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Total 76 results found since Jan 2013.

Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Abstract Inhibiting collagen generation is one effective method to treat liver fibrosis. Dioscin showed protective effect against liver fibrosis in our previous studies, and in the present work, SILAC-based proteomics was employed to test the underlying mechanism. A total of 121 differentially expressed proteins caused by dioscin in LX-2 cells were found, and dioscin significantly decreased the expression levels of FN, FAK1, ITGA5, p-PI3K/PI3K, p-Akt/Akt, p-mTOR/mTOR, Col1a1, Col1a2, Col2a1, Col5a1, Col6a1, and increased 2ABB level in vivo and in vitro. Thus, we elucidated that dioscin specifically suppressed col...
Source: Food and Chemical Toxicology - July 6, 2017 Category: Food Science Authors: Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J Tags: Food Chem Toxicol Source Type: research

Resveratrol contributes to chemosensitivity of malignant mesothelioma cells with activation of p53.
Abstract Resveratrol is a naturally occurring polyphenolic phytoalexin with chemopreventive properties. We previously reported a synergistic anti-proliferative effect of resveratrol and clofarabine against malignant mesothelioma (MM) cells. Here, we further investigated molecular mechanisms involved in the synergistic interaction of these compounds in MM MSTO-211H cells. Resveratrol, in combination with clofarabine, time-dependently induced a strong cytotoxic effect with the nuclear accumulation of phospho-p53 (p-p53) in MSTO-211H cells, but not in normal mesothelial MeT-5A cells. Combination treatment up-regulate...
Source: Food and Chemical Toxicology - November 14, 2013 Category: Food Science Authors: Lee YJ, Park IS, Lee YJ, Shim JH, Cho MK, Nam HS, Park JW, Oh MH, Lee SH Tags: Food Chem Toxicol Source Type: research

Oxyresveratrol stimulates mucin production in an NAD+-dependent manner in human intestinal goblet cells.
In conclusion, OXY increases NAD+ levels, resulting in the stimulation of MUC2 expression in LS 174T cells. These findings present a novel role for NAD+ in stimulation of MUC2 expression. PMID: 29935245 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - June 20, 2018 Category: Food Science Authors: Hwang D, Jo H, Ma SH, Lim YH Tags: Food Chem Toxicol Source Type: research

PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells.
In conclusion, CA appears to counteract the neurotoxicity of 6-OHDA by activating PINK1/parkin-mediated mitophagy. PMID: 30707903 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - January 29, 2019 Category: Food Science Authors: Lin CY, Tsai CW Tags: Food Chem Toxicol Source Type: research

Upregulation of OPA1 by carnosic acid is mediated through induction of IKK γ ubiquitination by parkin and protects against neurotoxicity.
In conclusion, the mechanism by which CA counteracts the toxicity of 6-OHDA is through modulation of mitochondrial dynamics and upregulation of OPA1 via activation of the parkin/IKKγ/p65 pathway. PMID: 31705926 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - November 5, 2019 Category: Food Science Authors: Lin CY, Chen WJ, Fu RH, Tsai CW Tags: Food Chem Toxicol Source Type: research

Epigallocatechin Gallate Induces Upregulation of LDL Receptor via the 67  kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.
Source: Molecular Nutrition and Food Research - February 5, 2020 Category: Food Science Authors: Kumiko Zanka, Yuya Kawaguchi, Yudai Okada, Satoshi Nagaoka Tags: Research Article Source Type: research

Organic Cation Transporter I and Na+/taurocholate Co ?Transporting Polypeptide are Involved in Retrorsine? and Senecionine?Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirm previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.
Source: Molecular Nutrition and Food Research - December 11, 2021 Category: Food Science Authors: Anne ?Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Ptz, Albert Braeuning, Stefanie Hessel?Pras Tags: Research Article Source Type: research

Deoxynivalenol enhances estrogen receptor alpha-induced signaling by ligand-independent transactivation
Food Chem Toxicol. 2022 May 16:113127. doi: 10.1016/j.fct.2022.113127. Online ahead of print.ABSTRACTDeoxynivalenol (DON), which is one of the prevalent mycotoxins in food and feeds, exerts adverse effects on animal and human health. These effects are mainly associated with its ribotoxic properties, although few studies suggest the involvement of other mechanisms of action. To assess the ability of DON to disrupt estrogen signaling, we conducted an in vitro study using MCF-7 and MDA-MB-231 cells. After 72h, DON reduced cell viability in both cell lines, thus highlighting its well-known cytotoxic effect. However, after 6h, ...
Source: Food and Chemical Toxicology - May 19, 2022 Category: Food Science Authors: M Drouault C Delalande H Boura ïma-Lelong V Seguin D Garon V Hanoux Source Type: research

γ-Tocotrienol induced cell cycle arrest and apoptosis via activating the Bax-mediated mitochondrial and AMPK signaling pathways in 3T3-L1 adipocytes.
This study aimed to examine the anti-proliferative effects of α-, γ- and δ-tocotrienols (αT3, γT3 and δT3), and α-tocopherol on 3T3-L1 adipocytes. Results showed that compared with other vitamin E analogues, γT3 demonstrated the most potent anti-proliferative effect on 3T3-L1 cells. It significantly caused a reduction in mitochondrial membrane potential (Δψm) and an increase in ROS formation, as well as inducing cell apoptosis and cell cycle arrest at S phase. Further studies showed that it down-regulated Bcl-2 and PPAR-γ expression, suppressed Akt and ERK activation and phosphorylation, and caused cytochrome c ...
Source: Food and Chemical Toxicology - June 28, 2013 Category: Food Science Authors: Wu SJ, Huang GY, Ng LT Tags: Food Chem Toxicol Source Type: research

Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress.
Abstract Prolonged endoplasmic reticulum (ER) stress may activate apoptotic pathways in cancer cells. It is suggested that ER stress has the potential of enhancing tumor death in cancer therapy. Galangin, a flavonol derived from Alpinia officinarum Hance, has been shown to suppress the proliferation of hepatocellular carcinoma cells (HCC). The aim of this study was to determine whether galangin was able to induce ER stress in HepG2, Hep3B and PLC/PRF/5 cells. The proliferation of HCC was tested by MTT method. Intracellular Ca(2+) levels were measured with Fluo3-AM.The proteins levels of GRP94, GRP78 and CHOP were ...
Source: Food and Chemical Toxicology - October 22, 2013 Category: Food Science Authors: Su L, Chen X, Wu J, Lin B, Zhang H, Lan L, Luo H Tags: Food Chem Toxicol Source Type: research

Rubus idaeus L. Reverses Epithelial-to-Mesenchymal Transition and Suppresses Cell Invasion and Protease Activities by Targeting ERK1/2 and FAK Pathways in Human Lung Cancer Cells.
Abstract Epithelial to mesenchymal transition (EMT) has been considered essential for cancer metastasis, a multistep complicated process including local invasion, intravasation, extravasation, and proliferation at distant sites. Herein we provided molecular evidence associated with the antimetastatic effect of Rubus idaeus L. extracts (RIE) by showing a nearly complete inhibition on the invasion (p < 0.001) of highly metastatic A549 cells via reduced activities of matrix metalloproteinase-2 (MMP-2) and urokinasetype plasminogen activator (u-PA). We performed Western blot to find that RIE could induce up-regulat...
Source: Food and Chemical Toxicology - October 23, 2013 Category: Food Science Authors: Hsieh YS, Chu SC, Hsu LS, Chen KS, Lai MT, Yeh CH, Chen PN Tags: Food Chem Toxicol Source Type: research

Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling.
Abstract Icaritin is the major active ingredient of Herba Epimedii. Icaritin (ICT) is a hydrolytic product of Icariin. In the present study, we investigated the protective role of ICT against cigarette smoke extract (CSE)-mediated oxidative stress in human lung epithelial A549 cells. As demonstrated by the WST-8 assay, exposure to CSE (2.5%, 5%, and 10%) reduced the cell viability of A549 cells (84%, 64% and 53%) in a dose-dependent manner and treatment with ICT 10μM dramatically attenuated CSE induced cytotoxicity (73% and 64%). The MFI data suggested that CSE induced oxidative stress by generating ROS (230) and...
Source: Food and Chemical Toxicology - December 8, 2013 Category: Food Science Authors: Wu J, Xu H, Wong PF, Xia S, Xu J, Dong J Tags: Food Chem Toxicol Source Type: research

α-Mangostin-induced apoptosis is mediated by estrogen receptor α in human breast cancer cells.
In this study, we evaluated the effects of α-mangostin on cell growth inhibition and induction of apoptosis in MCF-7 ERα-positive human breast cancer cells. Our results showed that α-mangostin inhibited MCF-7 cell proliferation whereas ERα-negative MDA-MB-231 cells were less sensitive to the agent. Additionally, α-mangostin effectively induced apoptosis as evidenced by the appearance of apoptotic nuclei observed with Hoechst 33258 staining and evaluation of sub-G1 DNA contents by flow cytometry. α-Mangostin also activated caspases-8, -9, and -7; increased the protein levels of Bax, p53, and cytosolic cytochrome c; an...
Source: Food and Chemical Toxicology - January 28, 2014 Category: Food Science Authors: Won YS, Lee JH, Kwon SJ, Kim JY, Park KH, Lee MK, Seo KI Tags: Food Chem Toxicol Source Type: research

Modulation of Atg5 Expression by Globular Adiponectin Contributes to Autophagy Flux and Suppression of Ethanol-Induced Cell Death in Liver Cells.
Abstract Globular adiponectin (gAcrp) protects liver cells from ethanol-induced apoptosis via induction of autophagy. However, the underlying mechanisms are unknown. The present study aims to investigate the potential role of autophagy-related protein 5 (Atg5), an essential Atg for the elongation of autophagosomes, in suppression of ethanol-induced cytotoxicity by gAcrp. Here, we demonstrated that suppression of Atg5 expression by ethanol was restored by pretreatment with gAcrp both in primary rat hepatocytes and human hepatoma cell line (HepG2). Moreover, ethanol-induced accumulation of p62 (sequestosome1), a mar...
Source: Food and Chemical Toxicology - February 26, 2014 Category: Food Science Authors: Nepal S, Kim MJ, Lee ES, Kim JA, Choi DY, Sohn DH, Lee SH, Song K, Kim SH, Jeong GS, Jeong TC, Park PH Tags: Food Chem Toxicol Source Type: research