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Total 76 results found since Jan 2013.

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
In conclusion, the results demonstrated that the molecular mechanisms of quercetin in regulating apoptosis and autophagy-related pathways and increasing GEM chemosensitivity in pancreatic cancer cells involved inhibition of RAGE expression.Graphical abstractThis diagram illustrated that quercetin treatment effectively attenuated RAGE expression to facilitate autophagy, apoptosis, and GEM chemosensitivity in MIA Paca-2 and MIA Paca-2 GEMR cells.
Source: Journal of Food and Drug Analysis - August 22, 2019 Category: Food Science Source Type: research

Punicalagin, a Pomegranate ‐Derived Ellagitannin, Suppresses Obesity and Obesity‐Induced Inflammatory Responses Via the Nrf2/Keap1 Signaling Pathway
ConclusionsPCG ameliorated obesity and obesity ‐induced inflammatory responses via activation of Nrf2/Keap1 signaling, suggesting that PCG has potential as an oral agent to control obesity‐mediated diseases.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - August 23, 2019 Category: Food Science Authors: Bobin Kang, Chae Young Kim, Jisu Hwang, Kyungae Jo, Singeun Kim, Hyung Joo Suh, Hyeon ‐Son Choi Tags: Research Article Source Type: research

The curcumin analogue WZ35 affects glycolysis inhibition of gastric cancer cells through ROS-YAP-JNK pathway.
Abstract To investigate the anti-tumor activities of WZ35 and its possible molecular mechanism, bioinformatics analysis and the hematoxylin-eosin (HE) staining were applied to evaluate the Yes-associated-protein (YAP) level in gastric cancer. Cell counting kit-8 (CCK-8) was used to examine cell viability. Apoptosis was determined by flow cytometry analysis. Seahorse bioenergetics analyzer was used to investigate the alteration of oxygen consumption and aerobic glycolysis rate. SiRNA transfection was applied to silence endogenous YAP. Western blot was performed to detect indicated proteins. We found that treatment ...
Source: Food and Chemical Toxicology - January 16, 2020 Category: Food Science Authors: Chen T, Zhao L, Chen S, Zheng B, Chen H, Zeng T, Sun H, Zhong S, Wu W, Lin X, Wang L Tags: Food Chem Toxicol Source Type: research

Epigallocatechin Gallate Induces Up ‐Regulation of LDL Receptor via the 67 kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Kumiko Zanka, Yuya Kawaguchi, Yudai Okada, Satoshi Nagaoka Tags: Research Article Source Type: research

Gut metabolite, Urolithin A decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUrolithin A leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary Urolithin A in cancer prevention or as adjuvant therapy is promising.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch1, Madhuri S Salker Tags: Research Article Source Type: research

Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin, Toshiyuki Okumura, Janet Rajaxavier, Shayan Khozooei, Simone P öschel, Satoru Takeda, Yogesh Singh, Sara Y Brucker, Diethelm Wallwiener, André Koch, Madhuri S Salker Tags: Research Article Source Type: research

Improved Glucose Intolerance Through a Distinct Mouse Olfactory Receptor 23 ‐Induced Signaling Pathway Mediating Glucose Uptake In Myotubes and Adipocytes
ConclusionsThese findings suggest that MOR23 is a novel factor for the regulation of glucose uptake and whole ‐body glucose homeostasis and has therapeutic potential for diabetes treatment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - September 10, 2020 Category: Food Science Authors: Wesuk Kang, Kelun Zhang, Tao Tong, Taesun Park Tags: Research Article Source Type: research

IRE1 and CaMKK β pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells.
This study is the first study revealing the molecular mechanisms of MC-LR-induced autophagy of ovarian cells and providing new insights into the female reproductive toxicity of MC-LR. PMID: 33290805 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - December 5, 2020 Category: Food Science Authors: Ma Y, Liu H, Du X, Petlulu P, Chen X, Wang R, Zhang S, Tian Z, Shi L, Guo H, Zhang H Tags: Food Chem Toxicol Source Type: research

Targeting HMGB1 inhibits T-2 toxin-induced neurotoxicity via regulation of oxidative stress, neuroinflammation and neuronal apoptosis
Food Chem Toxicol. 2021 Mar 21:112134. doi: 10.1016/j.fct.2021.112134. Online ahead of print.ABSTRACTT-2 toxin, a food-derived mycotoxin, has been identified as a neurotoxin. Nonetheless, T-2 toxin-induced neuroinflammation has never been revealed. As an important therapeutic target for inflammatory diseases and cancers, the role of high mobility group B1 (HMGB1) in mycotoxin-mediated neurotoxicity remains a mystery. In current study, we found that PC12 cells were sensitive to trace amounts of T-2 toxin less than 12 ng/mL, distinguished by decreased cell viability and increased release of lactate dehydrogenase (LDH). Oxida...
Source: Food and Chemical Toxicology - March 25, 2021 Category: Food Science Authors: Xingyao Pei Haiyang Jiang Xinyu Liu Liuan Li Cun Li Xilong Xiao Daowen Li Shusheng Tang Source Type: research

Perfluorooctane sulfonate induces autophagy-dependent lysosomal membrane permeabilization by weakened interaction between tyrosinated alpha-tubulin and spinster 1
This study pointed out that SPNS1-tyrosinated α-tubulin interaction mediated the cross-talk between autophagy and LMP induced by PFOS, shedding new light on the mechanism of PFOS hepatotoxicity.PMID:34500008 | DOI:10.1016/j.fct.2021.112540
Source: Food and Chemical Toxicology - September 9, 2021 Category: Food Science Authors: Zhanchen Dong Tianming Qiu Jingyuan Zhang Shanshan Sha Xiuyan Han Jian Kang Xiaoxia Shi Xiance Sun Liping Jiang Guang Yang Xiaofeng Yao Yufang Ma Source Type: research

Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3 β/β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231
Food Chem Toxicol. 2021 Sep 15:112574. doi: 10.1016/j.fct.2021.112574. Online ahead of print.ABSTRACTGolgi Membrane Protein 1 (GOLM1) has been identified as a prime target for cancer therapy because it overexpresses in many solid tumors, increases tumor growth and metastasis and leads to unfavorable survival. Though various approaches including siRNA interference and antibody targeting have been attempted, GOLM1 has remained an un-targetable molecule because of its mainly intracellular location and the lack of domains that could possibly be interfered with by small molecules. Numerous natural anti-tumoral plant substances ...
Source: Food and Chemical Toxicology - September 18, 2021 Category: Food Science Authors: Ling Xie Jun Yi Yongjia Song Mengyao Zhao Liqiang Fan Liming Zhao Source Type: research

Organic Cation Transporter I and Na+/taurocholate Co ‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirmed previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - November 26, 2021 Category: Food Science Authors: Anne ‐Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning, Stefanie Hessel‐Pras Tags: Research Article Source Type: research

Chaperon-mediated autophagy can regulate diquat-induced apoptosis by inhibiting α-synuclein accumulation cooperatively with macroautophagy
In this study, we explored the role of CMA in diquat (DQ)-induced α-synucleinopathy and characterized the relationship between CMA and macroautophagy in the clearance of pathologic α-synuclein for the prevention of DQ neurotoxicity. DQ was cytotoxic to SH-SY5Y cells in a concentration-dependent manner, as shown by decreased cell viability and increased cytotoxicity. DQ treatment was also found to induce autophagy such as CMA and macroautophagy by monitoring the expression of Lamp2A and microtubule-associated protein 1A/1B light chain 3B (LC3-II) respectively. Following DQ treatment, SH-SY5Y cells were found to have induc...
Source: Food and Chemical Toxicology - December 1, 2021 Category: Food Science Authors: Hong Ju Kim Hyun Chul Koh Source Type: research