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Total 76 results found since Jan 2013.
Deoxynivalenol enhances estrogen receptor alpha-induced signaling by ligand-independent transactivation
Food Chem Toxicol. 2022 May 16:113127. doi: 10.1016/j.fct.2022.113127. Online ahead of print.ABSTRACTDeoxynivalenol (DON), which is one of the prevalent mycotoxins in food and feeds, exerts adverse effects on animal and human health. These effects are mainly associated with its ribotoxic properties, although few studies suggest the involvement of other mechanisms of action. To assess the ability of DON to disrupt estrogen signaling, we conducted an in vitro study using MCF-7 and MDA-MB-231 cells. After 72h, DON reduced cell viability in both cell lines, thus highlighting its well-known cytotoxic effect. However, after 6h, ...
Source: Food and Chemical Toxicology - May 19, 2022 Category: Food Science Authors: M Drouault C Delalande H Boura ïma-Lelong V Seguin D Garon V Hanoux Source Type: research
MYO ‐Inositol In Fermented Sugar Matrix Improves Human Macrophage Function
ConclusionThese observations indicate thatmyo-inositol in FPP influences multiple aspects of macrophage function critical for host defense against invading pathogens.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 24, 2022 Category: Food Science Authors: Nandini Ghosh,
Amitava Das,
Nirupam Biswas,
Sanskruti P. Mahajan,
Amit K. Madeshiya,
Savita Khanna,
Chandan K. Sen,
Sashwati Roy Tags: Research Article Source Type: research
Organic Cation Transporter I and Na+/taurocholate Co ?Transporting Polypeptide are Involved in Retrorsine? and Senecionine?Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirm previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.
Source: Molecular Nutrition and Food Research - December 11, 2021 Category: Food Science Authors: Anne ?Margarethe Enge,
Florian Kaltner,
Christoph Gottschalk,
Angelina Kin,
Michael Kirstgen,
Joachim Geyer,
Anja These,
Helen Hammer,
Oliver Ptz,
Albert Braeuning,
Stefanie Hessel?Pras Tags: Research Article Source Type: research
Chaperon-mediated autophagy can regulate diquat-induced apoptosis by inhibiting α-synuclein accumulation cooperatively with macroautophagy
In this study, we explored the role of CMA in diquat (DQ)-induced α-synucleinopathy and characterized the relationship between CMA and macroautophagy in the clearance of pathologic α-synuclein for the prevention of DQ neurotoxicity. DQ was cytotoxic to SH-SY5Y cells in a concentration-dependent manner, as shown by decreased cell viability and increased cytotoxicity. DQ treatment was also found to induce autophagy such as CMA and macroautophagy by monitoring the expression of Lamp2A and microtubule-associated protein 1A/1B light chain 3B (LC3-II) respectively. Following DQ treatment, SH-SY5Y cells were found to have induc...
Source: Food and Chemical Toxicology - December 1, 2021 Category: Food Science Authors: Hong Ju Kim Hyun Chul Koh Source Type: research
Organic Cation Transporter I and Na+/taurocholate Co ‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells
ConclusionOur results confirmed previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - November 26, 2021 Category: Food Science Authors: Anne ‐Margarethe Enge,
Florian Kaltner,
Christoph Gottschalk,
Angelina Kin,
Michael Kirstgen,
Joachim Geyer,
Anja These,
Helen Hammer,
Oliver Pötz,
Albert Braeuning,
Stefanie Hessel‐Pras Tags: Research Article Source Type: research
Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3 β/β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231
Food Chem Toxicol. 2021 Sep 15:112574. doi: 10.1016/j.fct.2021.112574. Online ahead of print.ABSTRACTGolgi Membrane Protein 1 (GOLM1) has been identified as a prime target for cancer therapy because it overexpresses in many solid tumors, increases tumor growth and metastasis and leads to unfavorable survival. Though various approaches including siRNA interference and antibody targeting have been attempted, GOLM1 has remained an un-targetable molecule because of its mainly intracellular location and the lack of domains that could possibly be interfered with by small molecules. Numerous natural anti-tumoral plant substances ...
Source: Food and Chemical Toxicology - September 18, 2021 Category: Food Science Authors: Ling Xie Jun Yi Yongjia Song Mengyao Zhao Liqiang Fan Liming Zhao Source Type: research
Perfluorooctane sulfonate induces autophagy-dependent lysosomal membrane permeabilization by weakened interaction between tyrosinated alpha-tubulin and spinster 1
This study pointed out that SPNS1-tyrosinated α-tubulin interaction mediated the cross-talk between autophagy and LMP induced by PFOS, shedding new light on the mechanism of PFOS hepatotoxicity.PMID:34500008 | DOI:10.1016/j.fct.2021.112540
Source: Food and Chemical Toxicology - September 9, 2021 Category: Food Science Authors: Zhanchen Dong Tianming Qiu Jingyuan Zhang Shanshan Sha Xiuyan Han Jian Kang Xiaoxia Shi Xiance Sun Liping Jiang Guang Yang Xiaofeng Yao Yufang Ma Source Type: research
Targeting HMGB1 inhibits T-2 toxin-induced neurotoxicity via regulation of oxidative stress, neuroinflammation and neuronal apoptosis
Food Chem Toxicol. 2021 Mar 21:112134. doi: 10.1016/j.fct.2021.112134. Online ahead of print.ABSTRACTT-2 toxin, a food-derived mycotoxin, has been identified as a neurotoxin. Nonetheless, T-2 toxin-induced neuroinflammation has never been revealed. As an important therapeutic target for inflammatory diseases and cancers, the role of high mobility group B1 (HMGB1) in mycotoxin-mediated neurotoxicity remains a mystery. In current study, we found that PC12 cells were sensitive to trace amounts of T-2 toxin less than 12 ng/mL, distinguished by decreased cell viability and increased release of lactate dehydrogenase (LDH). Oxida...
Source: Food and Chemical Toxicology - March 25, 2021 Category: Food Science Authors: Xingyao Pei Haiyang Jiang Xinyu Liu Liuan Li Cun Li Xilong Xiao Daowen Li Shusheng Tang Source Type: research
IRE1 and CaMKK β pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells.
This study is the first study revealing the molecular mechanisms of MC-LR-induced autophagy of ovarian cells and providing new insights into the female reproductive toxicity of MC-LR.
PMID: 33290805 [PubMed - as supplied by publisher]
Source: Food and Chemical Toxicology - December 5, 2020 Category: Food Science Authors: Ma Y, Liu H, Du X, Petlulu P, Chen X, Wang R, Zhang S, Tian Z, Shi L, Guo H, Zhang H Tags: Food Chem Toxicol Source Type: research
Improved Glucose Intolerance Through a Distinct Mouse Olfactory Receptor 23 ‐Induced Signaling Pathway Mediating Glucose Uptake In Myotubes and Adipocytes
ConclusionsThese findings suggest that MOR23 is a novel factor for the regulation of glucose uptake and whole ‐body glucose homeostasis and has therapeutic potential for diabetes treatment.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - September 10, 2020 Category: Food Science Authors: Wesuk Kang,
Kelun Zhang,
Tao Tong,
Taesun Park Tags: Research Article Source Type: research
Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin,
Toshiyuki Okumura,
Janet Rajaxavier,
Shayan Khozooei,
Simone P öschel,
Satoru Takeda,
Yogesh Singh,
Sara Y Brucker,
Diethelm Wallwiener,
André Koch,
Madhuri S Salker Tags: Research Article Source Type: research
Epigallocatechin Gallate Induces Upregulation of LDL Receptor via the 67 kDa Laminin Receptor‐Independent Pathway in HepG2 Cells
ConclusionEGCG activates LDLR expression via 67LR ‐independent pathway in HepG2 cells.
Source: Molecular Nutrition and Food Research - February 5, 2020 Category: Food Science Authors: Kumiko Zanka,
Yuya Kawaguchi,
Yudai Okada,
Satoshi Nagaoka Tags: Research Article Source Type: research
