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Total 217 results found since Jan 2013.

Oxymatrine attenuates oxidized low ‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway
Int J Mol Med. 2021 Oct;48(4):187. doi: 10.3892/ijmm.2021.5020. Epub 2021 Aug 9.ABSTRACTOxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb Sophora flavescens Aiton, has been demonstrated to exert anti‑inflammatory and atherosclerotic effects, but the molecular mechanism has yet to be elucidated. Accumulating evidence indicates an important role of NLR family pyrin domain containing 3 (NLRP3) inflammasome‑mediated pyroptosis in the pathogenesis of atherosclerosis. The present study was undertaken to investigate whether oxymatrine attenuates oxidized low‑density lipoprotein (ox‑LDL)‑ind...
Source: International Journal of Molecular Medicine - August 9, 2021 Category: Molecular Biology Authors: Xin Jin Wan Fu Jiaxiu Zhou Niannian Shuai Yan Yang Bo Wang Source Type: research

Tetramethylpyrazine Preserves the Integrity of Blood-Brain Barrier Associated With Upregulation of MCPIP1 in a Murine Model of Focal Ischemic Stroke
Tetramethylpyrazine (TMP), a prominent ingredient of Chinese herb Ligusticum chuanxiong Hort, is known to suppress neuroinflammation and protect blood-brain barrier (BBB) integrity. We investigated whether monocyte chemotactic protein-induced protein 1 (MCPIP1, also known as Regnase-1), a newly identified zinc-finger protein, plays a role in TMP-mediated anti-inflammation and neuroprotection. Male C57BL/6 mice were subjected to focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) for 2 h, followed by reperfusion for 24 h. TMP (25 mg/kg or 50 mg/kg) or vehicle was administered intraperitoneally 12Â...
Source: Frontiers in Pharmacology - July 28, 2021 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O- β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway Molecules doi: 10.3390/molecules26133852 Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Astragalus membranaceus is a famous herb found among medicinal and food plants in East and Southeastern Asia. The Nrf2-ARE assay-guided separation of an extract from Jing liqueur led to the identification of a nontoxic Nrf2 activator, methylnissolin-3-O-β-D-glucopyranoside (MNG, a component of A. ...
Source: Molecules - June 24, 2021 Category: Chemistry Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Tags: Article Source Type: research

Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury
In conclusion, our study shows that resveratrol can reduce ROS in cardiomyocytes by PI3K/AKT signaling pathway activation, and effectively inhibit the apoptosis of cardiomyocytes, thus having a direct protective effect on cardiomyocytes under SR.PMID:34107386 | DOI:10.1016/j.acthis.2021.151739
Source: Acta Histochemica - June 9, 2021 Category: Biochemistry Authors: Dongmin Yu Jianxian Xiong Yizhou Gao Jinghang Li Dawei Zhu Xiaowei Shen Lifu Sun Xiaowei Wang Source Type: research

Formononetin attenuates H < sub > 2 < /sub > O < sub > 2 < /sub > -induced cell death through decreasing ROS level by PI3K/Akt-Nrf2-activated antioxidant gene expression and suppressing MAPK-regulated apoptosis in neuronal SH-SY5Y cells
In this study, we investigated the protective effect of formononetin on hydrogen peroxide (H2O2)-induced death of human neuroblastoma SH-SY5Y cells and its underlying molecular mechanism. Formononetin suppressed H2O2-induced cytotoxicity. H2O2-induced increase in the intracellular reactive oxygen species (ROS) levels was decreased by formononetin, together with the enhanced expression of the antioxidant genes. H2O2-induced elevation of the Bax/Bcl-2 ratio and cleaved caspase-3 and caspase-7 levels were lowered by formononetin treatment. Moreover, formononetin repressed H2O2-induced phosphorylation of mitogen-activated prot...
Source: Neurotoxicology - June 2, 2021 Category: Neurology Authors: Mayuko Sugimoto Risa Ko Hiromi Goshima Atsushi Koike Makio Shibano Ko Fujimori Source Type: research

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research