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Total 76 results found since Jan 2013.

Butyrate Improves Porcine Endometrial Epithelial Cell Receptivity via Enhancing Acetylation of Histone H3K9
ConclusionThe findings reveal that butyrate improves endometrial epithelial cell receptivity by enhancing the acetylation of histone H3K9, which shows nutritional regulation and therapeutic potential for poor uterine receptivity and difficulty in embryo implantation.
Source: Molecular Nutrition and Food Research - July 8, 2023 Category: Food Science Authors: Qianhong Ye, Haoyu Li, Baoyang Xu, Ziyi He, Xianghua Yan Tags: Research Article Source Type: research

DBP induced autophagy and necrotic apoptosis in HepG2 cells via the mitochondrial damage pathway
In this study, HepG2 cells were treated with 0.0625, 0.125, 0.25, 0.5 and 1 mM Dibutyl phthalate (DBP) for 48 h to investigate mitochondrial toxicity. The results showed that DBP caused mitochondrial damage, autophagy, apoptosis and necroptosis; Transcriptomics analysis identified that MAPK and PI3K were significant factors in the cytotoxic changes induced by DBP; N-Acetyl-L-cysteine (NAC), SIRT1 activator, ERK inhibitor, p38 inhibitor and ERK siRNA treatments counteracted the changes of SIRT1/PGC-1α and Nrf2 pathway-related proteins, autophagy and necroptotic apoptosis proteins induced by DBP. While PI3K and Nrf2 inhibit...
Source: Food and Chemical Toxicology - April 14, 2023 Category: Food Science Authors: Huan Liu Linjing Xu Lizi Zhou Wenna Han Zhongyi Li Chunhong Liu Source Type: research

Farnesoid X Receptor (FXR) Regulates mTORC1 Signaling and Autophagy by Inhibiting SESN2 Expression
ConclusionThese results indicate that FXR-induced decrease in SESN2 expression and activation of the mTORC1 pathway could control autophagy and be explored as potential therapeutic targets for enterohepatic and metabolic disorders.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 31, 2023 Category: Food Science Authors: GuoYan Wang, Lei Chen, SenLin Qin, HuiJun Geng, Chao Xia, YiNing Zheng, XinJian Lei, Jun Zhang, ShengRu Wu, JunHu Yao, Lu Deng Tags: Research Article Source Type: research

Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin
In this study, however, autophagy and mTOR were found to be inhibited simultaneously by curcumin treatments, and both of them played an important role in the effect of curcumin on suppressing the growth of A549 cells. Tunicamycin (TM), the activator of Endoplasmic Reticulum (ER) stress, increased both autophagy and AKT/mTOR, while curcumin could significantly decrease TM-induced autophagy and AKT/mTOR. Furthermore, curcumin could inhibit TM-induced aerobic glycolysis in A549 cells, and decrease the level of cycle-related and migration-related proteins. Blocking activating transcription factor 4 (ATF4) by siRNA strongly red...
Source: Food and Chemical Toxicology - January 14, 2023 Category: Food Science Authors: Jie Yang None Hasenbilige Shibo Bao Shengxiang Luo Liping Jiang Qiujuan Li Ying Kong Jun Cao Source Type: research

Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS/MAPK/NF- κB signaling pathway in vivo and in vitro
This study aimed to research the effects and related mechanism of HYP on Cd-induced kidney damage. Wide-type and NLRP3-/- mice were used to determine the role of NLRP3 inflammasome in Cd-induced renal dysfunction. Female C57BL/6 were treated with Cd (50 m,g/L) and HYP (25, 50 mg/kg) for 12 weeks. In vitro experiments, the human renal proximal-tubule epithelial cells (RPTEC/TERT1) were pretreated with HYP (50-200 μM) before exposure to Cd. NLRP3 deficiency attenuated Cd-induced NLRP3 activation, inflammation and kidney injury in mice. HYP treatment significantly alleviated Cd-induced kidney injury by decreasing indexes of ...
Source: Food and Chemical Toxicology - January 7, 2023 Category: Food Science Authors: Ziyin Li Weizuo Liao Xinxin Yin Lili Liu Zhiqiang Zhao Xiaodan Lu Feifei Xu Xiuqin Lin Yingsi Chen Jia Song Zhini He Qinzhi Wei Weiliang Wu Yongning Wu Xingfen Yang Source Type: research

Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis
In conclusion, through mutual promotion between Lonp1 and Sig-1R, UA could effectively relieve OTA-induced apoptosis in vitro and break the vicious cycle between oxidative stress and ERS, which activated the mitochondrial apoptosis pathway.PMID:36587836 | DOI:10.1016/j.fct.2022.113592
Source: Food and Chemical Toxicology - January 1, 2023 Category: Food Science Authors: Qipeng Zhang Wenying Chen Boyang Zhang Yiwen Zhang Yuqing Xiao Yichen An Lingyun Han Huiqiong Deng Song Yao Hongwei Wang Xiao Li Shen Source Type: research

Stimulus-responsive hybrid nanoparticles based on multiple lipids for the co-delivery of doxorubicin and Sphk2-siRNA and breast cancer therapy
Food Chem Toxicol. 2022 Nov 28:113532. doi: 10.1016/j.fct.2022.113532. Online ahead of print.NO ABSTRACTPMID:36455683 | DOI:10.1016/j.fct.2022.113532
Source: Food and Chemical Toxicology - December 1, 2022 Category: Food Science Authors: Jinying Liang Shiqi Guo Mengxin Bai Mengying Huang Yupeng Qu Ying Zhao Yu Song Source Type: research

Cystine induced ‐mTORC2 activation through promoting Sin1 phosphorylation to suppress cancer cell ferroptosis
Conclusion: These results indicate that cystine-induced activation of the p38-Sin1-mTORC2-AKT pathway suppresses ferroptosis.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - October 3, 2022 Category: Food Science Authors: GuoYan Wang, Lei Chen, SenLin Qin, YiNing Zheng, Chao Xia, JunHu Yao, Ping Wang, Lu Deng Tags: Research Article Source Type: research

Fumonisin B < sub > 1 < /sub > induced intestinal epithelial barrier damage through endoplasmic reticulum stress triggered by the ceramide synthase 2 depletion
In this study, we found that FB1 inhibited cell viability, and promoted the severe release of lactate dehydrogenase. Meantime, FB1 destroyed the intestinal physical barrier by reducing the expressions of tight junctions. And FB1 induced excessive production of cytokines like tumor necrosis factor-α, resulting in damage to the intestinal immunological barrier. Furthermore, we observed that FB1 preferentially inhibited the expressions of ceramide synthase 2 (CerS2) and upregulated the expression of endoplasmic reticulum (ER) stress markers. The siRNA-mediated knockdown of CerS2 and CerS2 overexpression proved that CerS2 dep...
Source: Food and Chemical Toxicology - July 1, 2022 Category: Food Science Authors: Mengcong Li Shuhui Liu Lei Tan Yan Luo Zhangshan Gao Jiwen Liu Yuting Wu Wentao Fan Sarah DeSaeger Suquan Song Source Type: research

Deoxynivalenol enhances estrogen receptor alpha-induced signaling by ligand-independent transactivation
Food Chem Toxicol. 2022 May 16:113127. doi: 10.1016/j.fct.2022.113127. Online ahead of print.ABSTRACTDeoxynivalenol (DON), which is one of the prevalent mycotoxins in food and feeds, exerts adverse effects on animal and human health. These effects are mainly associated with its ribotoxic properties, although few studies suggest the involvement of other mechanisms of action. To assess the ability of DON to disrupt estrogen signaling, we conducted an in vitro study using MCF-7 and MDA-MB-231 cells. After 72h, DON reduced cell viability in both cell lines, thus highlighting its well-known cytotoxic effect. However, after 6h, ...
Source: Food and Chemical Toxicology - May 19, 2022 Category: Food Science Authors: M Drouault C Delalande H Boura ïma-Lelong V Seguin D Garon V Hanoux Source Type: research