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Nutrition: Herbs
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Total 217 results found since Jan 2013.
Vitexin attenuates autoimmune hepatitis in mouse induced by syngeneic liver cytosolic proteins via activation of AMPK/AKT/GSK-3 β/Nrf2 pathway
In conclusion, vitexin ameliorated hepatic injury in EAH mice through activation of the AMPK/AKT/GSK-3β pathway and upregulation of the Nrf2 gene.PMID:34953801 | DOI:10.1016/j.ejphar.2021.174720
Source: European Journal of Pharmacology - December 26, 2021 Category: Drugs & Pharmacology Authors: Lei Zhang Dazhi Chen Yulu Tu Tiantian Sang Tongtong Pan Hongwei Lin Chao Cai Xiaozhi Jin Faling Wu Lanman Xu Yongping Chen Source Type: research
Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
CONCLUSION: SDP protected renal tubular epithelial cells from cell pyroptosis and EMT by regulating the albumin-induced mitochondrial dysfunction/ MAVS/ NLRP3-ASC-caspase-1 inflammasome signaling pathway.PMID:34908861 | PMC:PMC8665879 | DOI:10.2147/JIR.S341598
Source: Cell Research - December 15, 2021 Category: Cytology Authors: Yiye Zhu Guoshun Huang Yang Yang Chen Yong Xiang Yu Gang Wang Lan Yi Kun Gao Fang Tian Shushu Qian Enchao Zhou Yanqin Zou Source Type: research
Yi Shen Juan Bi Pill Regulates the Bone Immune Microenvironment via the JAK2/STAT3 Signaling Pathway in Vitro
This study provides a new strategy for regulating the bone immune microenvironment in RA with traditional Chinese medicine.
Source: Frontiers in Pharmacology - December 14, 2021 Category: Drugs & Pharmacology Source Type: research
Brusatol Inhibits Proliferation and Invasion of Glioblastoma by Down-Regulating the Expression of ECM1
Brusatol (Bru), a Chinese herbal extract, has a variety of anti-tumor effects. However, little is known regarding its role and underlying mechanism in glioblastoma cells. Here, we found that Bru could inhibit the proliferation of glioblastoma cells in vivo and in vitro. Besides, it also had an inhibitory effect on human primary glioblastoma cells. RNA-seq analysis indicated that Bru possibly achieved these effects through inhibiting the expression of extracellular matrix protein 1 (ECM1). Down-regulating the expression of ECM1 via transfecting siRNA could weaken the proliferation and invasion of glioblastoma cells and prom...
Source: Frontiers in Pharmacology - December 14, 2021 Category: Drugs & Pharmacology Source Type: research
Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation
Biochem Biophys Res Commun. 2021 Dec 1;587:99-106. doi: 10.1016/j.bbrc.2021.11.101. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apopto...
Source: Biochemical and Biophysical Research communications - December 6, 2021 Category: Biochemistry Authors: Chun-Xiao Wang Li-Hua Chen Hai-Bin Zhuang Ze-Sheng Shi Zhi Chuan Chen Jian-Peng Pan Zhong-Shi Hong Source Type: research
Chinese Herbal Preparation SaiLuoTong Alleviates Brain Ischemia via Nrf2 Antioxidation Pathway –Dependent Cerebral Microvascular Protection
Stroke is one of the most devastating diseases worldwide. The Chinese herbal preparation SaiLuoTong (SLT) capsule showed outstanding therapeutic effects on stroke and its sequelae. The aim of this study was to further elucidate its therapeutic mechanism. We duplicated a permanent cerebral ischemia model in rats by MCAO and used SLT (33 and 16.5 mg/kg) to intervene. The results showed SLT dose dependently decreased infarction volumes, relieved neuron degeneration and loss, and ameliorated neurological functions, and the dose of 33 mg/kg had statistical significance (compared with the model group, p < 0.05); SLT of 33 ...
Source: Frontiers in Pharmacology - November 2, 2021 Category: Drugs & Pharmacology Source Type: research
Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells
Fitoterapia. 2021 Oct 19:105066. doi: 10.1016/j.fitote.2021.105066. Online ahead of print.ABSTRACTLewy bodies are characteristic spherical inclusions in Parkinson's disease (PD) that are formed by α-synuclein fibrils. Ferruginol (Fer) is an amonomeric compound isolated from a traditional Chinese herb. Here, we show that Fer exerted potent neuroprotective effects in both in vitro and in vivo PD models. Neuronal cells transfected with A53T mutant (A53T) α-synuclein plasmids and treated with Fer exhibited attenuated the cytotoxicity induced by pathogenic A53T α-synuclein overexpression. Further, when we transfected neurona...
Source: Fitoterapia - October 22, 2021 Category: Biochemistry Authors: Xiaohong Wang Guiyun Cao Dongyi Ding Fei Li Xuesong Zhao Jiahua Wang Yang Yang Source Type: research
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1 α/BNIP3 to inhibit mitochondrial apoptosis pathway
Biomed Pharmacother. 2021 Aug 9;142:111965. doi: 10.1016/j.biopha.2021.111965. Online ahead of print.ABSTRACTCisplatin (CDDP) may induce apoptosis of renal tubular epithelial cells (RTEC) and cause CDDP-induced acute kidney injury (CAKI) during cancer treatment, but yet lack of preventive measures and effective treatment. As a new Chinese herbal preparation, Panax notoginseng saponins (PNS) has been found to mitigate CDDP-induced CAKI through elevating the expression of HIF-1α in the rat model, according to the data from our previous works. However, the underlying link between HIF-1α and apoptosis has not been well eluci...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 13, 2021 Category: Drugs & Pharmacology Authors: Qingqing Li Yansong Zhang Yufang Yang Songqing Huang Xiaoqin Zou Congying Wei Taolin Liang Xiaobin Zhong Source Type: research
Oxymatrine attenuates oxidized low ‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway
Int J Mol Med. 2021 Oct;48(4):187. doi: 10.3892/ijmm.2021.5020. Epub 2021 Aug 9.ABSTRACTOxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb Sophora flavescens Aiton, has been demonstrated to exert anti‑inflammatory and atherosclerotic effects, but the molecular mechanism has yet to be elucidated. Accumulating evidence indicates an important role of NLR family pyrin domain containing 3 (NLRP3) inflammasome‑mediated pyroptosis in the pathogenesis of atherosclerosis. The present study was undertaken to investigate whether oxymatrine attenuates oxidized low‑density lipoprotein (ox‑LDL)‑ind...
Source: International Journal of Molecular Medicine - August 9, 2021 Category: Molecular Biology Authors: Xin Jin Wan Fu Jiaxiu Zhou Niannian Shuai Yan Yang Bo Wang Source Type: research
