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Total 76 results found since Jan 2013.
Increased Dynamin ‐Related Protein 1–Dependent Mitochondrial Fission Contributes to High‐Fat‐Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn HF ‐diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signaling pathway and alleviates insulin resistance.
Source: Molecular Nutrition and Food Research - January 18, 2019 Category: Food Science Authors: Wenguang Chang,
Dandan Xiao,
Xiang Ao,
Mengyang Li,
Tao Xu,
Jianxun Wang Tags: Research Article Source Type: research
Increased Dynamin ‐Related Protein 1‐Dependent Mitochondrial Fission Contributes to High‐Fat Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn high ‐fat diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signalling pathway and alleviates insulin resistance.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 10, 2019 Category: Food Science Authors: Wenguang Chang,
Dandan Xiao,
Xiang Ao,
Mengyang Li,
Tao Xu,
Jianxun Wang Tags: Research Article Source Type: research
Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo.
Abstract
Phthalates are being suggested to be associated with altered thyroid function and proliferative changes, but detailed mechanisms remain unclear. Here, we examined the effects of di-(2-ethylhexyl) phthalate (DEHP) on DNA damage and proliferation in thyroid using thyroid carcinoma cell line, 8505C, in vitro and the rats orally treated with DEHP at 0, 0.3, 3, 30 and 150 mg/kg for 90 days from post-natal day 9 in vivo. Exposure to DHEP (1-50 μM) induced cellular proliferation, as evidenced by increased cell viability and DNA synthesis. Activation of γH2AX, a sensitive biomarker for DNA damage was observ...
Source: Food and Chemical Toxicology - December 10, 2018 Category: Food Science Authors: Kim S, Park GY, Yoo YJ, Jeong JS, Nam KT, Jee SH, Lim KM, Lee YS Tags: Food Chem Toxicol Source Type: research
Camptothecin enhances c-Myc-mediated endoplasmic reticulum stress and leads to autophagy by activating Ca2+-mediated AMPK.
In this study, we found that CPT enhanced c-Myc expression and that the transient knockdown of c-Myc abrogated reactive oxygen species (ROS) generation, which resulted in the accumulation of ER stress-regulating proteins, such as PERK, eIF2α, ATF4, and CHOP. Moreover, the transfection of eIF2α-targeted siRNA attenuated CPT-induced autophagy and decreased the levels of Beclin-1 and Atg7, which indicated that CPT upregulated ER stress-mediated autophagy. In addition, CPT phosphorylated AMPK in response to intracellular Ca2+ release. Ca2+ chelators, ethylene glycol tetraacetic acid and a CaMKII inhibitor, K252a, decreased C...
Source: Food and Chemical Toxicology - September 25, 2018 Category: Food Science Authors: Jayasooriya RGPT, Dilshara MG, Karunarathne WAHM, Molagoda IMN, Choi YH, Kim GY Tags: Food Chem Toxicol Source Type: research
Apoptotic cell death induced by Z-Ligustilidein human ovarian cancer cells and role of NRF2.
Abstract
Z-Ligustilide is the most potent bioactive component of Angelica sinensis, which is widely used in Chinese traditional medicine. Z-Ligustilide selectively affected ovarian cancer cell survival in a dose dependent manner. Z-Ligustilide induced apoptotic cell death was determined by flow cytometry. We also demonstrated that apoptotic cell death was triggered by Z-Ligustilideinduced oxidative stress and mitochondria played an active role. Mitochondrial polarization was reduced by Z-Ligustilidewhereas mitochondrial superoxide formation was increased. NRF2 was induced by Z-Ligustilide in OVCAR-3 cells at epi...
Source: Food and Chemical Toxicology - September 20, 2018 Category: Food Science Authors: Lang F, Qu J, Yin H, Li L, Zhi Y, Liu Y, Fang Z, Hao E Tags: Food Chem Toxicol Source Type: research
Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines.
Abstract
Metastasis is commonly seen in advanced stage of cancers, and matrix metalloproteinases (MMPs) are commonly up-regulated and have been identified as critical regulators. In this present study, a flavonoid, fisetin, which can be found in diverse foods, is investigated for its ability to inhibit cell motility, and the underlying mechanism is also studied in breast cancer cells (4T1 and JC cells). We have revealed that fisetin increased HO-1 mRNA and protein expressions. Besides, fisetin also elevated Nrf2 expression in nuclear fraction. By silencing Nrf2, fisetin-induced HO-1 expression was abrogated, sugge...
Source: Food and Chemical Toxicology - August 1, 2018 Category: Food Science Authors: Tsai CF, Chen JH, Chang CN, Lu DY, Chang PC, Wang SL, Yeh WL Tags: Food Chem Toxicol Source Type: research
Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
In conclusion, OXY increases NAD+ levels, resulting in the stimulation of MUC2 expression in LS 174T cells. These findings present a novel role for NAD+ in stimulation of MUC2 expression.
PMID: 29935245 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - June 20, 2018 Category: Food Science Authors: Hwang D, Jo H, Ma SH, Lim YH Tags: Food Chem Toxicol Source Type: research
Potential role of nucleoside diphosphate kinase in myricetin-induced selective apoptosis in colon cancer HCT-15 cells.
In this study, we evaluated the anti-cancer effects induced by MYR treatment in colon cancer HCT-15 cells. To detect cell proliferation, we conducted MTT assay and real time-cell electronic sensing (RT-CES). We next performed comet assay and Annexin V and PI staining to detect cellular apoptotic features. After that, we conducted two-dimensional electrophoresis (2-DE) analysis to identify apoptotic proteins. The results of this analysis revealed that eight spots were differentially expressed. Among the spots, we selected nucleoside diphosphate kinase (NDPK) for further investigation, as it has been shown to regulate canc...
Source: Food and Chemical Toxicology - April 23, 2018 Category: Food Science Authors: Lee JH, Choi YJ, Park SH, Nam MJ Tags: Food Chem Toxicol Source Type: research
TGF- β1 acts as mediator in fluoride-induced autophagy in the mouse osteoblast cells.
TGF-β1 acts as mediator in fluoride-induced autophagy in the mouse osteoblast cells.
Food Chem Toxicol. 2018 Mar 02;:
Authors: Zhao Y, Li Y, Gao Y, Yuan M, Manthari RK, Wang J, Wang J
Abstract
It is well known that excess fluoride intake can result in fluorosis, which is a serious public health problem. TGF-β1 affects a wide variety of cellular activities and plays an important role in fluorosis. Recent literature proved that fluoride induces autophagy, however, the mechanism is still unclear, and the role of TGF-β1 in the fluoride-induced autophagy should be further illustrated. Therefore, in this...
Source: Food and Chemical Toxicology - March 2, 2018 Category: Food Science Authors: Zhao Y, Li Y, Gao Y, Yuan M, Manthari RK, Wang J, Wang J Tags: Food Chem Toxicol Source Type: research
Essential roles of Akt/Snail pathway in microcystin-LR-induced tight junction toxicity in Sertoli cell.
Abstract
Microcystin (MC)-LR is a cyclic heptapeptide that acts as a potent reproductive system toxin. However, the underlying pathways of MCLR-induced reproductive system toxicity have not been well elucidated. The blood-testis barrier is mainly constituted by tight junctions (TJs) between adjacent Sertoli cells in the seminiferous epithelium near the basement membrane. The present study was designed to investigate changes in TJs and the underlying pathway in MC-LR-induced TJs toxicity in Sertoli cell. In our study, the transepithelial electrical resistance (TER) value was decreased in a dose dependent manner due...
Source: Food and Chemical Toxicology - January 4, 2018 Category: Food Science Authors: Zhou Y, Geng X, Chen Y, Shi H, Yang Y, Zhu C, Yu G, Tang Z Tags: Food Chem Toxicol Source Type: research
Dual-Targeting Multifuntional Mesoporous Silica Nanocarrier
for Codelivery of siRNA and Ursolic Acid to Folate Receptor Overexpressing
Cancer Cells
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.7b03047
Source: Journal of Agricultural and Food Chemistry - August 3, 2017 Category: Food Science Authors: Guirong Zheng, Yiling Shen, Ruirui Zhao, Fan Chen, Ying Zhang, Aixiao Xu and Jingwei Shao Source Type: research
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Abstract
Inhibiting collagen generation is one effective method to treat liver fibrosis. Dioscin showed protective effect against liver fibrosis in our previous studies, and in the present work, SILAC-based proteomics was employed to test the underlying mechanism. A total of 121 differentially expressed proteins caused by dioscin in LX-2 cells were found, and dioscin significantly decreased the expression levels of FN, FAK1, ITGA5, p-PI3K/PI3K, p-Akt/Akt, p-mTOR/mTOR, Col1a1, Col1a2, Col2a1, Col5a1, Col6a1, and increased 2ABB level in vivo and in vitro. Thus, we elucidated that dioscin specifically suppressed col...
Source: Food and Chemical Toxicology - July 6, 2017 Category: Food Science Authors: Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J Tags: Food Chem Toxicol Source Type: research
The anti ‐inflammatory effects of Morin hydrate in atherosclerosis is associated with autophagy induction through cAMP signaling
Conclusion: Our results suggest that anti‐AS and anti‐inflammatory effects of MO are largely associated with its induction of autophagy through stimulation of cAMP‐PKA‐AMPK‐SIRT1 signaling pathway.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - April 1, 2017 Category: Food Science Authors: Yue Zhou, Zhan ‐Qi Cao, Hong‐Yuan Wang, Yan‐Na Cheng, Lu‐Gang Yu, Xin‐Ke Zhang, Yan Sun, Xiu‐Li Guo Tags: Research Article Source Type: research
Inhibition of JNK by pi class of glutathione S-transferase through PKA/CREB pathway is associated with carnosic acid protection against 6-hydroxydopamine-induced apoptosis.
CONCLUSION: CA prevents 6-OHDA-induced apoptosis via inhibition of JNK by GSTP through the PKA/CREB pathway.
PMID: 28288932 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - March 9, 2017 Category: Food Science Authors: Lin CY, Fu RH, Chou RH, Chen JH, Wu CR, Chang SW, Tsai CW Tags: Food Chem Toxicol Source Type: research
Fructose down ‐regulates miR‐330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin
Conclusion: These findings suggest that morin protects against fructose‐induced kidney insulin signaling impairment by up‐regulating miR‐330 to reduce inflammatory response. Morin may be a potential therapeutic agent for the treatment of kidney injury associated with fructose‐induced inflammation and insulin signaling impairment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 31, 2017 Category: Food Science Authors: Ting ‐Ting Gu, Lin Song, Tian‐Yu Chen, Xin Wang, Xiao‐Juan Zhao, Xiao‐Qin Ding, Yan‐Zi Yang, Ying Pan, Dong‐Mei Zhang, Ling‐Dong Kong Tags: Research Article Source Type: research
