrosis. SMAD3 transcription peaked 7 days following injury. Multi‐gene analysis indicated that the therapeutic effectiveness of SMAD3 knockdown may be related to regulation of downstream mediators of fibroplasia and altered TGF‐β signaling. Level of EvidenceNA. Laryngoscope, 2017
Source: The Laryngoscope - May 21, 2017 Category: ENT & OMF Authors: Nao Hiwatashi, Peter A. Benedict, Gregory R. Dion, Renjie Bing, Iv Kraja, Milan R. Amin, Ryan C. Branski Tags: Laryngology Source Type: research

Experimental Study on 1,25(OH)2D3 Amelioration of Oral Lichen Planus through Regulating NF ‐κB Signaling Pathway
ConclusionThese results suggest that 1,25(OH)2D3 plays an anti‐inflammatory role in OLP by mediating NF‐κB signaling pathway but not AP‐1 signaling pathway with a VDR‐dependent manner, predicting vitamin D supplement may be a potential strategy for the OLP management.This article is protected by copyright. All rights reserved.
Source: Oral Diseases - February 22, 2017 Category: ENT & OMF Authors: Jie Du, Ran Li, Feiyan Yu, Fang Yang, Jinhua Wang, Qingyong Chen, Xiangyu Wang, Bin Zhao, Fang Zhang Tags: Original Article Source Type: research

Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts
ConclusionLipitoid effectively knocked down Smad3 expression across multiple transfection conditions. These preliminary data are encouraging, and lipitoid warrants further investigation with the goal of clinical utility. Level of EvidenceNA. Laryngoscope, 2016
Source: The Laryngoscope - November 30, 2016 Category: ENT & OMF Authors: Iv Kraja, Renjie Bing, Nao Hiwatashi, Bernard Rousseau, Danielle Nalband, Kent Kirshenbaum, Ryan C. Branski Tags: Laryngology Source Type: research

Effect of High Glucose on MUC5B Expression in Human Airway Epithelial Cells.
Conclusion: These findings suggest that HG induces MUC5B expression via the sequential activations of the EGFR/p38 MAPK signaling pathway in human airway epithelial cells. PMID: 27384035 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Otorhinolaryngology - July 9, 2016 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss
In this study, we investigated the effect of noise exposure on histone H3 lysine 9 acetylation (H3K9ac) in the inner ear of adult CBA/J mice and determined if inhibition of histone deacetylases by systemic administration of suberoylanilide hydroxamic acid (SAHA) could attenuate NIHL. Our results showed that H3K9ac was decreased in the nuclei of outer hair cells (OHCs) and marginal cells of the stria vascularis in the basal region after exposure to a traumatic noise paradigm known to induce permanent threshold shifts (PTS). Consistent with these results, levels of histone deacetylases 1, 2, and 3 (HDAC1, HDAC2 and HDAC3) we...
Source: JARO - Journal of the Association for Research in Otolaryngology - April 18, 2016 Category: ENT & OMF Source Type: research