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Total 217 results found since Jan 2013.
Leonurine suppresses prostate cancer growth < em > in vitro < /em > and < em > in vivo < /em > by regulating miR-18a-5p/SLC40A1 axis
This study further unveiled the mechanism by which Leo inhibited prostate cancer progression, which provides a promising potential for its future clinical application.PMID:36588358 | DOI:10.4103/0304-4920.365459
Source: The Chinese Journal of Physiology - January 2, 2023 Category: Physiology Authors: Bin Liang Shouxi Cui Songnian Zou Source Type: research
Lonp1 and Sig-1R contribute to the counteraction of ursolic acid against ochratoxin A-induced mitochondrial apoptosis
In conclusion, through mutual promotion between Lonp1 and Sig-1R, UA could effectively relieve OTA-induced apoptosis in vitro and break the vicious cycle between oxidative stress and ERS, which activated the mitochondrial apoptosis pathway.PMID:36587836 | DOI:10.1016/j.fct.2022.113592
Source: Food and Chemical Toxicology - January 1, 2023 Category: Food Science Authors: Qipeng Zhang Wenying Chen Boyang Zhang Yiwen Zhang Yuqing Xiao Yichen An Lingyun Han Huiqiong Deng Song Yao Hongwei Wang Xiao Li Shen Source Type: research
Natural carbazole alkaloid murrayafoline A displays potent anti-neuroinflammatory effect by directly targeting transcription factor Sp1 in LPS-induced microglial cells
Bioorg Chem. 2022 Sep 28;129:106178. doi: 10.1016/j.bioorg.2022.106178. Online ahead of print.ABSTRACTNeuroinflammation is a leading cause for neurological disorders. Carbazole alkaloids, isolated from the medicinal plants of Murraya species (Rutaceae), have exhibited wide pharmacological activities particularly for neuroinflammation. However, its underlying cellular targets and molecular mechanisms still remain unclear. In current study, we found that murrayafoline A (MA), a carbazole alkaloid obtained from Murraya tetramera, potently inhibited the production of neuroinflammation mediators, such as nitric oxide (NO), TNF-...
Source: Bioorganic Chemistry - October 11, 2022 Category: Chemistry Authors: Chao-Hua Li Ying Zhou Peng-Fei Tu Ke-Wu Zeng Yong Jiang Source Type: research
