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Nutrition: Soy isoflavones

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Total 46 results found since Jan 2013.

Genistein exerts a cell-protective effect via Nrf2/HO-1/PI3K signaling in A β25-35-induced Alzheimer's disease models in vitro.
CONCLUSIONS: These results suggest that genistein exerts a neuroprotective effect on SH-SY5Y cells in vitro via Nrf2/HO-1/PI3K signaling, providing a foundation for the application of genistein in the treatment of neurodegenerative diseases related to Nrf2/HO-1/PI3K signaling. PMID: 33605427 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - February 21, 2021 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research

The Laminin-Induced Phosphorylation of PKC δ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes.
The Laminin-Induced Phosphorylation of PKCδ Regulates AQP4 Distribution and Water Permeability in Rat Astrocytes. Cell Mol Neurobiol. 2020 Aug 26;: Authors: Noël G, Tham DKL, Guadagno E, MacVicar B, Moukhles H Abstract In astrocytes, the water-permeable channel aquaporin-4 (AQP4) is concentrated at the endfeet that abut the blood vessels of the brain. The asymmetric distribution of this channel is dependent on the function of dystroglycan (DG), a co-expressed laminin receptor, and its associated protein complex. We have demonstrated that the addition of laminin to astrocytes in culture causes the cl...
Source: Cellular and Molecular Neurobiology - August 25, 2020 Category: Cytology Authors: Noël G, Tham DKL, Guadagno E, MacVicar B, Moukhles H Tags: Cell Mol Neurobiol Source Type: research

Characterization of Zika Virus Endocytic Pathways in Human Glioblastoma Cells
Zika virus (ZIKV) infections can cause microcephaly and neurological disorders. However, the early infection events of ZIKV in neural cells remain to be characterized. Here, by using a combination of pharmacological and molecular approaches and the human glioblastoma cell T98G as a model, we first observed that ZIKV infection was inhibited by chloroquine and NH4Cl, indicating a requirement of low intracellular pH. We further showed that dynamin is required as the ZIKV entry was affected by the specific inhibitor dynasore, small interfering RNA (siRNA) knockdown of dynamin, or by expressing the dominant-negative K44A mutant...
Source: Frontiers in Microbiology - March 5, 2020 Category: Microbiology Source Type: research

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis
In conclusion, for the first time, our study suggested that genistein has anticarcinoma effect for PTC patients in the range of 2.5 and 80 μg/ml in thyroid carcinoma cells, which was probably through cytoplasmic translocation of β-catenin. Further study will be needed to determine whether genistein could be used in clinical trial of high-risk PTC.
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Chunyan Zhang, Bin Lv, Cuihua Yi, Xiujie Cui, Shaofeng Sui, Xueen Li, Mei Qi, Chunyan Hao, Bo Han, Zhiyan Liu Tags: Research Paper Source Type: research

Genistein suppresses psoriasis-related inflammation through a STAT3-NF- κB-dependent mechanism in keratinocytes.
In this study, we investigated the effects of genistein on imiquimod (IMQ)-induced psoriasis-like skin lesions in vivo and explored the mechanisms underlying those effects in vitro. It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23. In vitro studies, genistein inhibited the proliferation of human keratinocyte HaCaT cells and inhibited the expression of inf...
Source: International Immunopharmacology - February 8, 2019 Category: Allergy & Immunology Authors: Wang A, Wei J, Lu C, Chen H, Zhong X, Lu Y, Li L, Huang H, Dai Z, Han L Tags: Int Immunopharmacol Source Type: research

Levobupivacaine-induced vasoconstriction involves caldesmon phosphorylation mediated by tyrosine kinase-induced ERK phosphorylation.
Abstract The goals of this study were to examine the cellular signaling pathways associated with the phosphorylation of caldesmon, the phosphorylation-dependent inhibitory protein of myosin phosphatase (CPI-17), and the 20-kDa regulatory light chain of myosin (MLC20) induced by levobupivacaine in isolated rat aortas. The effects of genistein, tyrphostin 23, GF109203X, PD98059, Y-27632, 1-butanol, and ML-7 HCl on levobupivacaine-induced contraction were assessed. The effect of genistein on the simultaneous calcium-tension curves induced by levobupivacaine was examined. The effects of GF109203X, genistein, PD98059 a...
Source: European Journal of Pharmacology - November 1, 2018 Category: Drugs & Pharmacology Authors: Lee SH, Kwon SC, Ok SH, Hong JM, Kim JY, Ahn SH, Il Bae S, Shin Y, Sohn JT Tags: Eur J Pharmacol Source Type: research

Genistein and Myd88 Activate Autophagy in High Glucose-Induced Renal Podocytes In Vitro.
CONCLUSIONS This study demonstrated that Genistein-induced autophagy could be a potential treatment strategy for glomerular diseases. PMID: 29999001 [PubMed - in process]
Source: Medical Science Monitor - July 14, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research

Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression.
Authors: Zhu J, Ren J, Tang L Abstract Colon cancer is characterized by invasion and migration. DNA methylation of CpG islands in tumor suppressor genes is considered to be an epigenetic mechanism underlying cancer development. Epigenetic silencing of a gene may be reversed by drugs, including genistein. The present study aimed to determine the effect of genistein on Wnt inhibitory factor 1 (WIF1) and invasion, and migration of colon cancer cells. The viability of HT29 colon cancer cells was suppressed by genistein in a dose dependent manner. Following 72 h of treatment with 10, 20 and 60 µmol/l genistein, incre...
Source: Molecular Medicine Reports - March 25, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

G protein-coupled estrogen receptor is involved in the anti-inflammatory effects of genistein in microglia
Conclusion Taken together, these data provide the first evidence that genistein exerts anti-inflammatory effects in microglial cells via GPER activation. These beneficial effects of genistein may represent a new strategy for the treatment of neuroinflammatory diseases. Graphical abstract
Source: Phytomedicine - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver
In conclusion, our findings show that CME is the mechanism responsible for the internalization of the canalicular transporters BSEP and MRP2 in E17G-induced cholestasis. The shift of these transporters from raft to non-raft microdomains could be a prerequisite for the transporters to be endocytosed under cholestatic conditions.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - March 1, 2018 Category: Molecular Biology Source Type: research

The α2 isoform Na,K‐ATPase modulates contraction of rat mesenteric small artery via cSrc–dependent Ca2+ sensitization
ConclusionsData suggest that micromolar ouabain potentiates agonist‐induced contraction of rat mesenteric small artery via Na,K‐ATPase dependent cSrc activation, which increases Ca2+ sensitization of vascular smooth muscle cells by MYPT1 phosphorylation. This mechanism may be critical for acute control of vascular tone.
Source: Acta Physiologica - February 26, 2018 Category: Physiology Authors: Elena V. Bouzinova, Lise Hangaard, Christian Staehr, Aleksandra Mazur, Avelino Ferreira, Alexander Chibalin, Shaun L. Sandow, Zijian Xie, Christian Aalkjaer, Vladimir V. Matchkov Tags: Regular Paper Source Type: research

Mechanisms of canalicular transporter endocytosis in the cholestatic rat liver.
In conclusion, our findings show that CME is the mechanism responsible for the internalization of the canalicular transporters BSEP and MRP2 in E17G-induced cholestasis. The shift of these transporters from raft to non-raft microdomains could be a prerequisite for the transporters to be endocytosed under cholestatic conditions. PMID: 29355600 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - January 17, 2018 Category: Biochemistry Authors: Miszczuk GS, Barosso IR, Larocca MC, Marrone J, Marinelli RA, Boaglio AC, Sánchez Pozzi EJ, Roma MG, Crocenzi FA Tags: Biochim Biophys Acta Source Type: research