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Total 122 results found since Jan 2013.

Suppression of FoxO3a attenuates neurobehavioral deficits after traumatic brain injury through inhibiting neuronal autophagy.
Abstract Traumatic brain injury (TBI) is a serious insult that frequently leads to neurological impairments. Forkhead box O (FoxO) 3a, as transcription factor, has been confirmed to modulate autophagic process. Moreover, FoxO3a is expressed throughout the brain including the hippocampus. However, the role of FoxO3a in the pathophysiology of TBI is unclear. The present study is designed to investigate whether FoxO3a has the neuroprotective effects on rats subjected to TBI, and further to explore the potential molecular mechanisms. Thus, a rat model of TBI was created by using a modified weight-drop device to mimic ...
Source: Behavioural Brain Research - September 6, 2017 Category: Neurology Authors: Sun L, Zhao M, Liu M, Su P, Zhang J, Li Y, Yang X, Wu Z Tags: Behav Brain Res Source Type: research

TNF α affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics.
TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics. Oncotarget. 2017 Sep 01;8(36):60223-60242 Authors: Jensen P, Myhre CL, Lassen PS, Metaxas A, Khan AM, Lambertsen KL, Babcock AA, Finsen B, Larsen MR, Kempf SJ Abstract Neuroinflammation is a hallmark of Alzheimer's disease and TNFα as the main inducer of neuroinflammation has neurodegenerative but also pro-regenerative properties, however, the dose-dependent molecular changes on signaling pathway level are not fully understood. We performed quantitative pro...
Source: Oncotarget - September 29, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Cognitive improvement following ischemia/reperfusion injury induced by voluntary running ‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition.
Cognitive improvement following ischemia/reperfusion injury induced by voluntary running‑wheel exercise is associated with LncMALAT1‑mediated apoptosis inhibition. Int J Mol Med. 2018 Feb 12;: Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Abstract Previous human and animal studies demonstrated that voluntary exercise may improve cognitive function and facilitate neuronal plasticity in ischemia/reperfusion (I/R) models. However, the possible underlying mechanisms remain to be elucidated. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), may be as...
Source: International Journal of Molecular Medicine - February 12, 2018 Category: Molecular Biology Authors: Shang JL, Cheng Q, Duan SJ, Li L, Jia LY Tags: Int J Mol Med Source Type: research

Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway.
Abstract Direct exposure to cadmium (Cd) may induce persistent impairment in learning and memory. However, the outcomes of maternal exposure on the neurological development of offspring are much less clear, and the underlying mechanism leading to toxicity remains undisclosed. Following chronic exposure of female rats during gestation and lactation, low level of Cd was detectable in the cerebral cortex but not in the hippocampus of F1 male offspring. The synapses and neurites in hippocampus were destroyed by high Cd exposure level as evidenced by abnormal morphology and cognitive behavior deficit lasting from child...
Source: Chemosphere - May 10, 2019 Category: Chemistry Authors: Feng J, Chen S, Wang Y, Liu Q, Yang M, Li X, Nie C, Qin J, Chen H, Yuan X, Huang Y, Zhang Q Tags: Chemosphere Source Type: research

Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK ‐3β in 3xTg‐AD mice
AbstractModerate dietary restriction can ameliorate age ‐related chronic diseases such as Alzheimer's disease (AD) by increasing the expression of neurotrophic factors and promoting neurogenesis in the brain. Glycogen synthase kinase‐3β (GSK‐3β) signaling is essential for the coordination of progenitor cell proliferation and differentiation durin g brain development. The mechanisms by which GSK‐3β is involved in dietary restriction induced neurogenesis and cognitive improvement remain unclear. Six‐month‐old male 3xTg‐AD and wild type mice were fed on alternate days (intermittent fasting, IF) or ad libitum ...
Source: Journal of Neurochemistry - June 22, 2020 Category: Neuroscience Authors: Wei Li, Meijian Wu, Yilin Zhang, Xuemin Wei, Jiankun Zang, Yinghua Liu, Yanping Wang, Cheng ‐Xin Gong, Wei Wei Tags: ORIGINAL ARTICLE Source Type: research

Electroacupuncture at Zusanli ameliorates the autistic-like behaviors of rats through activating the Nrf2-mediated antioxidant responses
CONCLUSION: These data suggested that electroacupuncture at ST36 protected nerve function in ASD rats through Nrf2 activation and the antioxidant response.PMID:35339642 | DOI:10.1016/j.gene.2022.146440
Source: Gene - March 27, 2022 Category: Genetics & Stem Cells Authors: Yong-Hong Zhao Hong-Guang Fu Hui Cheng Rui-Juan Zheng Guo Wang Sheng Li En-Yao Li Li-Guo Li Source Type: research

HMGB1-NLRP3-P2X7R pathway participates in PM < sub > 2.5 < /sub > -induced hippocampal neuron impairment by regulating microglia activation
In this study, we focused on the role of HMGB1-NLRP3-P2X7R pathway which mediated the microglia activation in hippocampal neurons impairment induced by PM2.5 using a co-culture model of microglia and hippocampal neurons. We found that PM2.5 resulted in activated microglia and HMGB1-NLRP3 inflammatory pathway, and elevated proinflammatory cytokines of IL-18 and IL-1β in a dose-dependent manner. Notably, we next utilized previously reported pharmacological inhibitors or siRNA for HMGB1 and found that they significantly inhibited the activation of downstream NLRP3 and MAPK pathways derived from PM2.5 exposure, and down-regul...
Source: Ecotoxicology and Environmental Safety - May 23, 2022 Category: Environmental Health Authors: Chong Liu Yingjie She Jia Huang Yongping Liu Wanwei Li Can Zhang Tianliang Zhang Li Yu Source Type: research

High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts
In this study, we visualized and assessed the level of mitophagy in H9c2 cardiomyoblasts at basal conditions and after OXPHOS induction by galactose adaptation. We used cells with a stable expression of a pH-sensitive fluorescent mitochondrial reporter and applied state-of-the-art imaging techniques and image analysis. Our data showed a significant increase in acidic mitochondria after galactose adaptation. Using a machine-learning approach we also demonstrated increased mitochondrial fragmentation by OXPHOS induction. Furthermore, super-resolution microscopy of live cells enabled capturing of mitochondrial fragments withi...
Source: Autophagy - July 5, 2023 Category: Cytology Authors: Gustav Godtliebsen Kenneth Bowitz Larsen Zambarlal Bhujabal Ida S Opstad Mireia Nager Abhinanda R Punnakkal Trine B Kalstad Randi Olsen Trine Lund Dilip K Prasad Krishna Agarwal Truls Myrmel Asa Birna Birgisdottir Source Type: research

Focal Scn1a knockdown induces cognitive impairment without seizures.
Abstract Cognitive impairment is a common comorbidity in pediatric epilepsy that can severely affect quality of life. In many cases, antiepileptic treatments fail to improve cognition. Therefore, a fundamental question is whether underlying brain abnormalities may contribute to cognitive impairment through mechanisms independent of seizures. Here, we examined the possible effects on cognition of Na(v)1.1 down-regulation, a sodium channel principally involved in Dravet syndrome but also implicated in other cognitive disorders, including autism and Alzheimer's disease. Using an siRNA approach to knockdown Na(v)1.1 s...
Source: Neurobiology of Disease - January 11, 2013 Category: Neurology Authors: Bender AC, Natola H, Holmes GL, Scott RC, Lenck-Santini PP Tags: Neurobiol Dis Source Type: research

Trichostatin A epigenetically increases calpastatin expression, and inhibits calpain activity and calcium‐induced SH‐SY5Y neuronal cell toxicity
This study demonstrates that TSA attenuates calcium‐induced neuronal cell death by the inhibition of calpain activity which is mediated in part by increased calpastatin expression via histone hyperacetylation within calpastatin promoter region. Our study provides a novel mechanism for the neuroprotective effect of HDAC inhibitors on AD. This article is protected by copyright. All rights reserved.
Source: FEBS Journal - October 18, 2013 Category: Research Authors: Jungwon Seo, Sangmee Ahn Jo, Soojin Hwang, Catherine Jeonghae Byun, Hyeon‐Ju Lee, Du‐Hyong Cho, Dueon Kim, Young Ho Koh, Inho Jo Tags: Original Article Source Type: research

β-asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice.
Abstract β-asarone is an active component of the Acori graminei rhizome that is a traditional Chinese medicine clinically used in treating dementia in China. However, the cognitive effect of β-asarone and its mechanism has remained elusive. Here, we used asenescence-accelerated prone 8 (SAMP8) mice, which mimic many of the salient features of Alzheimer's disease (AD), to further investigate whether modulation of the ROCK signaling pathway and/or autophagy, synaptic loss is involved in the effects of β-asarone on learning and memory. SAMP8 mice at the age of 6 months were intragastrically administered by β-asar...
Source: Brain Research - January 20, 2014 Category: Neurology Authors: Chen Y, Wei G, Nie H, Lin Y, Tian H, Liu Y, Yu X, Cheng S, Yan R, Wang Q, Hui Liu D, Deng W, Lai Y, Hong Zhou J, Xia Zhang S, Wei Lin W, Feng Chen D Tags: Brain Res Source Type: research

Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: A cholinesterase dependent mechanism.
This study proves that cadmium induces a more pronounced, but not selective, cell death on acetylcholine esterase (AChE) on cholinergic neurons. Moreover, MTT and LDH assays showed a dose dependent decrease of cell viability in NS56 cells. The ACh treatment of SN56 cells did not revert cell viability reduction induced by cadmium, but siRNA transfection against AChE partially reduced it. Our present results provide new understanding of the mechanisms contributing to the harmful effects of cadmium on the function and viability of neurons, and the possible relevance of cadmium in the pathogenesis of neurodegenerative diseases...
Source: Toxicology - September 5, 2014 Category: Toxicology Authors: Pino JD, Zeballos G, Anadon MJ, Capo MA, Díaz MJ, García J, Frejo MT Tags: Toxicology Source Type: research

Characterizing Protein Interactions Employing a Genome-Wide siRNA Cellular Phenotyping Screen
by Apichat Suratanee, Martin H. Schaefer, Matthew J. Betts, Zita Soons, Heiko Mannsperger, Nathalie Harder, Marcus Oswald, Markus Gipp, Ellen Ramminger, Guillermo Marcus, Reinhard Männer, Karl Rohr, Erich W.er, Robert B. Russell, Miguel A. Andrade-Navarro, Roland Eils, Rainer König Characterizing the activating and inhibiting effect of protein-protein interactions (PPI) is fundamental to gain insight into the complex signaling system of a human cell. A plethora of methods has been suggested to infer PPI from data on a large scale, but none of them is able to characterize the effect of this interaction. Here, we present ...
Source: PLoS Computational Biology - September 25, 2014 Category: Biology Authors: Apichat Suratanee et al. Source Type: research