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Total 47 results found since Jan 2013.

In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier.
In this report, the biodistribution in mice of siRNA loaded dextran nanogels was investigated in detail. Both single photon emission computed tomography (SPECT) imaging and fluorescence single particle tracking (fSPT) indicate that the particles are rapidly cleared from the circulation. PEGylation of the nanogels was not able to increase the half-life in the bloodstream. Carrier disassembly in the systemic circulation and phagocytic clearance are known to facilitate the elimination of siRNA nanoparticles. Additionally, it is demonstrated for dextran nanogels that also the kidneys play an important role in their elimination...
Source: Biomaterials - December 19, 2012 Category: Materials Science Authors: Naeye B, Deschout H, Caveliers V, Descamps B, Braeckmans K, Vanhove C, Demeester J, Lahoutte T, De Smedt SC, Raemdonck K Tags: Biomaterials Source Type: research

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice
Conclusions: EMF-guided 131I-hVEGF siRNA/SilenceMag exhibited an antitumor effect. The synergic therapy of 131I-hVEGF siRNA/SilenceMag might be a promising future treatment option against HCC with the dual functional properties of tumor therapy and imaging.
Source: BMC Cancer - February 21, 2014 Category: Cancer & Oncology Authors: Jing ChenShu ZhuLiangqian TongJiansha LiFei ChenYunfeng HanMing ZhaoWei Xiong Source Type: research

Preliminary evaluation of a small interfering RNA molecular probe targeting murine double minute 2 in breast cancer
CONCLUSION: The [99mTc]HYNIC-siRNA 1489 was taken up by the tumor, which had a high level of MDM2. The probe exhibited a sufficient retention time in the tumor. This probe may be an effective strategy for evaluating MDM2 expression and achieving early diagnosis in breast cancer.PMID:35582848 | DOI:10.1097/MNM.0000000000001582
Source: Cancer Control - May 18, 2022 Category: Cancer & Oncology Authors: Xinyu Wang Peng Xu Yuying Jiao Sha Luan Yue Gao Changjiu Zhao Peng Fu Source Type: research

CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and Th17 response.
Abstract The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CARD11-targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3d after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and micro-computed tomography (mic...
Source: Clinical and Developmental Immunology - January 20, 2014 Category: Allergy & Immunology Authors: Wang H, Zhao J, Zhang H, Huang Y, Wang S, Tu Q, Yang N Tags: Clin Exp Immunol Source Type: research

CARD11 blockade suppresses murine collagen‐induced arthritis via inhibiting CARD11/Bcl10 assembly and Th17 response
Summary The scaffold protein caspase recruitment domain‐containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen‐induced arthritis (CIA) were treated with either CARD11‐targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3d after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and micro‐computed tomography (micro...
Source: Clinical and Experimental Immunology - January 21, 2014 Category: Allergy & Immunology Authors: Hongyue Wang, Jijun Zhao, Hui Zhang, Yuefang Huang, Shuang Wang, Qingqiang Tu, Niansheng Yang Tags: Original Article Source Type: research

Amelioration of Posttraumatic Osteoarthritis in Mice Using Intraarticular Silencing of Periostin via Nanoparticle ‐Based Small Interfering RNA
ConclusionIA delivery of the periostin –siRNA nanocomplex represents a promising clinical approach to mitigate the severity of joint degeneration in OA. Our findings may thus provide an unequivocal scientific rationale for longitudinal studies of this approach. Utilizing a cartilage-specific gene-knockout strategy will further illumina te the functional role of periostin in OA.
Source: Arthritis and Rheumatology - October 28, 2021 Category: Rheumatology Authors: Xin Duan, Lei Cai, Christine T. N. Pham, Yousef Abu ‐Amer, Hua Pan, Robert H. Brophy, Samuel A. Wickline, Muhammad Farooq Rai Tags: Full Length Source Type: research

The Role of Thrombin Deficiency on Skeletal Health
ConclusionThis study seeks to understand the underlying mechanism for bone disease in hemophilia. The results indicate that >85% prothrombin knockdown in wild-type mice starting at 3 weeks of age does not significantly alter skeletal health. This suggests that either 1) thrombin deficiency is not involved in the mechanism of decreased skeletal health in hemophilia or; 2) the role of thrombin deficiency occurs early in bone development (prior to 3 weeks of age). To evaluate these two potential explanations, thrombin deficiency needs to be evaluated earlier in development. Thrombin deficient mice are embryonically lethal....
Source: Blood - November 21, 2018 Category: Hematology Authors: Taylor, H. J., Goldscheitter, G., Taylor, J. A. Tags: 321. Blood Coagulation and Fibrinolytic Factors Source Type: research

Targeted Combination of Antioxidative and Anti ‐Inflammatory Therapy of Rheumatoid Arthritis using Multifunctional Dendrimer‐Entrapped Gold Nanoparticles as a Platform
A multifunctional dendrimer nanoplatform is developed to have entrapped gold nanoparticles within dendrimer interiors, and covalently linked PEGylated alpha ‐tocopheryl succinate, PEGylated folic acid, and 1,3‐propane sultone on dendrimer peripheries. The designed nanoplatform enables co‐delivery of drug/gene to macrophage cells, effectively scavenging reactive oxygen species and inhibiting tumor necrosis factor‐α expression for combined antiox idative and anti‐inflammatory therapy of rheumatoid arthritis. AbstractAbundant reactive oxygen species and tumor necrosis factor ‐α (TNF‐α) cytokine supply of M1...
Source: Small - November 17, 2020 Category: Nanotechnology Authors: Jin Li, Liang Chen, Xiaoying Xu, Yu Fan, Xue Xue, Mingwu Shen, Xiangyang Shi Tags: Full Paper Source Type: research

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing
ObjectivesThe aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post–myocardial infarction (MI) remodeling.BackgroundIn healing wounds, the M1 toward M2 macrophage phenotype transition supports resolution of inflammation and tissue repair. Persistence of inflammatory M1 macrophages may derail healing and compromise organ functions. The transcription factor IRF5 up-regulates genes associated with M1 macrophages.MethodsHere we used nanoparticle-delivered small interfering ribonucleic acid (siRNA) ...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - April 14, 2014 Category: Radiology Source Type: research

The Discoidin Domain Receptor 2/Annexin A2/Matrix Metalloproteinase 13 Loop Promotes Joint Destruction in Arthritis Through Promoting Migration and Invasion of Fibroblast‐like Synoviocytes
ConclusionAnnexin A2 is a key molecule in the DDR‐2/annexin A2/MMP‐13 loop, the activation of which contributes to joint destruction in RA, mainly through promoting invasion of FLS. Annexin A2 might therefore become a novel clinical target for RA treatment.
Source: Arthritis and Rheumatism - August 26, 2014 Category: Rheumatology Authors: Wei Zhao, Cun Zhang, Man Shi, Jian Zhang, Meng Li, Xiaochang Xue, Zhao Zhang, Zhen Shu, Jinyu Zhu, Nan Mu, Weina Li, Qiang Hao, Zhijun Wang, Li Gong, Wei Zhang, Yingqi Zhang Tags: Rheumatoid Arthritis Source Type: research

First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors Phase I and Clinical Pharmacology
Conclusion Atu027 was safe in patients with advanced solid tumors, with 41% of patients having stable disease for at least 8 weeks. In view of these results, further clinical trials have been initiated, and sFLT1 will be investigated as a potential biomarker.
Source: Journal of Clinical Oncology - December 17, 2014 Category: Cancer & Oncology Authors: Schultheis, Strumberg, Santel, Vank, Gebhardt, Keil, Lange, Giese, Kaufmann, Khan, Drevs Tags: Clinical Trials, Phase I and Clinical Pharmacology, Phase I and Clinical Pharmacology Source Type: research

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients.
CONCLUSIONS: The combination of siG12D-LODER™ and chemotherapy is well tolerated, safe and demonstrated a potential efficacy in patients with LAPC. NCT01188785. PMID: 26009994 [PubMed - as supplied by publisher]
Source: Oncotarget - May 28, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research