Perfluorooctane sulfonate induces autophagy-dependent lysosomal membrane permeabilization by weakened interaction between tyrosinated alpha-tubulin and spinster 1

This study pointed out that SPNS1-tyrosinated α-tubulin interaction mediated the cross-talk between autophagy and LMP induced by PFOS, shedding new light on the mechanism of PFOS hepatotoxicity.PMID:34500008 | DOI:10.1016/j.fct.2021.112540

Source: Food and Chemical Toxicology - September 9, 2021 Category: Food Science Authors: Zhanchen Dong Tianming Qiu Jingyuan Zhang Shanshan Sha Xiuyan Han Jian Kang Xiaoxia Shi Xiance Sun Liping Jiang Guang Yang Xiaofeng Yao Yufang Ma Source Type: research