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Total 76 results found since Jan 2013.
Epigallocatechin Gallate Induces Up ‐Regulation of LDL Receptor via the 67 kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Kumiko Zanka,
Yuya Kawaguchi,
Yudai Okada,
Satoshi Nagaoka Tags: Research Article Source Type: research
Gut metabolite, Urolithin A decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUrolithin A leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary Urolithin A in cancer prevention or as adjuvant therapy is promising.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Md Alauddin,
Toshiyuki Okumura,
Janet Rajaxavier,
Shayan Khozooei,
Simone P öschel,
Satoru Takeda,
Yogesh Singh,
Sara Y Brucker,
Diethelm Wallwiener,
André Koch1,
Madhuri S Salker Tags: Research Article Source Type: research
The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway.
Abstract
To investigate the anti-tumor activities of WZ35 and its possible molecular mechanism, bioinformatics analysis and the hematoxylin-eosin (HE) staining were applied to evaluate the Yes-associated-protein (YAP) level in gastric cancer. Cell counting kit-8 (CCK-8) was used to examine cell viability. Apoptosis was determined by flow cytometry analysis. Seahorse bioenergetics analyzer was used to investigate the alteration of oxygen consumption and aerobic glycolysis rate. SiRNA transfection was applied to silence endogenous YAP. Western blot was performed to detect indicated proteins. We found that treatment ...
Source: Food and Chemical Toxicology - January 16, 2020 Category: Food Science Authors: Chen T, Zhao L, Chen S, Zheng B, Chen H, Zeng T, Sun H, Zhong S, Wu W, Lin X, Wang L Tags: Food Chem Toxicol Source Type: research
Upregulation of OPA1 by carnosic acid is mediated through induction of IKK γ ubiquitination by parkin and protects against neurotoxicity.
In conclusion, the mechanism by which CA counteracts the toxicity of 6-OHDA is through modulation of mitochondrial dynamics and upregulation of OPA1 via activation of the parkin/IKKγ/p65 pathway.
PMID: 31705926 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - November 5, 2019 Category: Food Science Authors: Lin CY, Chen WJ, Fu RH, Tsai CW Tags: Food Chem Toxicol Source Type: research
Punicalagin, a Pomegranate ‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
ConclusionsPCG ameliorated obesity and obesity ‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - August 23, 2019 Category: Food Science Authors: Bobin Kang,
Chae Young Kim,
Jisu Hwang,
Kyungae Jo,
Singeun Kim,
Hyung Joo Suh,
Hyeon ‐Son Choi Tags: Research Article Source Type: research
Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.Graphical abstractThis diagram illustrated that quercetin treatment effectively attenuated RAGE expression to facilitate autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 and MIA Paca-2 GEMR cells.
Source: Journal of Food and Drug Analysis - August 22, 2019 Category: Food Science Source Type: research
Attenuation of Palmitic Acid –Induced Lipotoxicity by Chlorogenic Acid through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protects hepatocytes from FFA ‐induced lipotoxicity through activation of SIRT1, which reverses the oxidative stress and dysfunction of mitochondrial biogenesis directly.
Source: Molecular Nutrition and Food Research - June 12, 2019 Category: Food Science Authors: Lele Yang,
Jinchao Wei,
Feiya Sheng,
Peng Li Tags: Research Article Source Type: research
Attenuation of Palmitic Acid ‐Induced Lipotoxicity by Chlorogenic Acid Through Activation of SIRT1 in Hepatocytes
ConclusionCollectively, these findings show that supplementation with CGA protected hepatocytes from FFAs ‐induced lipotoxicity through activation of SIRT1, which reversed the oxidative stress and dysfunction of mitochondrial biogenesis directly.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - June 4, 2019 Category: Food Science Authors: Lele Yang,
Jinchao Wei,
Feiya Sheng,
Peng Li Tags: Research Article Source Type: research
ASAP Dynamic Cytosine DNA Methylation Patterns Associated with mRNA and siRNA Expression Profiles in Alternate Bearing Apple Trees
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b00871
Source: Journal of Agricultural and Food Chemistry - April 30, 2019 Category: Food Science Authors: Sheng Fan, Xiuhua Gao, Cai Gao, Yang Yang, Xinzheng Zhu, Wei Feng, Ruimin Li, Muhammad Mobeen Tahir, Dong Zhang, Mingyu Han, Na An Source Type: research
Luteolin Ameliorates Testis Injury and Blood –Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43
ConclusionLuteolin is identified as a novel active ingredient that contributes to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by upregulating Cx43.
Source: Molecular Nutrition and Food Research - April 15, 2019 Category: Food Science Authors: Bo Ma,
Jie Zhang,
Zhiming Zhu,
Ang Zhao,
Yanfen Zhou,
Hanjie Ying,
Qi Zhang Tags: Research Article Source Type: research
The Matrix Metalloproteinase ‐13 Inhibitor Poricoic Acid ZI Ameliorates Renal Fibrosis by Mitigating Epithelial‐Mesenchymal Transition
ConclusionsThe findings indicate that as a specific MMP ‐13 inhibitor, PZI attenuates EMT and renal fibrosis. Therefore, the MMP‐13 inhibitor PZI could be a novel therapeutic candidate for limiting EMT and renal fibrosis.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 28, 2019 Category: Food Science Authors: Lin Chen,
Gang Cao,
Ming Wang,
Ya ‐Long Feng,
Dan‐Qian Chen,
Nosratola D. Vaziri,
Shougang Zhuang,
Ying‐Yong Zhao Tags: Research Article Source Type: research
Luteolin Ameliorates Testis Injury and Blood ‐Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Up‐Regulating Cx43
Conclusion: Luteolin was identified as a novel active ingredient that contributed to the protective activity in testicular damage through activating the Nrf2 signaling pathway and by up ‐regulating Cx43.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 28, 2019 Category: Food Science Authors: Bo Ma,
Jie Zhang,
Zhiming Zhu,
Ang Zhao,
Yanfen Zhou,
Hanjie Ying,
Qi Zhang Tags: Research Article Source Type: research
Camptothecin induces c-Myc- and Sp1-mediated hTERT expression in LNCaP cells: Involvement of reactive oxygen species and PI3K/Akt.
Abstract
Camptothecin (CPT), a quinoline alkaloid isolated from Camptotheca acuminate, targets topoisomerase I, which is continuously expressed in cancer cells. However, the molecular mechanisms responsible for CPT-induced telomerase inhibition remain unclear. Unexpectedly, we found that CPT upregulates hTERT expression and concomitantly increases telomerase activity. However, transfection of hTERT-targeting siRNA had no effect on CPT-induced G2/M phase arrest, suggesting that CPT-induced telomerase activation was not related to G2/M phase arrest. CPT simultaneously increased Nrf2 expression and the level of intra...
Source: Food and Chemical Toxicology - March 5, 2019 Category: Food Science Authors: Dilshara MG, Jayasooriya RGPT, Choi YH, Kim GY Tags: Food Chem Toxicol Source Type: research
PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells.
In conclusion, CA appears to counteract the neurotoxicity of 6-OHDA by activating PINK1/parkin-mediated mitophagy.
PMID: 30707903 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - January 29, 2019 Category: Food Science Authors: Lin CY, Tsai CW Tags: Food Chem Toxicol Source Type: research
Increased Dynamin ‐Related Protein 1–Dependent Mitochondrial Fission Contributes to High‐Fat‐Diet‐Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts
ConclusionIn HF ‐diet‐fed mouse hearts, increased tafazzin contributes to insulin resistance via mediating Drp‐1 translocation to the mitochondria, and a small non‐coding RNA, miR‐125b‐5p, at least partially regulates this signaling pathway and alleviates insulin resistance.
Source: Molecular Nutrition and Food Research - January 18, 2019 Category: Food Science Authors: Wenguang Chang,
Dandan Xiao,
Xiang Ao,
Mengyang Li,
Tao Xu,
Jianxun Wang Tags: Research Article Source Type: research
