Filtered By:
Specialty: Food Science

This page shows you your search results in order of relevance. This is page number 2.

Order by Relevance | Date

Total 76 results found since Jan 2013.

Chk1, but not Chk2, is responsible for G2/M phase arrest induced by diallyl disulfide in human gastric cancer BGC823 cells.
Abstract Diallyl disulfide (DADS) has been shown to cause G2/M phase cell cycle arrest in several human cancers. Here we demonstrate a mechanism by which DADS induces G2/M phase arrest in BGC823 human gastric cancer cells via Chk1. From cell cycle gene array results, we next confirmed that cyclin B1 expression was decreased by DADS, while the expression of p21, GADD45α and p53 were increased. Despite the lack of change in Chk1 gene expression in response to DADS according to the array analysis, intriguingly overexpression of Chk1, but not Chk2, exhibited increased accumulation in G2/M phase. Moreover, overexpress...
Source: Food and Chemical Toxicology - March 17, 2014 Category: Food Science Authors: Bo S, Hui H, Li W, Hui L, Hong X, Lin D, Wen-Xiang D, You-Hua W, Xiao-Hong A, Hao J, Qi S Tags: Food Chem Toxicol Source Type: research

Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line.
In this study we investigate the role of salmon (Salmo salar) and king crab trypsin (Paralithodes camtschaticus) as inducers of inflammation in skin via secretion of inflammatory mediators. Human skin keratinocytes (HaCaT cells) were exposed to purified salmon and king crab trypsin. We observed that salmon trypsin enhanced the secretion of IL-8 and MMP-2 and crab trypsin enhanced the secretion of IL-8, MMP-2 and MMP-9 in a dose dependent manner. As protease activated receptors (PAR)-2 in skin are known to play an important role in physiology and pathology, we explored the involvement of in mediating the release of interleu...
Source: Food and Chemical Toxicology - April 29, 2014 Category: Food Science Authors: Bhagwat SS, Larsen AK, Winberg JO, Seternes OM, Bang B Tags: Food Chem Toxicol Source Type: research

Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways
Conclusion: These results suggest that sulforaphane has the potential to prevent cardiac hypertrophy by down‐regulating GATA4/6 and MAPK signaling pathways.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - October 1, 2014 Category: Food Science Authors: Hae Jin Kee, Gwi Ran Kim, In Kyeom Kim, Myung Ho Jeong Tags: Research Article Source Type: research

Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function
Conclusion: Nobiletin exerted anti‐inflammatory effects in TNBS‐induced colitis through the down‐regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX‐2) expression. Nobiletin restored barrier function, which had been damaged after TNBS administration, through the inhibition of the Akt–NF‐κB–MLCK pathway.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - February 1, 2015 Category: Food Science Authors: Yongjian Xiong, Dapeng Chen, Changchun Yu, Bochao Lv, Jinyong Peng, Jingyu Wang, Yuan Lin Tags: Research Article Source Type: research

Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway
Conclusions: RSV improved hepatic steatosis partially by inducing autophagy in vitro and in vivo, via the cAMP‐PRKA‐AMPK‐SIRT1 signaling pathway, which provides new evidence regarding RSV's effects on NAFLD treatmentThis article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - May 5, 2015 Category: Food Science Authors: Yong Zhang, Ming‐liang Chen, Yong Zhou, Long Yi, Yan‐xiang Gao, Li Ran, Shi‐hui Chen, Ting Zhang, Xi Zhou, Dan Zou, Bin Wu, Ying Wu, Hui Chang, Jun‐dong Zhu, Qian‐yong Zhang, Man‐tian Mi Tags: Research Article Source Type: research

Curcumin protects against fructose‐induced podocyte insulin signaling impairment through upregulation of miR‐206
ConclusionCurcumin is suggested to activate miR‐206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose‐induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin's effects on fructose‐associated podocyte injury.
Source: Molecular Nutrition and Food Research - October 15, 2015 Category: Food Science Authors: Xiao‐Qin Ding, Ting‐Ting Gu, Wei Wang, Lin Song, Tian‐Yu Chen, Qiao‐Chu Xue, Fan Zhou, Jian‐Mei Li, Ling‐Dong Kong Tags: Research Article Source Type: research

P21 (Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
In conclusion, these findings demonstrated that p21 plays a critical role in FZD-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. PMID: 26687534 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - December 10, 2015 Category: Food Science Authors: Deng S, Tang S, Dai C, Zhou Y, Yang X, Li D, Xiao X Tags: Food Chem Toxicol Source Type: research

Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats
Conclusion: CA exerted protective effects against alcoholic liver injury by activating the SIRT1/ChREBP and SIRT1/p66shc pathways, which are related to the anti‐steatosis, anti‐oxidant and anti‐apoptosis effects.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - March 31, 2016 Category: Food Science Authors: Lili Gao, Wen Shan, Wenjing Zeng, Yan Hu, Guangzhi Wang, Xiaofeng Tian, Ning Zhang, Xue Shi, Yan Zhao, Chunchun Ding, Feng Zhang, Kexin Liu, Jihong Yao Tags: Research Article Source Type: research

2,3,4',5-tetrahydroxystilbene-2-O- β-D-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-κB and activating AMPK/Nrf2 pathways.
In conclusion, we demonstrated that THSG attenuates the LPS-induced neuroinflammatory response mediated by AMPK/Nrf2 signaling pathways. PMID: 27621050 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - September 8, 2016 Category: Food Science Authors: Park SY, Jin ML, Wang Z, Park G, Choi YW Tags: Food Chem Toxicol Source Type: research

Fructose down ‐regulates miR‐330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin
Conclusion: These findings suggest that morin protects against fructose‐induced kidney insulin signaling impairment by up‐regulating miR‐330 to reduce inflammatory response. Morin may be a potential therapeutic agent for the treatment of kidney injury associated with fructose‐induced inflammation and insulin signaling impairment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 31, 2017 Category: Food Science Authors: Ting ‐Ting Gu, Lin Song, Tian‐Yu Chen, Xin Wang, Xiao‐Juan Zhao, Xiao‐Qin Ding, Yan‐Zi Yang, Ying Pan, Dong‐Mei Zhang, Ling‐Dong Kong Tags: Research Article Source Type: research

Inhibition of JNK by pi class of glutathione S-transferase through PKA/CREB pathway is associated with carnosic acid protection against 6-hydroxydopamine-induced apoptosis.
CONCLUSION: CA prevents 6-OHDA-induced apoptosis via inhibition of JNK by GSTP through the PKA/CREB pathway. PMID: 28288932 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - March 9, 2017 Category: Food Science Authors: Lin CY, Fu RH, Chou RH, Chen JH, Wu CR, Chang SW, Tsai CW Tags: Food Chem Toxicol Source Type: research

The anti ‐inflammatory effects of Morin hydrate in atherosclerosis is associated with autophagy induction through cAMP signaling
Conclusion: Our results suggest that anti‐AS and anti‐inflammatory effects of MO are largely associated with its induction of autophagy through stimulation of cAMP‐PKA‐AMPK‐SIRT1 signaling pathway.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - April 1, 2017 Category: Food Science Authors: Yue Zhou, Zhan ‐Qi Cao, Hong‐Yuan Wang, Yan‐Na Cheng, Lu‐Gang Yu, Xin‐Ke Zhang, Yan Sun, Xiu‐Li Guo Tags: Research Article Source Type: research

Dual-Targeting Multifuntional Mesoporous Silica Nanocarrier for Codelivery of siRNA and Ursolic Acid to Folate Receptor Overexpressing Cancer Cells
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.7b03047
Source: Journal of Agricultural and Food Chemistry - August 3, 2017 Category: Food Science Authors: Guirong Zheng, Yiling Shen, Ruirui Zhao, Fan Chen, Ying Zhang, Aixiao Xu and Jingwei Shao Source Type: research

Essential roles of Akt/Snail pathway in microcystin-LR-induced tight junction toxicity in Sertoli cell.
Abstract Microcystin (MC)-LR is a cyclic heptapeptide that acts as a potent reproductive system toxin. However, the underlying pathways of MCLR-induced reproductive system toxicity have not been well elucidated. The blood-testis barrier is mainly constituted by tight junctions (TJs) between adjacent Sertoli cells in the seminiferous epithelium near the basement membrane. The present study was designed to investigate changes in TJs and the underlying pathway in MC-LR-induced TJs toxicity in Sertoli cell. In our study, the transepithelial electrical resistance (TER) value was decreased in a dose dependent manner due...
Source: Food and Chemical Toxicology - January 4, 2018 Category: Food Science Authors: Zhou Y, Geng X, Chen Y, Shi H, Yang Y, Zhu C, Yu G, Tang Z Tags: Food Chem Toxicol Source Type: research

TGF- β1 acts as mediator in fluoride-induced autophagy in the mouse osteoblast cells.
TGF-β1 acts as mediator in fluoride-induced autophagy in the mouse osteoblast cells. Food Chem Toxicol. 2018 Mar 02;: Authors: Zhao Y, Li Y, Gao Y, Yuan M, Manthari RK, Wang J, Wang J Abstract It is well known that excess fluoride intake can result in fluorosis, which is a serious public health problem. TGF-β1 affects a wide variety of cellular activities and plays an important role in fluorosis. Recent literature proved that fluoride induces autophagy, however, the mechanism is still unclear, and the role of TGF-β1 in the fluoride-induced autophagy should be further illustrated. Therefore, in this...
Source: Food and Chemical Toxicology - March 2, 2018 Category: Food Science Authors: Zhao Y, Li Y, Gao Y, Yuan M, Manthari RK, Wang J, Wang J Tags: Food Chem Toxicol Source Type: research