Filtered By:
Education: Learning

This page shows you your search results in order of relevance. This is page number 4.

Order by Relevance | Date

Total 122 results found since Jan 2013.

Abstract 4549: CDK2 inhibition causes anaphase catastrophe through the centrosomal protein CP110
Aneuploidy is frequently detected in human cancers and is implicated in carcinogenesis. Whether aneuploidy is an anti-neoplastic target remains to be learnt. We previously uncovered an unrecognized consequence of Cdk2 inhibition that causes lung cancer cells to undergo anaphase catastrophe, growth inhibition and apoptosis. Cells with activating KRAS mutations were especially sensitive to Cdk2 inhibition. The mechanism of Cdk2-mediated anaphase catastrophe and how activated KRAS promotes this effect was the subject of this study. Live-cell imaging provided direct evidence that after Cdk2 inhibition, lung cancer cells develo...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Hu, S., Danilov, A. V., Godek, K. M., Orr, B., Tafe, L. J., Memoli, V. A., Galimberti, F., Ravi, S., DeCastro, A. J., Lu, Y., Mustachio, L. M., Sekula, D. J., Andrew, A. S., Freemantle, S. J., Compton, D. A., Dmitrovsky, E. Tags: Experimental and Molecular Therapeutics Source Type: research

Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala
Publication date: Available online 26 February 2015 Source:Brain, Behavior, and Immunity Author(s): Stacey L. Kigar , Liza Chang , Anthony P. Auger Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowled...
Source: Brain, Behavior, and Immunity - March 4, 2015 Category: Neurology Source Type: research

Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala.
Abstract Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowledge, no study has been done investigating the involvement of Gadd45b in neurodevelopmental programming of social behavior. To address...
Source: Brain, Behavior, and Immunity - February 26, 2015 Category: Neurology Authors: Kigar SL, Chang L, Auger AP Tags: Brain Behav Immun Source Type: research

Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.
Abstract The activation of α7 nAChRs has been shown to improve hippocampal-dependent learning and memory. However, the molecular mechanism of α7 nAChRs' action remains elusive. We previously reported that activation of α7 nAChRs induced a prolonged enhancement of glutamatergic synaptic transmission in a PKA-dependent manner. Here, we investigated any connection between the activation of the α7 nAChR and cAMP signaling in hippocampal neurons. To address this question, we employed a FRET-based biosensor to measure the intracellular cAMP levels directly via live cell imaging. We found that application of the α7 ...
Source: Neuropharmacology - April 29, 2015 Category: Drugs & Pharmacology Authors: Cheng Q, Yakel JL Tags: Neuropharmacology Source Type: research

Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway
Abstract Bisphenol A (BPA) is an environmental xenoestrogenic endocrine disruptor, utilized for production of consumer products, and exerts adverse effects on the developing nervous system. Recently, we found that BPA impairs the finely tuned dynamic processes of neurogenesis (generation of new neurons) in the hippocampus of the developing rat brain. Curcumin is a natural polyphenolic compound, which provides neuroprotection against various environmental neurotoxicants and in the cellular and animal models of neurodegenerative disorders. Here, we have assessed the neuroprotective efficacy of curcumin against BPA-m...
Source: Molecular Neurobiology - May 12, 2015 Category: Neurology Source Type: research

Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion
Abstract IMM-H004, a 3-piperazinylcoumarin compound derived from coumarin, has been proved effective against CA1 cell loss and spatial learning impairments resulting from transient global ischemia/reperfusion (TGCI/R), while the mechanism is still largely unknown. Here, we confirmed that treatment of rats with IMM-H004 immediately after TGCI/R ameliorated delayed neuronal death (DND) in the CA1 of hippocampus and cortex. Further study suggested that IMM-H004 contributed to the expression of antiapoptotic protein survivin through the activation of PI3K-dependent protein kinase B (PKB/Akt), which led to the phosphor...
Source: Molecular Neurobiology - January 7, 2016 Category: Neurology Source Type: research

Low-Molecular-Weight Fucoidan Attenuates Mitochondrial Dysfunction and Improves Neurological Outcome After Traumatic Brain Injury in Aged Mice: Involvement of Sirt3.
Abstract Traumatic brain injury (TBI) is a leading cause of death and long-term disability. Fucoidan, a sulfated polysaccharide extracted from brown algae, possesses potent anti-oxidative and anti-inflammatory effects. Considering TBI happens frequently in adults, especially in aged individuals, we herein sought to define the protective effects of low-molecular-weight fucoidan (LMWF) in the aged mice. 16- to 18-month-old mice administered with LMWF (1-50 mg/kg) or vehicle were subjected to TBI using a controlled cortical impact (CCI) model. LMWF at the doses of 10 and 50 mg/kg significantly reduced both cortical...
Source: Cellular and Molecular Neurobiology - January 7, 2016 Category: Cytology Authors: Wang T, Zhu M, He ZZ Tags: Cell Mol Neurobiol Source Type: research

BOD1 Is Required for Cognitive Function in Humans and Drosophila
We report that fibroblast cell lines derived from homozygous BOD1 mutation carriers show aberrant localisation of the cell cycle kinase PLK1 and its phosphatase PP2A at mitotic kinetochores. However, in contrast to the mitotic arrest observed in BOD1-siRNA treated HeLa cells, patient-derived cells progressed through mitosis with no apparent segregation defects but at an accelerated rate compared to controls. The relatively normal cell cycle progression observed in cultured cells is in line with the absence of gross structural brain abnormalities in the affected individuals. Moreover, we found that in normal adult brain tis...
Source: PLoS Genetics - May 10, 2016 Category: Genetics & Stem Cells Authors: Sahar Esmaeeli-Nieh Source Type: research

GSE72534 Modeling genome-wide transcriptional cis-regulation in n LNCaP-abl cell line after siRNA knock down of a series of gene factors RNA-seq
We describe, MARGE, Model-based Analysis of the Regulation of Gene Expression, a robust methodology that leverages a large library of genome-wide H3K27ac ChIP-seq profiles to predict key regulated genes and cis-regulatory regions in human or mouse. MARGE adopts a gene centric approach to define a regulatory potential that summarizes the aggregate activity of multiple cis-regulatory elements on each gene. This model is effective in describing cis-regulatory activity and, unlike the super-enhancer based approach, is highly predictive of gene expression changes in response to BET-bromodomain inhibitors. We show that linear co...
Source: GEO: Gene Expression Omnibus - May 16, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Dissociable roles for histone acetyltransferase p300 and PCAF in hippocampus and perirhinal cortex‐mediated object memory
Abstract The importance of histone acetylation for certain types of memory is now well established. However, the specific contributions of the various histone acetyltransferases to distinct memory functions remain to be determined; therefore, we employed selective histone acetyltransferase protein inhibitors and short‐interference RNAs to evaluate the roles of CREB‐binding protein (CBP), E1A‐binding protein (p300) and p300/CBP‐associated factor (PCAF), in hippocampus and perirhinal cortex‐mediated object memory. Rats were tested for short‐ and long‐term memory in the object‐in‐place task, a task which rel...
Source: Genes, Brain and Behavior - May 31, 2016 Category: Genetics & Stem Cells Authors: Krista A. Mitchnick, Samantha D. Creighton, Jacob M. Cloke, Michael Wolter, Oleksiy Zaika, Bethany Christen, Monika Van Tiggelen, Bettina E. Kalisch, Boyer D. Winters Tags: Original Article Source Type: research

Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles METHOD
This study demonstrates the advantage of integrating a large compendium of historical epigenetic data for genomic studies of transcriptional regulation.
Source: Genome Research - July 26, 2016 Category: Genetics & Stem Cells Authors: Wang, S., Zang, C., Xiao, T., Fan, J., Mei, S., Qin, Q., Wu, Q., Li, X. L., Xu, K., He, H. H., Brown, M., Meyer, C. A., Liu, X. S. Tags: METHOD Source Type: research

Novel compound from Polygonum multiflorum inhibits inflammatory response in LPS-stimulated microglia by upregulating AMPK/ Nrf2 pathways
Publication date: Available online 19 August 2016 Source:Neurochemistry International Author(s): Sun Young Park, Mei Ling Jin, Seon Yeong Chae, Min Jung Ko, Yung Hyun Choi, Geuntae Park, Young-Whan Choi Polygonum multiflorum extracts are known to improve memory and learning ability, and have neuroprotective and anti-aging activity. However, its function and the underlying mechanisms in neuroinflammation-mediated neurodegenerative disease remain poorly understood. In the present study, we investigated the anti-neuroinflammatory effects of several compounds from P. multiflorum, and found a novel compound, CRPE55IB. The CRPE...
Source: Neurochemistry International - August 19, 2016 Category: Neuroscience Source Type: research

Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles METHOD
This study demonstrates the advantage of integrating a large compendium of historical epigenetic data for genomic studies of transcriptional regulation.
Source: Genome Research - September 19, 2016 Category: Genetics & Stem Cells Authors: Wang, S., Zang, C., Xiao, T., Fan, J., Mei, S., Qin, Q., Wu, Q., Li, X., Xu, K., He, H. H., Brown, M., Meyer, C. A., Liu, X. S. Tags: METHOD Source Type: research

Dynamic association of epigenetic H3K4me3 and DNA 5hmC marks in the dorsal hippocampus and anterior cingulate cortex following reactivation of a fear memory.
Abstract Epigenetic mechanisms such as DNA methylation and histone methylation are critical regulators of gene transcription changes during memory consolidation. However, it is unknown how these epigenetic modifications coordinate to control gene expression following reactivation of a previously consolidated memory. Here, we found that retrieval of a recent contextual fear conditioned memory increased global levels of H3 lysine 4-trimethylation (H3K4me3) and DNA 5-hydroxymethylation (5hmC) in area CA1 of the dorsal hippocampus. Further experiments revealed increased levels of H3K4me3 and DNA 5hmC within a CpG-enri...
Source: Neurobiology of Learning and Memory - February 19, 2017 Category: Neurology Authors: Webb WM, Sanchez RG, Perez G, Butler AA, Hauser RM, Rich MC, O'Bierne AL, Jarome TJ, Lubin FD Tags: Neurobiol Learn Mem Source Type: research